Abstract
This study examines trends in medical use, nonmedical use, diversion sources, and perceived procurement difficulty of prescription medications for nonmedical use among US adolescents.
Prescription stimulants, opioids, and benzodiazepines are 3 of the most commonly prescribed and nonmedically used controlled substances among US adolescents.1,2 Trends in prescribing have occurred and adolescent overdose deaths have increased, partially due to proliferation of counterfeit pills.2,3,4,5,6 This study examined trends in medical use, nonmedical use (NMU), diversion sources, and perceived procurement difficulty of prescription medications for NMU among US adolescents.
Methods
Monitoring the Future is an annual self-administered survey conducted with nationally representative samples of high school students. This study used data collected in 2009 through 2022 from 12th-grade students2; mean response rate was 80.20%. The University of Michigan’s institutional review board approved this study. Parents could opt their child out of the study (eAppendix in Supplement 1), and informed consent was written.
For prescription stimulants, opioids, and benzodiazepines, respondents were asked about lifetime medical use (any vs none), past-year NMU (use without a prescription or other than prescribed, categorized as any vs none), past-year diversion sources (where medications were obtained for NMU; 10 options, including bought on the internet, obtained or bought from a friend or relative, and used from one’s own prescription), and perceived difficulty of obtaining prescription medications for NMU (probably impossible vs other) (eAppendix in Supplement 1).
Descriptive statistics estimated prevalence rates and 95% CIs. Multivariable binary logistic regression models estimated linear trends for medical use, NMU, diversion sources, and perceived difficulty of obtaining prescription medications, overall and by each prescription medication class. Models controlled for sex, race and ethnicity, parental education, urbanicity, and US region. Weighted analyses reported adjusted odds ratios (aORs) and 95% CIs for the linear trends. Missing data were handled using listwise deletion. Linear trends were considered statistically significant if the CIs did not contain 1. Analyses were conducted in Stata 18.0 (StataCorp).
Results
Of the 29 220 adolescents included, 51.84% were female. Between 2009 and 2022, reported lifetime medical use significantly decreased (23.66% to 16.00%; linear trend, aOR = 0.93 [95% CI, 0.91-0.95]), as did past-year NMU (11.49% to 2.38%; linear trend, aOR = 0.82 [95% CI, 0.80-0.85]) (Table 1). Trends in 2 diversion sources significantly declined. In 2009-2010, 57.96% reported being given prescription medications by a friend, which decreased to 26.87% in 2021-2022 (linear trend, aOR = 0.87 [95% CI, 0.81-0.93]); and 44.35% reported buying medications from a friend in 2009-2010, decreasing to 19.42% in 2021-2022 (linear trend, aOR = 0.91 [95% CI, 0.85-0.98]). Among adolescents reporting past-year NMU, the most prevalent diversion source in 2021-2022 was one’s own prescription (37.37%). The prevalence of adolescents reporting multiple diversion sources decreased from 56.27% in 2009-2010 to 29.33% in 2021-2022 (linear trend, aOR = 0.88 [95% CI, 0.82-0.94]). Prevalence of adolescents who reported it would be probably impossible for them to obtain prescription medications for NMU increased from 35.56% in 2009-2010 to 48.96% in 2021-2022 (linear trend, aOR = 1.08 [95% CI, 1.06-1.10]).
Table 1. Trends in Medical Use, Nonmedical Use, Diversion Sources, and Perceived Procurement Difficulty of Prescription Medications Among US Adolescents, 2009-2022a.
