Abstract
Four cases of mesothelioma in a cohort of 999 Finnish anthophyllite miners and millers are described. Three deaths were due to pleural mesothelioma and one to peritoneal mesothelioma among the total of 503 male deaths up to 1991. All four patients with mesothelioma had had long term (13 to 31 years) exposure in anthophyllite mining and milling. The latency time from the onset of employment until diagnosis was 39 to 58 years. All four patients were smokers or ex-smokers and had asbestosis. In three of the cases the pulmonary fibre concentration and fibre type were analysed by transmission electron microscopy. High concentrations (270 to 1100 million fibres/g dry tissue) of anthophyllite fibres were detected. The anthophyllite fibres were thicker and had lower aspect ratios than the values reported for crocidolite fibres retained in the lungs of patients with mesothelioma.
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Selected References
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- Kleinfeld M., Messite J., Kooyman O., Zaki M. H. Mortality among talc miners and millers in New York State. Arch Environ Health. 1967 May;14(5):663–667. doi: 10.1080/00039896.1967.10664815. [DOI] [PubMed] [Google Scholar]
- Meurman L. O., Kiviluoto R., Hakama M. Combined effect of asbestos exposure and tobacco smoking on Finnish anthophyllite miners and millers. Ann N Y Acad Sci. 1979;330:491–495. doi: 10.1111/j.1749-6632.1979.tb18750.x. [DOI] [PubMed] [Google Scholar]
- Meurman L. O., Kiviluoto R., Hakama M. Mortality and morbidity among the working population of anthophyllite asbestos miners in Finland. Br J Ind Med. 1974 Apr;31(2):105–112. doi: 10.1136/oem.31.2.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roggli V. L., Pratt P. C., Brody A. R. Asbestos content of lung tissue in asbestos associated diseases: a study of 110 cases. Br J Ind Med. 1986 Jan;43(1):18–28. doi: 10.1136/oem.43.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stanton M. F., Layard M., Tegeris A., Miller E., May M., Morgan E., Smith A. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst. 1981 Nov;67(5):965–975. [PubMed] [Google Scholar]
- Timbrell V. Deposition and retention of fibres in the human lung. Ann Occup Hyg. 1982;26(1-4):347–369. [PubMed] [Google Scholar]
- Tuomi T. Fibrous minerals in the lungs of mesothelioma patients: comparison between data on SEM, TEM, and personal interview information. Am J Ind Med. 1992;21(2):155–162. doi: 10.1002/ajim.4700210205. [DOI] [PubMed] [Google Scholar]
- Tuomi T., Huuskonen M. S., Virtamo M., Tossavainen A., Tammilehto L., Mattson K., Lahdensuo A., Mattila J., Karhunen P., Liippo K. Relative risk of mesothelioma associated with different levels of exposure to asbestos. Scand J Work Environ Health. 1991 Dec;17(6):404–408. doi: 10.5271/sjweh.1686. [DOI] [PubMed] [Google Scholar]
- WAGNER J. C., SLEGGS C. A., MARCHAND P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Br J Ind Med. 1960 Oct;17:260–271. doi: 10.1136/oem.17.4.260. [DOI] [PMC free article] [PubMed] [Google Scholar]