Figure 3.

The LIGPLOT diagram of the protein–peptide interaction between the RBD and SPIKENET. The pink SPIKENET peptide residues are shown on the top, and the yellow amino acid residues of the RBD from SARS-CoV-2—two are shown at the bottom. The SPIKENET peptide consists of 15 amino acid residues, 14 of which are shown in non-bonded interactions with the RBD of SARS-CoV-2, proving that SPIKENET has a significant binding affinity with the spike glycoprotein-1. These findings strongly suggest that SPIKENET is a potent competitive inhibitor of S1 [13].