Figure 12.

SPIKENET (SPK) diminishes MHV-1-induced pathological changes in the brain, lungs, heart, liver, kidney, and skin during long-term infection. Representative histological images of hematoxylin and eosin (H&E) stained brain, lung, heart, liver, kidney, and skin tissue sections of a standard mouse (A,D,G,J,M,P) and an infected mouse at 12 months (B,E,H,K,N,Q). MHV-1-inoculated mice treated with 5 mg/kg SPIKENET (SPK) eased all of these changes (C,F,I,L,O,R) (H&E original magnification is 400× for (A–O) and 66× for (P–R)) [8,13,21].