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. 2005 Aug 19;94(4):328–333. doi: 10.1111/j.1349-7006.2003.tb01441.x

Urinary bladder lesions induced by persistent chronic low‐dose ionizing radiation

Alina Romanenko 1, Keiichirou Morimura 2, Hideki Wanibuchi 2, Min Wei 2, Wadim Zaparin 3, Wladimir Vinnichenko 3, Anna Kinoshita 2, Alexander Vozianov 3, Shoji Fukushima 2,✉
PMCID: PMC11160273  PMID: 12824899

Abstract

The incidence of urinary bladder cancer in the Ukraine increased from 26.2 to 43.3 per 100 000 population between 1986 and 2001 after the Chernobyl accident. The present study was conducted to evaluate the development of radiation‐dependent lesions in the urinary bladders of people living in cesium 137 (137Cs) radio‐contaminated areas of the Ukraine. Bladder urothelial biopsies from 159 male and 5 female patients were subjected to histological examination and immunohistochemical study of p38 mitogen‐acti‐vated protein kinase (MAPK), as well as the p50 and p65 subunits of nuclear factor kappa B (NF‐kB). A pattern of chronic proliferative atypical cystitis accompanied with large areas of sclerosis of connective tissue in the lamina propria was commonly observed in all cases. Interestingly, these lesions were associated with a dramatic increase in the incidences of dysplasia/carcinoma in situ, and, moreover, small urothelial carcinomas were incidentally detected. We defined the overall condition as “Chernobyl cystitis.'’Greatly elevated levels of p38, p65 and p50 expression in the urothelium were evident and the patients showed increased 137Cs in urine. The data support conclusions from our previous studies of a critical role for increased oxidative stress in generation of urinary bladder urothelial lesions in individuals chronically exposed to low‐dose 137Cs radiation. Alterations in the p38 MARK cascade and accumulation of NF‐kB subunits could be crucial early molecular events in the pathogenesis of Chernobyl cystitis. (Cancer Sci 2003; 94: 328–333)

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