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Journal of Virology logoLink to Journal of Virology
. 2000 Dec;74(24):12003.

Replication of Herpes Simplex Virus Type 1 within Trigeminal Ganglia Is Required for High Frequency but Not High Viral Genome Copy Number Latency

Richard L Thompson 1, N M Sawtell 1
PMCID: PMC112490

Volume 74, no. 2, p. 965–974, 2000. Page 971, column 2, 2nd full paragraph, lines 8–11: The sentence beginning “In mouse TG,” should read “In mouse TG, Coen et al. (4) observed reduced numbers of LAT+ neurons in mice latently infected with a TK mutant and Jacobson et al. (21a) showed that this reduction was due to a TK mutation that does not affect the UL24 gene or its expression. In addition, quantitative PCR analysis of the viral genome has revealed a significant decrease in the amount of latent DNA present in the TG of mice latently infected with TK-null mutants (22, 25, 26).”

Page 973, column 1, last paragraph of the text. Line 8: “(1, 44)” should read “(1, 14a, 44).”

The following should be added to the References:

14a.  Garber, D. A., P. A. Schaffer, and D. M. Knipe. 1997. A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1. J. Virol. 71:5885–5893.

 21a.  Jacobson, J. G., K. L. Ruffner, M. Kosz-Vnenchak, C. B. Hwang, K. K. Wobbe, D. M. Knipe, and D. M. Coen. 1993. Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia. J. Virol. 67:6903–6908.


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