Abstract
OBJECTIVES--22 workers, exposed to potassium aluminium tetrafluoride used as flux for soldering aluminium, were studied as clinical outpatients for symptoms of irritation of the nose, eye, skin, and airways. METHODS--16 volunteered for spirometry with methacholine provocation test including a test for small airways function by volume of trapped gas (VTG). RESULTS--Median (range) latency time before respiratory symptoms developed was 6 (1-60) months. Symptoms of airways irritation diminished in all subjects after flux exposure ended. The FEV1 was within the normal range in 16 of 17 subjects before the methacholine provocation test. The FEV1 decreased by > or = 20% in two out of 16 subjects after the 0.1% methacholine provocation. Four out of the 17 subjects had a high VTG before methacholine provocation. After inhalation of 0.1% methacholine eight out of 16 subjects (50%) had an abnormal increase of VTG indicating hyperreactivity in small airways. DISCUSSION--Potassium aluminium tetrafluoride flux seems to induce an increase of bronchial reactivity in small airways. A setting of an occupational standard for potassium aluminium tetrafluoride is proposed.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Christensson P., Arborelius M., Jr, Kautto R. Volume of trapped gas in lungs of healthy humans. J Appl Physiol Respir Environ Exerc Physiol. 1981 Jul;51(1):172–175. doi: 10.1152/jappl.1981.51.1.172. [DOI] [PubMed] [Google Scholar]
- Dahlqvist M., Alexandersson R., Nielsen J., Hedenstierna G. Single and multiple breath nitrogen wash-out--closing volume and volume of trapped gas for detection of early airway obstruction. Clin Physiol. 1989 Aug;9(4):389–398. doi: 10.1111/j.1475-097x.1989.tb00992.x. [DOI] [PubMed] [Google Scholar]
- Hjortsberg U., Orbaek P., Arborelius M., Jr Small airway hyperreactivity among lifelong non-atopic non-smokers exposed to isocyanates. Br J Ind Med. 1987 Dec;44(12):824–828. doi: 10.1136/oem.44.12.824. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larsson K., Eklund A., Arns R., Löwgren H., Nyström J., Sundström G., Tornling G. Lung function and bronchial reactivity in aluminum potroom workers. Scand J Work Environ Health. 1989 Aug;15(4):296–301. doi: 10.5271/sjweh.1850. [DOI] [PubMed] [Google Scholar]
- Leurs R., Bast A., Timmerman H. Fluoride is a contractile agent of guinea pig airway smooth muscle. Gen Pharmacol. 1991;22(4):631–636. doi: 10.1016/0306-3623(91)90068-h. [DOI] [PubMed] [Google Scholar]
- MCCANN J. K. HEALTH HAZARD FROM FLUX USED IN JOINING ALUMINIUM ELECTRICITY CABLES. Ann Occup Hyg. 1964 Sep;7:261–268. doi: 10.1093/annhyg/7.3.261. [DOI] [PubMed] [Google Scholar]
- O'Connor G. T., Sparrow D., Weiss S. T. The role of allergy and nonspecific airway hyperresponsiveness in the pathogenesis of chronic obstructive pulmonary disease. Am Rev Respir Dis. 1989 Jul;140(1):225–252. doi: 10.1164/ajrccm/140.1.225. [DOI] [PubMed] [Google Scholar]
- Sarić M., Godnić-Cvar J., Gomzi M., Stilinović L. The role of atopy in potroom workers' asthma. Am J Ind Med. 1986;9(3):239–242. doi: 10.1002/ajim.4700090306. [DOI] [PubMed] [Google Scholar]
- Simonsson B. G., Sjöberg A., Rolf C., Haeger-Aronsen B. Acute and long-term airway hyperreactivity in aluminium-salt exposed workers with nocturnal asthma. Eur J Respir Dis. 1985 Feb;66(2):105–118. [PubMed] [Google Scholar]
- Sterling G. M. Asthma due to aluminium soldering flux. Thorax. 1967 Nov;22(6):533–537. doi: 10.1136/thx.22.6.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Søyseth V., Kongerud J. Prevalence of respiratory disorders among aluminium potroom workers in relation to exposure to fluoride. Br J Ind Med. 1992 Feb;49(2):125–130. doi: 10.1136/oem.49.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Vries K., Löwenberg A., Coster van Voorhout H. E., Ebels J. H. Langzeitbeobachtungen bei Fluorwasserstoffexposition. Pneumonologie. 1974;150(2-4):149–154. doi: 10.1007/BF02179312. [DOI] [PubMed] [Google Scholar]