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[Preprint]. 2024 Jun 16:2024.06.15.24308845. [Version 1] doi: 10.1101/2024.06.15.24308845

Figure 4: Correlation of NLRP3 inflammasome activation with altered mitophagy and muscle weakness.

Figure 4:

Pearson correlation plot demonstrating correlation coefficient values for the NLRP3 RNA level, p-S65-Ub level, manual muscle testing (MMT) score and disease duration, by sex.

Both sexes: NLRP3 and p-S65-Ub, p = 0.059; NLRP3 and MMT score, p = 0.072; NLRP3 and disease duration, p = 0.543; p-S65-Ub and MMT score, p = 0.58; p-S65-Ub and disease duration, p = 0.699.

Males: NLRP3 and p-S65-Ub, p = 0.116; NLRP3 and MMT score, p = 0.032; NLRP3 and disease duration, p = 0.699; p-S65-Ub and MMT score, p = 0.359; p-S65-Ub and disease duration, p = 0.49.

Females: NLRP3 and p-S65-Ub, p = 0.106; NLRP3 and MMT score, p = 0.706; NLRP3 and disease duration, p-=0.781); p-S65-Ub and MMT score, p = 0.642; p-S65-Ub and disease duration, p = 0.898.