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. 1994 Jan;51(1):19–22. doi: 10.1136/oem.51.1.19

Cancer of the respiratory tract in nickel sinter plant workers: effect of removal from sinter plant exposure.

D C Muir 1, N Jadon 1, J A Julian 1, R S Roberts 1
PMCID: PMC1127895  PMID: 8124457

Abstract

The risk of death due to cancer of the nose or lung was studied in nickel sinter plant workers during the period after they left the sintering operations. It was found that the excess risk of death from both diseases continued for many years after leaving the sinter plant. No effect of age at first exposure could be found. Possible explanations for the continued risk include an irreversible cellular change or the persistence of carcinogenic nickel compounds in the mucosa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMITAGE P., DOLL R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer. 1954 Mar;8(1):1–12. doi: 10.1038/bjc.1954.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adalis D., Gardner D. E., Miller F. J. Cytotoxic effects of nickel on ciliated epithelium. Am Rev Respir Dis. 1978 Aug;118(2):347–354. doi: 10.1164/arrd.1978.118.2.347. [DOI] [PubMed] [Google Scholar]
  3. Bell C. M., Coleman D. A. Predicted mortality patterns in cohort study populations exposed to different types of hazard: can SMRs show a dose-response? Stat Med. 1983 Jul-Sep;2(3):363–371. doi: 10.1002/sim.4780020308. [DOI] [PubMed] [Google Scholar]
  4. DOLL R. Cancer of the lung and nose in nickel workers. Br J Ind Med. 1958 Oct;15(4):217–223. doi: 10.1136/oem.15.4.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kaldor J., Peto J., Easton D., Doll R., Hermon C., Morgan L. Models for respiratory cancer in nickel refinery workers. J Natl Cancer Inst. 1986 Oct;77(4):841–848. [PubMed] [Google Scholar]
  6. Roberts R. S., Julian J. A., Muir D. C., Shannon H. S. A study of mortality in workers engaged in the mining, smelting, and refining of nickel. II: Mortality from cancer of the respiratory tract and kidney. Toxicol Ind Health. 1989 Dec;5(6):975–993. doi: 10.1177/074823378900500606. [DOI] [PubMed] [Google Scholar]
  7. Roberts R. S., Julian J. A., Sweezey D., Muir D. C., Shannon H. S., Mastromatteo E. A study of mortality in workers engaged in the mining, smelting, and refining of nickel. I: Methodology and mortality by major cause groups. Toxicol Ind Health. 1989 Dec;5(6):957–974. doi: 10.1177/074823378900500605. [DOI] [PubMed] [Google Scholar]
  8. Torjussen W., Andersen I. Nickel concentrations in nasal mucosa, plasma, and urine in active and retired nickel workers. Ann Clin Lab Sci. 1979 Jul-Aug;9(4):289–298. [PubMed] [Google Scholar]

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