Abstract
A historical cohort study was carried out in an agricultural research institute in the Republic of Ireland to investigate a perceived excess of cancer deaths among employees. The objectives of the study were (a) to confirm whether or not total or cause specific death rates among selected employees were higher than expected based on national figures, and to quantify any excess, and (b) to identify centres and employee grades associated with any excess risk. The cohort comprised all administrative, research, and technical staff employed for at least two years between 1960 and 1980, giving a final total for analysis of 1323 employees. Employment history was categorised by place of work and employment grade. Deaths among the cohort were identified and causes of deaths verified. Overall the cohort had a lower than expected mortality compared with national rates (O/E = 0.67). Female deaths were too few for analysis but, among the male employees, there was an excess of all cancers (O/E = 1.24; 95% confidence interval (95% CI) 0.8-1.9), in particular brain cancer (O/E = 4.69; 95% CI 1.2-11.4) and bladder cancer (O/E = 9.31, 95% CI 1.9-27.2). The pattern of brain tumour deaths was consistent with an occupational aetiology but it was not possible to identify specific exposures associated with the excess. All four cases occurred among research workers in the plant and soil science area. The pattern of bladder cancers was difficult to interpret. The authors are at present participating in a multicentre study to further investigate cancer risk in laboratory workers.
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- Belli S., Comba P., De Santis M., Grignoli M., Sasco A. J. Cancer mortality patterns among laboratory workers. Lancet. 1990 Jun 30;335(8705):1597–1598. doi: 10.1016/0140-6736(90)91432-a. [DOI] [PubMed] [Google Scholar]
- Cordier S. Risk of cancer among laboratory workers. Lancet. 1990 May 5;335(8697):1097–1097. doi: 10.1016/0140-6736(90)92670-d. [DOI] [PubMed] [Google Scholar]
- Hochberg F., Toniolo P., Cole P. Head trauma and seizures as risk factors of glioblastoma. Neurology. 1984 Nov;34(11):1511–1514. doi: 10.1212/wnl.34.11.1511. [DOI] [PubMed] [Google Scholar]
- Lin R. S., Dischinger P. C., Conde J., Farrell K. P. Occupational exposure to electromagnetic fields and the occurrence of brain tumors. An analysis of possible associations. J Occup Med. 1985 Jun;27(6):413–419. [PubMed] [Google Scholar]
- Mancuso T. F., Ciocco A., el-Attar A. A. An epidemiological approach to the rubber industry. A study based on departmental experience. J Occup Med. 1968 May;10(5):213–232. [PubMed] [Google Scholar]
- Modan B., Baidatz D., Mart H., Steinitz R., Levin S. G. Radiation-induced head and neck tumours. Lancet. 1974 Feb 23;1(7852):277–279. doi: 10.1016/s0140-6736(74)92592-6. [DOI] [PubMed] [Google Scholar]
- Morantz R. A., Neuberger J. S., Baker L. H., Beringer G. B., Kaufman A. B., Chin T. D. Epidemiological findings in a brain-tumor cluster in western Missouri. J Neurosurg. 1985 Jun;62(6):856–860. doi: 10.3171/jns.1985.62.6.0856. [DOI] [PubMed] [Google Scholar]
- Savitz D. A., Moure R. Cancer risk among oil refinery workers. A review of epidemiologic studies. J Occup Med. 1984 Sep;26(9):662–670. [PubMed] [Google Scholar]
- Schuman L. M., Choi N. W., Gullen W. H. Relationship of central nervous system neoplasms to Toxoplasma gondii infection. Am J Public Health Nations Health. 1967 May;57(5):848–856. doi: 10.2105/ajph.57.5.848. [DOI] [PMC free article] [PubMed] [Google Scholar]