Abstract
Phenol (87.3 mg/l), p-cresol (58.6 mg/l), o-cresol (76.9 mg/l), and 2,5-xylenol (36.7 mg/l) were detected in the urine of workers employed in the distillation of the high temperature phenolic fraction of tar (carbolic oil). The concentrations of these compounds in the urine of non-exposed male workers was 11.7 mg/l, 25.7 mg/l, 68.1 micrograms/l, and 69 micrograms/l respectively. The excretion rates were 4.20 mg/h for phenol, 2.4 mg/h for p-cresol, 3.3 mg/h for o-cresol; and 1.5 mg/h for 2,5-xylenol. The highest concentrations of the mentioned compounds were detected in urine collected between eight and 10 hours from the beginning of exposure. The kinetics of excretion are considered.
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Selected References
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- Angerer J. Chronische Lösungsmittelbelastung am Arbeitsplatz. V. Chromatographische Methoden zur Bestimmung von Phenolen im Harn. Int Arch Occup Environ Health. 1979 Jan 15;42(3-4):257–258. doi: 10.1007/BF00377780. [DOI] [PubMed] [Google Scholar]
- Angerer J. Occupational chronic exposure to organic solvents. VII. Metabolism of toluene in man. Int Arch Occup Environ Health. 1979 Mar 7;43(1):63–67. doi: 10.1007/BF00454281. [DOI] [PubMed] [Google Scholar]
- Angerer J. Occupational chronic exposure to organic solvents. XII. O-cresol excretion after toluene exposure. Int Arch Occup Environ Health. 1985;56(4):323–328. doi: 10.1007/BF00405273. [DOI] [PubMed] [Google Scholar]
- Bieniek G., Wilczok T. Separation and determination of phenol, alpha-naphthol m- and p-, o-cresols and 2,5-xylenol, and catechol in the urine after mixed exposure to phenol, naphthalene, cresols, and xylenols. Br J Ind Med. 1986 Aug;43(8):570–571. doi: 10.1136/oem.43.8.570. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Drummond L., Luck R., Afacan A. S., Wilson H. K. Biological monitoring of workers exposed to benzene in the coke oven industry. Br J Ind Med. 1988 Apr;45(4):256–261. doi: 10.1136/oem.45.4.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Døssing M., Aelum J. B., Hansen S. H., Lundqvist G. R., Andersen N. T. Urinary hippuric acid and orthocresol excretion in man during experimental exposure to toluene. Br J Ind Med. 1983 Nov;40(4):470–473. doi: 10.1136/oem.40.4.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hasegawa K., Shiojima S., Koizumi A., Ikeda M. Hippuric acid and o-cresol in the urine of workers exposed to toluene. Int Arch Occup Environ Health. 1983;52(3):197–208. doi: 10.1007/BF00526518. [DOI] [PubMed] [Google Scholar]
- Inoue O., Seiji K., Kasahara M., Nakatsuka H., Watanabe T., Yin S. G., Li G. L., Jin C., Cai S. X., Wang X. Z. Quantitative relation of urinary phenol levels to breathzone benzene concentrations: a factory survey. Br J Ind Med. 1986 Oct;43(10):692–697. doi: 10.1136/oem.43.10.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nise G. Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing. Int Arch Occup Environ Health. 1992;63(6):377–381. doi: 10.1007/BF00386931. [DOI] [PubMed] [Google Scholar]
- Paradowski M., Jakubowski M., Podoski A. Toksykokinetyka benzenu u ludzi. Wydalanie fenolu z moczem i benzenu z powietrzem wydechowym po jednorazowej i czterodniowej ekspozycji inhalacyjnej. Med Pr. 1984;35(2):85–96. [PubMed] [Google Scholar]
- Piotrowski J. K. Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine. Br J Ind Med. 1971 Apr;28(2):172–178. doi: 10.1136/oem.28.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sedivec V., Flek J. The absorption, metabolism, and excretion of xylenes in man. Int Arch Occup Environ Health. 1976 Jul 5;37(3):205–217. doi: 10.1007/BF00378419. [DOI] [PubMed] [Google Scholar]
