Table 8.

Cytotoxicity activity of various parts of O. europaea: summary of research findings.

Parts Used	Extracts	Cell Line	In Vitro Model	Key Results	Reference
Seed	Methanolic	Human colorectal cell (HCT-116) Human melanoma cells (501 Mel) Colon cancer cell line (HT29) Prostate cancer cell line (PC3) Breast cancer cell line (MCF-7) Malignant mesothelioma cell line (REN) Hepatocellular cancer cell line (HEPG-2) Human promyelocytic leukemia cells (HL-60) Human glioblastoma cell line (T98G) Human lung cancer cell lines (A549) Pancreatic cancer cell line (AsPC-1) Larynx cancer cell line (HEP2) Luminal A breast cancer Cell line (MCF7) Human chronic leukemia cell line (K562)	MTT and MTS assay Cell cycle in-cell ELISA Kit Cell death detection ELISA+ The RNeasy mini kit Resazurin assay Agarose gel electrophoresis Assessment of cell growth inhibition WST assay for cell viability	IC50 = 875.5 µg/mL	[210]
Fruit	Methanolic			IC50 = 154.3 µg/mL
	Vegetable oil			IC50 = 81.9 ± 6.9 mM IC50 = 19.1 ± 5.8 mM	[202]
	Ethanolic			IC50 = 1000 µg/mL IC50 = 600 µg/mL	[83]
Leave	Aqueous			IC50 = 203.1 µg/mL IC50 = 236.6 µg/mL	[205]
				IC50 = 15.5 ± 0.40 µg/mL IC50 = 10.2 ± 0.45 µg/mL IC50 = 9.9 ± 0.15 µg/mL IC50 = 10.4 ± 0.16 µg/mL IC50 = 8.6 ± 0.13 µg/mL	[211]
				IC50 = 100 µg/mL	[212]
				IC50 = 21.91 ± 1.8 μg/mL	[213]
	Ethanolic			IC50 = 200 µg/mL	[214]
				IC50 = 100 µM IC50 = 40.8 μM IC50 = 52 µM	[215]
	Methanolic			IC50 = 21.5 mg GAE/L	[209]
				EC50 = 0.26 mg/mL	[20]