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A, B, Forest plots showing treatment-emergent adverse effects leading to discontinuation (A) and bronchospasm events (B). The weight of each study is the percentage of its contribution to the overall effect estimate. Weights of individual studies might not add up to the subtotal or overall weights because of rounding. Risk of bias is represented as low (+), unclear (?), or high (–). Includes safety population. df = degrees of freedom; IV = inverse variance; M-H = Mantel-Haenszel.
