Figure 4.

A) Chromosome diagrams depict the inversion between 5p14.2 and 5q14.3 in DGAP218. Above, TADs containing the breakpoints are shown, with the breakpoint positions indicated by vertical yellow bars. Protein-coding genes are shown in blue and non-coding genes in green, with a single isoform depicted per gene. TAD borders were defined in (Dixon et al. 2012). Triangular contact maps display micro-C data from (Krietenstein et al. 2020). B) Expanded view of the genomic region surrounding the 5p14.2 breakpoints in DGAP218. C) Expanded view of the genomic region surrounding the 5q14.3 breakpoints in DGAP218. The directly disrupted lncRNA MEF2C-AS1 is highlighted in red.