Figure 3. The two pseudo-twofold interfaces mediating filament formation of the autoinhibited LRRK2I2020T on microtubules.
(A) Two LRRK2 copies involved in the WD40:WD40 pseudo-twofold interface are highlighted in color with the rest of the map dimmed. The axis is indicated by a black ellipsoid. (B) Side view of the LRRK2 WD40:WD40 dimer from the composite map and its cartoon representation. The view direction is shown as eye symbols in (A). WD40:WD40 interaction surface is highlighted in the cartoon representation. (C) Similar with (A), showing the COR:COR LRRK2 dimer and axis. The same single copy of LRRK2 is highlighted in black contours for reference. (D) similar with (B), showing the side view and cartoon representation of LRRK2 COR:COR dimer from the composite map.