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. 1994 Jun;51(6):397–399. doi: 10.1136/oem.51.6.397

Occupational asthma in salbutamol process workers.

R M Agius 1, A G Davison 1, E R Hawkins 1, A J Newman Taylor 1
PMCID: PMC1127995  PMID: 8044231

Abstract

Occupational asthma after exposure to salbutamol in the pharmaceutical industry has not been previously reported. The occurrence of occupational asthma is described in two pharmaceutical process workers who were likely to have inhaled doses appreciably in excess of the therapeutic dose range. The findings do not lead to an unequivocal conclusion on the mechanism of the asthma but it was probably a pharmacological consequence of high exposure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agius R. Occupational exposure limits for therapeutic substances. Ann Occup Hyg. 1989;33(4):555–562. doi: 10.1093/annhyg/33.4.555. [DOI] [PubMed] [Google Scholar]
  2. Burge P. S., O'Brien I. M., Harries M. G. Peak flow rate records in the diagnosis of occupational asthma due to colophony. Thorax. 1979 Jun;34(3):308–316. doi: 10.1136/thx.34.3.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chapman I. D., Buchheit K. H., Manley P., Morley J. Active enantiomers may cause adverse effects in asthma. Trends Pharmacol Sci. 1992 Jun;13(6):231–232. doi: 10.1016/0165-6147(92)90071-d. [DOI] [PubMed] [Google Scholar]
  4. Conolly M. E., Tashkin D. P., Hui K. K., Littner M. R., Wolfe R. N. Selective subsensitization of beta-adrenergic receptors in central airways of asthmatics and normal subjects during long-term therapy with inhaled salbutamol. J Allergy Clin Immunol. 1982 Dec;70(6):423–431. doi: 10.1016/0091-6749(82)90004-5. [DOI] [PubMed] [Google Scholar]
  5. Fawcett I. W., Pepys J., Erooga M. A. Asthma due to 'glycyl compound' powder--an intermediate in production of salbutamol. Clin Allergy. 1976 Jul;6(4):405–409. doi: 10.1111/j.1365-2222.1976.tb01923.x. [DOI] [PubMed] [Google Scholar]
  6. Galland B. C., Blackman J. G. Enhancement of airway reactivity to histamine by isoprenaline and related beta-adrenoceptor agonists in the guinea-pig. Br J Pharmacol. 1993 Apr;108(4):1016–1023. doi: 10.1111/j.1476-5381.1993.tb13499.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Harvey J. E., Tattersfield A. E. Airway response to salbutamol: effect of regular salbutamol inhalations in normal, atopic, and asthmatic subjects. Thorax. 1982 Apr;37(4):280–287. doi: 10.1136/thx.37.4.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Holgate S. T., Stubbs W. A., Wood P. J., McCaughey E. S., Alberti K. G., Tattersfield A. E. Airway and metabolic resistance to intravenous salbutamol: a study in normal man. Clin Sci (Lond) 1980 Sep;59(3):155–161. doi: 10.1042/cs0590155. [DOI] [PubMed] [Google Scholar]
  9. Hoshiko K., Morley J. Exacerbation of airway hyperreactivity by (+/-)salbutamol in sensitized guinea pig. Jpn J Pharmacol. 1993 Oct;63(2):159–163. doi: 10.1254/jjp.63.159. [DOI] [PubMed] [Google Scholar]
  10. van Schayck C. P., Graafsma S. J., Visch M. B., Dompeling E., van Weel C., van Herwaarden C. L. Increased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitization to salbutamol. J Allergy Clin Immunol. 1990 Nov;86(5):793–800. doi: 10.1016/s0091-6749(05)80185-x. [DOI] [PubMed] [Google Scholar]

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