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[Preprint]. 2024 Jun 17:2024.06.15.599113. [Version 1] doi: 10.1101/2024.06.15.599113

Figure 1. Overview of the MPAC workflow.

Figure 1.

MPAC calculates inferred pathway levels (IPLs) from real and permuted CNA and RNA data. It filters real IPLs using the permuted IPLs to remove spurious IPLs. Then, MPAC focuses on the largest pathway subset network with filtered IPLs to compute Gene Ontology (GO) term enrichment, predict patient groups, and identify key group-specific proteins.