| Measures | No. (%) [95% CI] | Linear trend, aOR (95% CI)b | ||||||
|---|---|---|---|---|---|---|---|---|
| 2009-2010 | 2011-2012 | 2013-2014 | 2015-2016 | 2017-2018 | 2019-2020 | 2021-2022 | ||
| Lifetime medical use | n = 4631 | n = 4604 | n = 4140 | n = 4100 | n = 4392 | n = 2768 | n = 2776 | n = 24 099 |
| No. (%) [95% CI] | 1073 (23.66) [22.24-25.14] | 1141 (25.82) [24.35-27.35] | 1001 (24.55) [23.06-26.10] | 910 (23.31) [21.80-24.89] | 858 (19.03) [17.70-20.43] | 583 (20.53) [18.78-22.40] | 442 (16.00) [14.27-17.89] | 0.93 (0.91-0.95) |
| Past-year nonmedical use | n = 4609 | n = 4578 | n = 4104 | n = 4079 | n = 4365 | n = 2749 | n = 2767 | n = 24 018 |
| No. (%) [95% CI] | 523 (11.49) [10.45-12.63] | 535 (12.12) [11.03-13.30] | 454 (11.04) [9.98-12.20] | 385 (9.36) [8.36-10.47] | 344 (7.62) [6.77-8.56] | 163 (5.75) [4.75-6.93] | 72 (2.38) [1.82-3.11] | 0.82 (0.80-0.85) |
| Diversion sources | n = 475 | n = 477 | n = 397 | n = 340 | n = 290 | n = 141 | n = 75 | n = 1822 |
| Bought on internet | 21 (4.19) [2.55-6.82] | 23 (5.85) [3.64-9.29] | 15 (4.25) [2.29-7.73] | 11 (4.14) [1.98-8.45] | 18 (6.89) [4.12-11.31] | 12 (10.29) [5.09-19.68] | 4 (6.47) [2.21-17.48] | 1.02 (0.86-1.21) |
| Took from friend | 36 (6.67) [4.60-9.57] | 26 (4.20) [2.78-6.32] | 20 (4.11) [2.55-6.55] | 19 (6.40) [3.91-10.32] | 8 (2.54) [1.24-5.14] | 10 (7.42) [3.87-13.75] | 8 (8.48) [3.95-17.26] | 0.99 (0.84-1.16) |
| Took from relative | 82 (16.69) [13.12-21.00] | 85 (17.00) [13.48-21.22] | 63 (16.69) [12.77-21.52] | 45 (14.66) [10.67-19.81] | 33 (10.22) [7.12-14.46] | 19 (15.21) [8.95-24.66] | 7 (8.81) [3.65-19.79] | 0.92 (0.83-1.02) |
| Given by friend | 277 (57.96) [52.66-63.08] | 247 (54.61) [49.32-59.81] | 200 (51.06) [45.43-56.67] | 161 (45.69) [39.58-51.93] | 125 (41.75) [35.36-48.43] | 62 (42.34) [32.53-52.80] | 23 (26.87) [17.36-39.12] | 0.87 (0.81-0.93) |
| Given by relative | 75 (14.81) [11.60-18.72] | 97 (21.25) [17.16-26.01] | 66 (16.69) [12.99-21.18] | 50 (14.39) [10.66-19.14] | 47 (16.47) [12.23-21.81] | 31 (23.29) [15.34-33.72] | 15 (13.63) [7.84-22.63] | 1.00 (0.92-1.10) |
| Bought from friend | 203 (44.35) [39.13-49.69] | 174 (36.25) [31.36-41.45] | 140 (33.15) [28.23-38.48] | 116 (35.21) [29.48-41.41] | 105 (38.21) [31.88-44.97] | 49 (31.11) [22.77-40.88] | 15 (19.42) [11.10-31.74] | 0.91 (0.85-0.98) |
| Bought from relative | 12 (2.82) [1.49-5.30] | 23 (5.64) [3.48-9.00] | 12 (2.71) [1.45-5.01] | 15 (4.50) [2.54-7.84] | 10 (3.56) [1.84-6.79] | 8 (7.27) [2.86-17.27] | 3 (2.90) [0.91-8.84] | 0.92 (0.77-1.09) |
| From a prescription I had | 140 (28.99) [24.44-34.02] | 149 (31.53) [26.79-36.69] | 102 (25.39) [20.86-30.52] | 98 (29.46) [24.08-35.49] | 62 (21.74) [16.71-27.79] | 50 (30.36) [22.09-40.12] | 32 (37.37) [25.65-50.79] | 1.01 (0.94-1.08) |
| Bought from drug dealer or stranger | 102 (22.25) [18.06-27.08] | 90 (18.74) [14.88-23.32] | 63 (17.94) [13.88-22.87] | 52 (16.72) [12.49-22.02] | 54 (18.47) [13.99-23.97] | 34 (21.65) [14.52-31.01] | 7 (9.03) [3.95-19.30] | 0.94 (0.86-1.02) |
| Other | 68 (14.79) [11.41-18.97] | 59 (11.87) [8.89-15.68] | 51 (12.38) [9.29-16.31] | 39 (11.80) [8.19-16.71] | 42 (16.16) [11.68-21.92] | 39 (26.57) [18.63-36.37] | 8 (11.53) [4.71-25.60] | 0.99 (0.89-1.10) |
| No. of diversion sources | n = 475 | n = 477 | n = 397 | n = 340 | n = 290 | n = 141 | n = 66 | n = 1822 |
