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. 1994 Apr;51(4):244–249. doi: 10.1136/oem.51.4.244

Pleural mesothelioma and exposure to asbestos: evaluation from work histories and analysis of asbestos bodies in bronchoalveolar lavage fluid or lung tissue in 131 patients.

J C Pairon 1, E Orlowski 1, Y Iwatsubo 1, M A Billon-Galland 1, G Dufour 1, S Chamming's 1, C Archambault 1, J Bignon 1, P Brochard 1
PMCID: PMC1127955  PMID: 8199666

Abstract

Exposure to asbestos was evaluated in 131 patients with pleural malignant mesothelioma in the Paris area between 1986 and 1992 using data from a detailed specific questionnaire and light microscopy analysis of the retention of asbestos bodies in bronchoalveolar lavage fluid or lung tissue. Probable or definite exposure to significant levels of asbestos dust was identified in only 48 (36.6%) subjects, and significant asbestos body counts (above 1 asbestos body/ml in bronchoalveolar lavage fluid or 1000 asbestos bodies/g of dry lung tissue) were found in only 45 (34.3%) subjects. Overall 50 subjects had experienced exposure to only low levels of asbestos or no exposure at all and showed no significant retention of asbestos bodies in the biological sample analysed. Previous studies have shown that light microscopy may be useful in the identification of subjects with previous exposure to asbestos. In this study, apart from cases with obvious exposure to asbestos, a large group of subjects seemed to have a history of exposure or lung retention of asbestos bodies suggestive of very low levels of cumulative exposure, similar to those described in the general population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bignon J., Sebastien P., Di Menza L., Payan H. French mesothelioma register. Ann N Y Acad Sci. 1979;330:455–466. doi: 10.1111/j.1749-6632.1979.tb18747.x. [DOI] [PubMed] [Google Scholar]
  2. Churg A. M., Warnock M. L. Analysis of the cores of ferruginous (asbestos) bodies from the general population. III. Patients with environmental exposure. Lab Invest. 1979 May;40(5):622–626. [PubMed] [Google Scholar]
  3. Churg A., Warnock M. L. Analysis of the cores of ferruginous (asbestos) bodies from the general population. I. Patients with and without lung cancer. Lab Invest. 1977 Sep;37(3):280–286. [PubMed] [Google Scholar]
  4. De Vuyst P., Dumortier P., Moulin E., Yourassowsky N., Yernault J. C. Diagnostic value of asbestos bodies in bronchoalveolar lavage fluid. Am Rev Respir Dis. 1987 Nov;136(5):1219–1224. doi: 10.1164/ajrccm/136.5.1219. [DOI] [PubMed] [Google Scholar]
  5. Dodson R. F., Williams M. G., Jr, O'Sullivan M. F., Corn C. J., Greenberg S. D., Hurst G. A. A comparison of the ferruginous body and uncoated fiber content in the lungs of former asbestos workers. Am Rev Respir Dis. 1985 Jul;132(1):143–147. doi: 10.1164/arrd.1985.132.1.143. [DOI] [PubMed] [Google Scholar]
  6. Friedrichs K. H., Brockmann M., Fischer M., Wick G. Electron microscopy analysis of mineral fibers in human lung tissue. Am J Ind Med. 1992;22(1):49–58. doi: 10.1002/ajim.4700220105. [DOI] [PubMed] [Google Scholar]
  7. Gibbs A. R. Role of asbestos and other fibres in the development of diffuse malignant mesothelioma. Thorax. 1990 Sep;45(9):649–654. doi: 10.1136/thx.45.9.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hirsch A., Brochard P., De Cremoux H., Erkan L., Sebastien P., Di Menza L., Bignon J. Features of asbestos-exposed and unexposed mesothelioma. Am J Ind Med. 1982;3(4):413–422. doi: 10.1002/ajim.4700030407. [DOI] [PubMed] [Google Scholar]
  9. Jones J. S., Pooley F. D., Clark N. J., Owen W. G., Roberts G. H., Smith P. G., Wagner J. C., Berry G., Pollock D. J. The pathology and mineral content of lungs in cases of mesothelioma in the United Kingdom in 1976. IARC Sci Publ. 1980;(30):187–199. [PubMed] [Google Scholar]
  10. Kishimoto T. Cancer due to asbestos exposure. Chest. 1992 Jan;101(1):58–63. doi: 10.1378/chest.101.1.58. [DOI] [PubMed] [Google Scholar]
