Figure 2.

LymphGen classification on the Memorial Sloan Kettering cohort. (A) 396 diffuse large B-cell lymphoma cases sequenced by IMPACT were classified by LymphGen into 6 subclasses: MCD, EZB, BN2, N1, ST2, A53. Cases with more than one assigned subclass are indicated as “Composite”. Cases that cannot be classified into these subclasses are labeled as “Other”. (B) Correlation of LymphGen classification and cell-of-origin (COO) by Han’s algorithm. (C) Categories of the subclassification: tumors with subtype probabilities of >90% or 50-90% were defined as ‘‘Core’’ or ‘‘Extended’’ subtype members, respectively. (D) Composition of the subtypes in the cases from the “Core” group (classified based on probability >90%). (E) Correlation of LymphGen classification and COO by Han’s algorithm in the cases from the “Core” group.