| Multiple | 260 (56.27) [50.99-61.40] | 242 (51.48) [46.17-56.75] | 176 (44.23) [38.74-49.87] | 141 (41.26) [35.30-47.48] | 122 (42.65) [36.23-49.33] | 76 (52.27) [41.85-62.51] | 23 (29.33) [18.92-42.47] | 0.88 (0.82-0.94) |
| Perceived difficulty of obtainingc | n = 4726 | n = 4690 | n = 4208 | n = 4181 | n = 4428 | n = 2806 | n = 2008 | n = 24 249 |
| Probably impossible | 1734 (35.56) [33.97-37.19] | 1770 (38.24) [36.60-39.92] | 1728 (41.57) [39.84-43.31] | 1791 (42.98) [41.24-44.74] | 1965 (45.34) [43.59-47.12] | 1215 (43.41) [41.14-45.71] | 1007 (48.96) [46.15-51.77] | 1.08 (1.06-1.10) |
Abbreviation: aOR, adjusted odds ratio.
The estimates assessing past-year nonmedical prescription drug use, lifetime medical prescription medication use, and sources for nonmedical use came from Form 1 of the Monitoring the Future (MTF) survey (2009-2022; n = 29 220); estimates assessing difficulty to get prescription drugs came from Form 2 of the MTF (2009-2022; n = 29 243). Analyses were weighted.
The adjusted logistic regression models controlled for sex, race and ethnicity, highest level of parental education, metropolitan status of residence, and US region of residence. Of the 29 220 adolescents included, 22.93% were American Indian, Asian, or multiracial, or had missing data; 10.94% were Black; 15.79% were Hispanic; and 50.34% were White. Race and ethnicity were self-reported according to a question provided in the survey instrument.
Response categories for perceived difficulty of obtaining prescription medications were collapsed to compare “probably impossible” with “very easy,” “fairly easy,” “fairly difficult,” and “very difficult.”
Prevalence of adolescents reporting multiple diversion sources significantly decreased for opioids (47.83% to 36.71%; linear trend, aOR = 0.90 [95% CI, 0.82-1.00]) and benzodiazepines (53.09% to 24.30%; linear trend, aOR = 0.86 [95% CI, 0.76-0.98]), but not stimulants (Table 2). Perceived difficulty of obtaining prescription medications for NMU significantly increased for each prescription medication class.
Table 2. Trends in Number of Diversion Sources and Perceived Difficulty in Obtaining Prescription Medications Among US Adolescents, 2009-2022a.
| Measures | No. (%) [95% CI] | Linear trend, aOR (95% CI)b | ||||||
|---|---|---|---|---|---|---|---|---|
| 2009-2010 | 2011-2012 | 2013-2014 | 2015-2016 | 2017-2018 | 2019-2020 | 2021-2022 | ||
| Stimulants | ||||||||
| No. of diversion sources | n = 234 | n = 270 | n = 230 | n = 192 | n = 179 | n = 70 | n = 39 | n = 1001 |
| Multiple sources | 107 (46.48) [38.92-54.21] | 110 (38.22) [31.73-45.16] | 92 (39.06) [32.27-46.30] | 69 (35.42) [27.95-43.68] | 58 (32.41) [25.03-40.79] | 42 (59.05) [46.11-70.85] | 13 (26.07) [14.41-42.49] | 0.94 (0.85-1.03) |
| Perceived difficulty of obtainingc | n = 4688 | n = 4661 | n = 4185 | n = 4155 | n = 4401 | n = 2791 | n = 1999 | n = 24 118 |
| Probably impossible | 918 (19.30) [18.00-20.68] | 928 (20.86) [19.46-22.33] | 939 (22.57) [21.11-24.09] | 993 (23.84) [22.37-25.38] | 1083 (26.34) [24.77-27.97] | 660 (24.77) [22.80-26.85] | 633 (31.65) [29.08-34.34] | 1.08 (1.06-1.11) |
| Opioids | ||||||||
| No. of diversion sources | n = 294 | n = 265 | n = 207 | n = 163 | n = 106 | n = 52 | n = 22 | n = 948 |
| Multiple sources | 143 (47.83) [41.28-54.46] | 119 (48.04) [41.05-55.10] | 79 (38.68) [31.48-46.40] | 67 (45.94) [37.13-55.00] | 36 (35.56) [26.18-46.20] | 20 (36.39) [23.57-51.48] | 8 (36.71) [17.73-60.94] | 0.90 (0.82-1.00) |
