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[Preprint]. 2024 Jun 1:2024.05.27.596028. [Version 1] doi: 10.1101/2024.05.27.596028

Figure 5: MS-peptide association score plotted by pQTL rank.

Figure 5:

Scatterplot of the MSPA scores against the rank of the affinity proteomics pQTLs of the deCODE SOMAscan (panel A, data in Table S7) and the UKB-PPP OLINK (panel B, data in Table S8) studies, ranked starting with the lowest p-value. The first 100 pQTLs (out of 322 pQTLs for SOMAscan and 374 pQTLs for Olink) are coloured to indicate likely protein expression QTLs (MSPA score > 0.8; green) and likely epitope effect driven pQTLs (MSPA score < 0.2; red), the sigmoid curve indicates the assumed dependence of power to detect a pQTL as a function of the strength of the association, approximated by the rank of the pQTL in the respective study; MSPA scores limited to 46 pQTLs that were reported on the same variant in deCODE (panel C) and UKBPPP (panel D); scatterplot of the effect size (beta) of the 46 pQTLs reported deCODE and UKBPPP (panel E, data in Table S9).