Using non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, during pregnancy increases the risk of miscarriage. In a prospective cohort study of 1055 pregnant women in the Kaiser Permanente population of northern California, Li and colleagues (p 368) found that the use of NSAIDs or aspirin around the time of conception or during pregnancy increased the risk of miscarriage by 80%. Using acetaminophen (paracetamol) did not increase the risk of miscarriage.
Figure 1.
Credit: TRENO/PHOTONICA