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. 2024 Jun 5;27(7):110188. doi: 10.1016/j.isci.2024.110188

Figure 7.

Figure 7

LAMC2 activates the PI3K/Akt signaling pathway to influence the expression of VEGFA

(A) Expression of VEGFA, AKT, and p-AKT in knockdown LAMC2 KYSE30 cells.

(B) The expression of the LAMC2 in knockdown LAMC2 KYSE30 cells (n = 3 per group).

(C) The expression of the VEGFA in knockdown LAMC2 KYSE30 cells cultured in hypoxia (n = 3 per group).

(D) CCK-8 assay showed that the cell viability of knockdown LAMC2 KYSE30 cells cultured in hypoxia (n = 3 per group).

(E) Colony formation assay of KYSE30 cells with knockdown of LAMC2 in hypoxia (n = 3 per group).

(F) Transwell assay show the migratory and invasive abilities of KYSE30 cells with knockdown of LAMC2 in hypoxia. The scale bar shows 100 μm (n = 5 per group). Statistical significance was analyzed by Student’s t-test. Data are mean ± SEM. ∗p < 0.05, ∗∗p < 0.01., ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, ns indicates no significance.