  11. McDonald J. C., Armstrong B., Case B., Doell D., McCaughey W. T., McDonald A. D., Sébastien P. Mesothelioma and asbestos fiber type. Evidence from lung tissue analyses. Cancer. 1989 Apr 15;63(8):1544–1547. doi: 10.1002/1097-0142(19890415)63:8<1544::aid-cncr2820630815>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  12. Murai Y., Kitagawa M. Asbestos fiber analysis in 27 malignant mesothelioma cases. Am J Ind Med. 1992;22(2):193–207. doi: 10.1002/ajim.4700220206. [DOI] [PubMed] [Google Scholar]
  13. Rogers A. J., Leigh J., Berry G., Ferguson D. A., Mulder H. B., Ackad M. Relationship between lung asbestos fiber type and concentration and relative risk of mesothelioma. A case-control study. Cancer. 1991 Apr 1;67(7):1912–1920. doi: 10.1002/1097-0142(19910401)67:7<1912::aid-cncr2820670716>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  14. Roggli V. L., McGavran M. H., Subach J., Sybers H. D., Greenberg S. D. Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma: a study of 25 cases. Cancer. 1982 Dec 1;50(11):2423–2432. doi: 10.1002/1097-0142(19821201)50:11<2423::aid-cncr2820501130>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  15. Roggli V. L., Pratt P. C., Brody A. R. Asbestos content of lung tissue in asbestos associated diseases: a study of 110 cases. Br J Ind Med. 1986 Jan;43(1):18–28. doi: 10.1136/oem.43.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Roggli V. L., Pratt P. C., Brody A. R. Asbestos fiber type in malignant mesothelioma: an analytical scanning electron microscopic study of 94 cases. Am J Ind Med. 1993 Apr;23(4):605–614. doi: 10.1002/ajim.4700230408. [DOI] [PubMed] [Google Scholar]
  17. Roggli V. L. Quantitative and analytical studies in the diagnosis of mesothelioma. Semin Diagn Pathol. 1992 May;9(2):162–168. [PubMed] [Google Scholar]
  18. Schwartz D. A., Galvin J. R., Burmeister L. F., Merchant R. K., Dayton C. S., Merchant J. A., Hunninghake G. W. The clinical utility and reliability of asbestos bodies in bronchoalveolar fluid. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):684–688. doi: 10.1164/ajrccm/144.3_Pt_1.684. [DOI] [PubMed] [Google Scholar]
  19. Sebastien P., Armstrong B., Monchaux G., Bignon J. Asbestos bodies in bronchoalveolar lavage fluid and in lung parenchyma. Am Rev Respir Dis. 1988 Jan;137(1):75–78. doi: 10.1164/ajrccm/137.1.75. [DOI] [PubMed] [Google Scholar]
  20. Siemiatycki J., Dewar R., Lakhani R., Nadon L., Richardson L., Gérin M. Cancer risks associated with 10 inorganic dusts: results from a case-control study in Montreal. Am J Ind Med. 1989;16(5):547–567. doi: 10.1002/ajim.4700160508. [DOI] [PubMed] [Google Scholar]
  21. Tammilehto L., Tuomi T., Tiainen M., Rautonen J., Knuutila S., Pyrhönen S., Mattson K. Malignant mesothelioma: clinical characteristics, asbestos mineralogy and chromosomal abnormalities of 41 patients. Eur J Cancer. 1992;28A(8-9):1373–1379. doi: 10.1016/0959-8049(92)90523-5. [DOI] [PubMed] [Google Scholar]
  22. Tuomi T., Oksa P., Anttila S., Taikina-aho O., Taskinen E., Karjalainen A., Tukiainen P. Fibres and asbestos bodies in bronchoalveolar lavage fluids of asbestos sprayers. Br J Ind Med. 1992 Jul;49(7):480–485. doi: 10.1136/oem.49.7.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Valleron A. J., Bignon J., Hughes J. M., Hesterberg T. W., Schneider T., Burdett G. J., Brochard P., Hémon D. Low dose exposure to natural and man made fibres and the risk of cancer: towards a collaborative European epidemiology. Report of a workshop held in Paris , 10-12 June, 1991. Br J Ind Med. 1992 Sep;49(9):606–614. doi: 10.1136/oem.49.9.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Warnock M. L. Lung asbestos burden in shipyard and construction workers with mesothelioma: comparison with burdens in subjects with asbestosis or lung cancer. Environ Res. 1989 Oct;50(1):68–85. doi: 10.1016/s0013-9351(89)80049-0. [DOI] [PubMed] [Google Scholar]
  25. Warnock M. L., Wolery G. Asbestos bodies or fibers and the diagnosis of asbestosis. Environ Res. 1987 Oct;44(1):29–44. doi: 10.1016/s0013-9351(87)80084-1. [DOI] [PubMed] [Google Scholar]

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