Artificial intelligence (AI) is emerging in various domains of our life [1]. In the medical domain, great promises are attributed to this technology to empower the field of medical technology and imaging to contribute to a better understanding of diseases in terms of science and improved healthcare. On the other hand, generative AI models, which can synthesize data, images, or text, also raise concerns, especially regarding scientific publishing. In this context, we asked chatGPT Version 3.5 [2] with the prompt “write an editorial on AI in medical physics” to create an editorial in the context of this special issue. The result is given in the following:
“Title: Harnessing the Power of AI in Medical Physics: A Quantum Leap for Healthcare
Introduction
In recent years, the marriage of artificial intelligence (AI) and medical physics has paved the way for revolutionary advancements in healthcare. The convergence of cutting-edge technology and the intricate field of medical physics has not only transformed diagnostics and treatment planning but has also opened new frontiers for personalized and efficient patient care. As we stand on the precipice of a new era in medicine, it is imperative to explore and embrace the multifaceted impact of AI in medical physics.
Precision Medicine and Personalized Treatment
One of the most profound contributions of AI to medical physics lies in its ability to enable precision medicine. By analyzing vast datasets, AI algorithms can identify patterns and correlations that may elude the human eye. In medical physics, this translates to personalized treatment plans tailored to individual patient profiles. Whether it be in radiation therapy or diagnostic imaging, AI algorithms can optimize treatment parameters, minimizing side effects and enhancing therapeutic outcomes.
Enhanced Diagnostics and Imaging
AI has emerged as a powerful ally in the realm of medical imaging, offering unprecedented accuracy and speed in diagnosis. Machine learning algorithms, trained on diverse datasets, can swiftly and accurately detect anomalies in medical images, aiding radiologists in their diagnostic assessments. This not only expedites the diagnostic process but also ensures early detection of diseases, significantly improving patient prognosis.
Automated Treatment Planning
The complexity of treatment planning in medical physics often requires intricate calculations and meticulous attention to detail. AI systems can streamline this process by automating treatment planning tasks, allowing medical physicists to focus on refining and optimizing treatment strategies. This not only increases efficiency but also reduces the likelihood of errors, ensuring a higher standard of patient safety.
Real-time Decision Support
In critical situations, timely decision-making is paramount. AI applications in medical physics provide real-time decision support by continuously analyzing patient data, monitoring treatment progress, and alerting healthcare professionals to deviations from the expected course. This real-time feedback loop enhances the adaptability of treatment plans, enabling healthcare providers to make swift adjustments when necessary.
Challenges and Ethical Considerations
While the integration of AI in medical physics brings about transformative benefits, it also poses challenges and ethical considerations. Ensuring the privacy and security of patient data, addressing algorithmic bias, and maintaining transparency in AI decision-making processes are critical aspects that demand careful attention. Striking a balance between innovation and ethical considerations is imperative for the responsible and sustainable deployment of AI in healthcare.
Conclusion
The synergy between AI and medical physics marks a paradigm shift in the way we approach healthcare. From personalized treatment plans to enhanced diagnostics, the potential for improving patient outcomes is vast. As we navigate this transformative landscape, it is essential for stakeholders in the healthcare ecosystem to collaborate, innovate responsibly, and uphold ethical standards. The future of medical physics lies at the intersection of human expertise and artificial intelligence, offering a beacon of hope for more effective, accessible, and personalized healthcare.”
Although this ChatGPT 3.5 generated text seems to cover a broad range of topics and is quite optimistic about the field, the superficial treatment of complex subjects and lack of specific details illustrate that editorial work can still profit from human expertise.
In this special issue, we compiled a set of articles demonstrating how AI emerges into the broad field of medical physics: Fechter et al. review deep learning approaches for interventional radiotherapy [3]. Besides reporting on current approaches, open-source software and open data are also considered. Wang et al. describe an approach to enhance dose calculations by using a super-resolution approach [4] while the work by Nachbar et al. describes the advantages of AI based contouring of the prostate in MR images for online adaptive radiotherapy [5]. AI approaches also emerge in the field of nuclear medicine. This issue features two approaches applying such methods in PET imaging [6], [7] and one for scintigraphy [8]. Enhancing diagnostic imaging is reported by Führes et al. using a feature-guided deep learning approach to increase contrast to noise in diffusion-weighted imaging in liver lesions [9]. A generative AI approach to derive synthetic CTs from MR scans independently of their contrast is put forward by Simko et al. [10].
Besides these applications, AI has proven valuable in analyzing (medical) images. This issue presents recent decision-making approaches [11], [12] and algorithms for monitoring disease progression [13].
