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. 2024 Jul 9;12(7):1525. doi: 10.3390/biomedicines12071525

Figure 1.

Figure 1

The domain structure of RIPK1 comprises a kinase domain (KD), an intermediate domain (ID), and a death domain (DD). Within the intermediate domain lies the RIP homotypic interaction motif domain (RHIM), which participates in polymerization and interacts with the RHIM domains of RIPK3, ZBP1, and TRIF. The death domain of RIPK1 facilitates homo-dimerization and interacts with the death domains of TNFR1, TRADD, and FADD. Abbreviations: RIPK1, receptor-interacting protein kinase 1; RIPK3, receptor-interacting protein kinase 3; ZBP1, Z-DNA-binding protein 1, also known as DAI (DNA-dependent activator of interferon regulatory factors) and DLM-1; TRIF, TIR-domain-containing adapter-inducing interferon β; TNFR1, tumor necrosis factor receptor 1; TRADD, TNFR1-associated death domain protein; FADD, Fas-associated death domain.