Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 8;109(7):2144–2156. doi: 10.3324/haematol.2023.284305

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2024 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PMC Copyright notice

Figure 4. — Ppm1b regulates hematopoietic stem cell pool and B-cell differentiation in stressed hematopoiesis. (A) Experimental design for HN252-treated mice in response to 5-FU-induced emergency hematopoiesis. Long blue arrow indicates HN252 or Vehicle injection every 2 days. Black arrow indicates the time point for 5-FU injection. Red arrows indicates the bleeding for blood assays. (B) Quantification of white blood cells (WBC) and lymphocytes in peripheral blood at indicated time points during HN252 injection (N=6). (C) The mice were treated with HN252 as in (A), and the ratio of B cells in peripheral blood was analyzed by flow cytometry (N=6). (D and E) The number of B cells (D) and the percentage of Lin^-Sca-1⁺c-Kit⁺ (LSK) cells (E) from indicated mice in (C) were measured by flow cytometry (N=6). Data are presented as mean ± Standard Deviation. All P values were determined by unpaired two-tailed Student t test. See also Online Supplementary Figure S4. BM: bone marrow; GO: gene ontology; PBMC: peripheral blood mononuclear cells.