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. 2024 Jul 10;14(7):829. doi: 10.3390/biom14070829

Figure 6.

Figure 6

DS influenced the expression of RIPK3 in luminal breast cancer cells, and this effect was mediated via NFκB and small Rho GTP-ases at least in the T-47D cells. The level of RIPK3 mRNA was quantified using RT-qPCR in the cultures of BT-474 (A) and T-47D (B), which were treated with the tested variants of DS (PM–DS from porcine intestinal mucosa, NF–DS from normal human fascia and DF–DS from fibrosis-affected human fascia) at a concentration of 25 µg/mL and/or the indicated concentration of cardamonin (Car), EHop 016 or rhosin (Rho) for 3 h. Control values were normalized to the endogenous human gene for Tata Binding Protein. The results show relative RIPK3 mRNA expression and are presented as the mean ± SD of four independent experiments. */**—statistically significant differences (p < 0.05/p < 0.01, respectively) versus the control. ^—statistically significant differences (p < 0.001) versus an appropriate DS variant.