Figure 2.

mousiPLIER identified LVs associated with aging. A, Venn diagram showing the number of significant LVs and their overlap across cell types and experimental conditions. B, LV41 is deceased significantly in wild-type microglia during aging. C, A heatmap showing significant LV-associated biological pathways or cell type markers. A linear model is used to test the effect of aging on each LV. p values are adjusted for multiple comparisons using Benjamini–Hochberg method. An LV is differentially expressed if FDR < 0.05. LV, latent variable; AD, Alzheimer's disease; WT, wild-type. D, Top 20 genes with highest weight associated with LV41 and their potential annotation. LV, latent variable.