Though AI techniques demonstrated superior results, they also need to demonstrate generalization and when applied in routine clinical use need to undergo quality control. Strittmatter et al. investigated how well multimodal image registration algorithms compare and generalize when applied in minimally invasive image-guided interventions [14]. Mercolli et al. propose a concept on how quality management could be implemented for machine learning systems [15].
In summary, this special issue highlights new work on integrating AI in medical physics, showcasing advancements in diagnostic imaging, treatment planning, and disease monitoring.
However, these emerging AI techniques must also be robust and trustworthy when applied in clinical applications. The example of the AI-generated editorial demonstrates a need for careful design, testing and evaluation of AI methods. Research presented in this special issue touches on this, emphasizing the need for generalization and quality management in clinical applications.
References
- 1.Maslej N., Fattorini L., Brynjolfsson E., et al. Stanford University; Stanford, CA, USA: 2023. The AI Index 2023 Annual Report, AI Index Steering Committee, Institute for Human-Centered AI.https://aiindex.stanford.edu/wp-content/uploads/2023/04/HAI_AI-Index-Report_2023.pdf Accessed 3rd January 2024. [Google Scholar]
- 2.OpenAI. ChatGPT [Large language model]; 2023. Accessed 3rd January 2024 https://chat.openai.com/chat
- 3.Fechter T., Sachpazidis I., Baltas D. The use of deep learning in interventional radiotherapy (brachytherapy): a review with a focus on open source and open data. Z Med Phys. 2022 doi: 10.1016/j.zemedi.2022.10.005. [DOI] [PubMed] [Google Scholar]
- 4.Wang Y., Liu Y., Bai Y., Zhou Q., Xu S., Pang X. A generalization performance study on the boosting radiotherapy dose calculation engine based on super-resolution. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2022.10.006. [DOI] [PubMed] [Google Scholar]
- 5.Nachbar M., Lo Russo M., Gani C., et al. Automatic AI-based contouring of prostate MRI for online adaptive radiotherapy. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.05.001. [DOI] [PubMed] [Google Scholar]
- 6.Leube J., Horn M., Hartrampf P.E., Buck A.K., Lassmann M., Tran-Gia J. PSMA-PET improves deep learning-based automated CT kidney segmentation. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.08.006. [DOI] [PubMed] [Google Scholar]
- 7.Zatcepin A., Kopczak A., Holzgreve A., et al. Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2022.11.008. [DOI] [PubMed] [Google Scholar]
- 8.Hajianfar G., Sabouri M., Salimi Y., et al. Artificial intelligence-based analysis of whole-body bone scintigraphy: the quest for the optimal deep learning algorithm and comparison with human observer performance. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.01.008. [DOI] [PubMed] [Google Scholar]
- 9.Fuhres T., Saake M., Lorenz J., et al. Feature-guided deep learning reduces signal loss and increases lesion CNR in diffusion-weighted imaging of the liver. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.07.005. [DOI] [PubMed] [Google Scholar]
- 10.Simko A., Bylund M., Jonsson G., et al. Towards MR contrast independent synthetic CT generation. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.07.001. [DOI] [PubMed] [Google Scholar]
- 11.Güllmar D., Hsu W.C., Reichenbach J.R. Predicting disease-related MRI patterns of multiple sclerosis through GAN-based image editing. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.12.001. [DOI] [PubMed] [Google Scholar]
- 12.Turk O., Ozhan D., Acar E., Akinci T.C., Yilmaz M. Automatic detection of brain tumors with the aid of ensemble deep learning architectures and class activation map indicators by employing magnetic resonance images. Z Med Phys. 2022 doi: 10.1016/j.zemedi.2022.11.010. [DOI] [PubMed] [Google Scholar]
- 13.Raj A., Tollens F., Caroli A., Norenberg D., Zöllner F.G. Automated prognosis of renal function decline in ADPKD patients using deep learning. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.08.001. [DOI] [PubMed] [Google Scholar]
- 14.Strittmatter A., Schad L.R., Zöllner F.G. Deep learning-based affine medical image registration for multimodal minimal-invasive image-guided interventions – a comparative study on generalizability. Z Med Phys. 2023 doi: 10.1016/j.zemedi.2023.05.003. [DOI] [PubMed] [Google Scholar]
- 15.Mercolli L., Romingera A., Shia K. Towards quality management of artificial intelligence systems for medical applications. Z Med Phys. 2024 doi: 10.1016/j.zemedi.2024.02.001. [DOI] [PubMed] [Google Scholar]
