Abstract
Metabolites isolated from marine invertebrates, callipeltin A 1, crambescidin 2, ptilomycalin A 3, celeromycalin 4, gymnochrome B 5, gymnochrome D 6 and isogymnochrome D 7 previously shown bioactive on either herpes simplex virus 1 (2, 3, 4) or human immunodeficiency virus (1, 5, 6, 7), were tested on a new in vitro bioassay using the dengue virus 1. Only gymnochrome D and isogymnochrome D isolated from the living fossil crinoid Gymnocrinus richeri are highly potent dengue antiviral agents.
Keywords: Key words. Marine natural products; porifera; echinodermata; antiviral; dengue.
Footnotes
Received 22 August 1997; received after revision 6 November 1997; accepted 24 November 1997