DRP-1 plays a Central Role in Stimulating Both Mitochondrial Biogenesis and Mitophagy. (a) Representative immunoblots of MFN-1. (b) Representative immunoblots of MFN-2. (c) Densitometry analysis of MFN-1; no significance was observed. (d) Densitometry analysis of MFN-2; no significance was observed. (e,f) Representative immunoblots of DRP-1 and PINK-1. (g) Densitometry analysis of DRP-1; * p < 0.05, Ln + Sed vs. Ln + Ex and HFS + Sed vs. HFS + Ex; ** p < 0.01, Ln + Sed vs. HFS + Ex. (h) Densitometry of PINK-1; * p < 0.05, Ln + Sed vs. HFS + Ex and HFS + Sed vs. HFS + Ex. Data shown as means ± SEM, n = 3 per group.