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. 1994 Mar;51(3):173–180. doi: 10.1136/oem.51.3.173

Prediction of the comparative intensity of pneumoconiotic changes caused by chronic inhalation exposure to dusts of different cytotoxicity by means of a mathematical model.

B A Katsnelson 1, L K Konyscheva 1, Sharapova NYe 1, L I Privalova 1
PMCID: PMC1127935  PMID: 8130845

Abstract

A multicompartmental mathematical model has been used to simulate variations in the cytotoxicity of dusts in the kinetics of the retention, in the pulmonary region and tracheobronchial lymph nodes, of practically insoluble quartzite and titanium dioxide dust particles deposited on the free surfaces of the acini from alveolar air. Experiments with these dusts were conducted on rats exposed to virtually the same dust concentrations in the air for an experimental period of 20 weeks and a period of 10 weeks after exposure. Satisfactory approximation to the experimental data on the retention of these dusts is obtained by using the model parameters that depend either on damage to lung macrophages by phagocytosed particles or on the response of the host organism to this damage by enhanced recruitment of neutrophilic leucocytes; all the other variables of the model being unchanged. The values of the "action integral" computed from this model and multiplied by the index of comparative cytotoxicity of particles in vitro satisfactorily approximate to quantitative differences in the intensity of pneumoconioses caused by the dusts under study by the end of the experimental period. On the whole, the results of the mathematical model agree with the hypothesis that the cytotoxicity of particles plays a key part in both the process of retention of dust in the lung parenchyma and lung associated lymph nodes, and the pathological process caused by the retained dust. Thus given the factors and conditions on which the deposition of practically insoluble dusts in the pulmonary region depends, it is necessary to take into account the multiplicative nature of these two effects of cytotoxicity when predicting the comparative risk of pneumoconiosis.

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Selected References

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  1. Bolton R. E., Vincent J. H., Jones A. D., Addison J., Beckett S. T. An overload hypothesis for pulmonary clearance of UICC amosite fibres inhaled by rats. Br J Ind Med. 1983 Aug;40(3):264–272. doi: 10.1136/oem.40.3.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Kantsel'son B. A., Privalova L. I., Baidosov V. A. Ob "integrale deistviia" kak kriterii sravnitel'noi otsenki i upravleniia khronicheskimi ékspozitsionnymi rezhimami dlia veshchestv s vyrazhennoi material'noi kumuliatsiei. Gig Sanit. 1986 Dec;(12):12–15. [PubMed] [Google Scholar]
  3. Katsnelson B. A., Konysheva L. K., Privalova L. I., Morosova K. I. Development of a multicompartmental model of the kinetics of quartz dust in the pulmonary region of the lung during chronic inhalation exposure of rats. Br J Ind Med. 1992 Mar;49(3):172–181. doi: 10.1136/oem.49.3.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Katsnelson B. A., Privalova L. I. Recruitment of phagocytizing cells into the respiratory tract as a response to the cytotoxic action of deposited particles. Environ Health Perspect. 1984 Apr;55:313–325. doi: 10.1289/ehp.8455313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Privalova L. I., Katsnelson B. A., Yelnichnykh L. N. Some peculiarities of the pulmonary phagocytotic response: dust retention kinetics and silicosis development during long term exposure of rats to high quartz dust levels. Br J Ind Med. 1987 Apr;44(4):228–235. doi: 10.1136/oem.44.4.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Smith T. J. Development and application of a model for estimating alveolar and interstitial dust levels. Ann Occup Hyg. 1985;29(4):495–516. doi: 10.1093/annhyg/29.4.495. [DOI] [PubMed] [Google Scholar]
  7. Vincent J. H., Donaldson K. A dosimetric approach for relating the biological response of the lung to the accumulation of inhaled mineral dust. Br J Ind Med. 1990 May;47(5):302–307. doi: 10.1136/oem.47.5.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Vincent J. H., Johnston A. M., Jones A. D., Bolton R. E., Addison J. Kinetics of deposition and clearance of inhaled mineral dusts during chronic exposure. Br J Ind Med. 1985 Oct;42(10):707–715. doi: 10.1136/oem.42.10.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Vincent J. H., Jones A. D., Johnston A. M., McMillan C., Bolton R. E., Cowie H. Accumulation of inhaled mineral dust in the lung and associated lymph nodes: implications for exposure and dose in occupational lung disease. Ann Occup Hyg. 1987;31(3):375–393. doi: 10.1093/annhyg/31.3.375. [DOI] [PubMed] [Google Scholar]

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