In the article “Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury,” by Lei Huang, Prativa Sherchan, Yuechun Wang, Cesar Reis, Richard L. Applegate II, Jiping Tang, and John H. Zhang, which appeared on pages 10390–10401 in the July 22, 2015 issue, the representative Western blot band of CD3 in Figure 6A was taken from the wrong source during final figure assembly. The corrected Figure 6 appears below, which includes the correct representative CD3 band while retaining all other elements unchanged. This error does not affect the conclusions of the paper, and the authors sincerely apologize for the oversight.
Figure 6.
Effect of AS252424 and human recombinant active-PI3Kγ protein on neuroinflammation associated with SBI 24 h after surgery. Representative images are shown of Western blot assay for mast cell tryptase, CD3, MPO, E-selectin, and IL-1β levels within peri-resection brain tissues (A). Compared with the vehicle-treated SBI, AS 252424 significantly reduced levels of mast cell tryptase (B), T-cell–associated CD 3 level (C), neutrophil-associated MPO level (D), cell-adhesion molecule E-selectin (E), and IL-1β cytokine (F) elevation by SBI. Human recombinant active-PI3Kγ partially reversed the protective effect of AS252424 against neuroinflammation (n = 6/group). One-way ANOVA followed by Student’s–Newman–Keuls post hoc tests were used. B, **p < 0.001 versus sham; &&p < 0.001 versus SBI + AS252424 10 mg/kg; #p = 0.016 versus SBI + vehicle. C, **p < 0.001 versus sham; &&p = 0.003 versus SBI + AS252424 10 mg/kg; &p = 0.019 versus SBI + AS252424 10 mg/kg. D, *p = 0.023 versus sham; **p < 0.001 versus sham; &&p = 0.004 versus SBI + AS252424 10 mg/kg. E, *p = 0.039 versus sham; **p = 0.002 versus sham; &&p = 0.008 versus SBI + AS252424 10 mg/kg. F, *p = 0.029 versus sham; **p < 0.001 versus sham; &p = 0.026 versus SBI + AS252424 10 mg/kg; &&p = 0.001 versus SBI + AS252424 10 mg/kg.