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SARS-CoV-2 Mpro binding site with viral polyproteins. Mpro splits the viral polyproteins (pp1a and pp1ab) at 11 sites. The cleavage involves a characteristic motif: Leu-Gln (Ser, Ala, Gly). Variability exists in the amino acid sequence at these cleavage sites, with glutamine consistently found at P1 and a preference for leucine at P2. Hydrophilic and hydrophobic residues can be inserted at the P3 position.
