Fig. 1 |. The impact of the intestinal microbiome on exercise performance in genetically and metagenomically diverse mice.

a, DO mice were profiled for genome, microbiome, metabolome and energy metabolism and assessed for exercise performance. b,c, Diversity of performance parameters on a treadmill (b) and running wheels (c). d,e, Algorithm-predicted versus measured treadmill distance based on a model including all assessed non-genetic features (d) and only features from 16S rDNA sequencing (e). f, Schematic of interventions to test for microbiome causality in DO mice. g,h, Wheel (g) and treadmill (h) running of DO mice treated with antibiotics (Abx). i, Correlation of treadmill running by donors and recipients of microbiome transfers from DO mice to germ-free mice. Error bars indicate means ± s.e.m. **, P < 0.01; ***, P < 0.001. Exact n and P values are presented in Supplementary Table 2.