| Perceived difficulty of obtainingc | n = 4700 | n = 4664 | n = 4177 | n = 4152 | n = 4399 | n = 2791 | n = 2000 | n = 24 133 |
| Probably impossible | 1020 (21.37) [20.01-22.80] | 922 (20.24) [18.88-21.68] | 944 (22.72) [21.25-24.26] | 1070 (25.97) [24.45-27.55] | 1204 (28.78) [27.17-30.45] | 788 (28.96) [26.90-31.11] | 870 (41.84) [39.10-44.63] | 1.15 (1.12-1.17) |
| Benzodiazepines | ||||||||
| No. of diversion sources | n = 192 | n = 177 | n = 136 | n = 130 | n = 113 | n = 68 | n = 20 | n = 671 |
| Multiple sources | 99 (53.09) [44.72 61.29] | 71 (40.25) [32.04-49.06] | 47 (31.62) [23.79-40.65] | 29 (23.52) [15.87-33.39] | 34 (30.37) [21.64-40.80] | 38 (53.42) [37.76-68.44] | 7 (24.30) [10.75-46.12] | 0.86 (0.76-0.98) |
| Perceived difficulty of obtainingc | n = 4668 | n = 4643 | n = 4166 | n = 4137 | n = 4374 | n = 2186 | n = 2000 | n = 23 461 |
| Probably impossible | 1501 (31.22) [29.68-32.80] | 1586 (34.74) [33.11-36.40] | 1552 (38.00) [36.30-39.74] | 1595 (38.96) [37.24-40.71] | 1721 (40.22) [38.48-41.98] | 897 (40.95) [38.50-43.45] | 739 (37.00) [34.31-39.76] | 1.06 (1.04-1.07) |
Abbreviation: aOR, adjusted odds ratio.
The estimates assessing sources for nonmedical use came from Form 1 of the Monitoring the Future (MTF) survey (2009-2022; n = 29 220); estimates assessing difficulty to get prescription drugs came from Form 2 of the MTF (2009-2022; n = 29 243). Analyses were weighted.
The adjusted logistic regression models controlled for sex, race and ethnicity, highest level of parental education, metropolitan status of residence, and US region of residence. Of the 29 220 adolescents included, 22.93% were American Indian, Asian, or multiracial, or had missing data; 10.94% were Black; 15.79% were Hispanic; and 50.34% were White. Race and ethnicity were self-reported according to a question provided in the survey instrument.
Response categories for perceived difficulty of obtaining prescription medications were collapsed to compare “probably impossible” with “very easy,” “fairly easy,” “fairly difficult,” and “very difficult.”
Discussion
Between 2009 and 2022, US adolescents reported declines in medical use and NMU of prescription medications, concurring with other research.2,3,4,5 This study expands these findings by showing declines in peer-to-peer and multiple sources of diversion and increased perceived difficulty of obtaining prescription medications for NMU. These changes may be partially attributed to prescribing guideline changes5 and COVID-related school closures, which limited social interaction with peers. Study limitations include the cross-sectional design, potential self-report bias, and missing subpopulations of adolescents with lower (eg, homeschooled) and higher (eg, truant) rates of NMU.2 Data from 2020 should be interpreted cautiously due to COVID-related disruptions. Efforts to further reduce NMU and diversion are needed, particularly given the role of counterfeit pills in the adolescent overdose crisis.6 Furthermore, monitoring, storage, and disposal of prescription medications and education regarding them are important.
Section Editors: Kristin Walter, MD, and Jody W. Zylke, MD, Deputy Editors; Karen Lasser, MD, MPH, Senior Editor.
eAppendix. Methods
Data Sharing Statement
References
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Associated Data
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Supplementary Materials
eAppendix. Methods
Data Sharing Statement
