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. 2024 Jun 6;38(7):1477–1487. doi: 10.1038/s41375-024-02287-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A 5-year event-free survival (%), B 5-year overall survival (%), C 5-year cumulative incidence of relapse (%), D 5-year cumulative incidence of death in remission (%). EFS event-free survival, OS overall survival, CIR clinical incidence of relapse, DCR death in complete remission, CCLSG Children’s Cancer and Leukemia Study Group, CoALL Childhood Acute Lymphoblastic Leukemia, NOPHO Nordic Society of Pediatric Hematology and Oncology, UKALL United Kingdom Acute Lymphoblastic Leukemia; AIEOP-BFM, Associazione Italiana di Ematologia e Oncologia Pediatrica and Berlin Frankfurt Münster; ALL IC-BFM Acute Lymphoblastic Leukemia Intercontinental-Berlin Frankfurt Münster, DCOG Dutch Childhood Oncology Group, JACLS Japan Childhood Leukemia Study Group.