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. Author manuscript; available in PMC: 2024 Jun 10.
Published in final edited form as: Biomaterials. 2016 Dec 2;118:84–93. doi: 10.1016/j.biomaterials.2016.12.001

Figure 1.

Figure 1.

Stabilized NPs were developed for aerosol delivery to orthotopic lung tumors. Functional polyesters were prepared by the polycondensation of trimethylolpropane allyl ether (TPAE) and suberoyl chloride (diACl-C8) in dichloromethane (DCM) using pyridine as promotor, followed by the thiol-ene reaction with different ratios of 20 amino thiols and 3 alkyl thiols functional thiols (Scheme S1). High throughput in vitro screening of the functional polyester library enabled the discovery of efficacious polymeric carriers for siLuc delivery to A549-Luc cancer cells. Stabilized PE4K-A13-0.33C6 and PE4K-A13-0.33C10 NPs were able to silence gene expression in A549-Luc xenograft and orthotopic tumors by administration of intravenous injection or aerosol inhalation, respectively.