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. 1994 Nov;51(11):735–738. doi: 10.1136/oem.51.11.735

Effect of bis (tributyl tin) oxide on permeability of the blood-brain barrier: a transient increase.

K Hara 1, M Yoshizuka 1, Y Doi 1, S Fujimoto 1
PMCID: PMC1128096  PMID: 7849849

Abstract

OBJECTIVES--To study the effect of bis (tributyl tin) oxide (TBTO) on permeability of the blood-brain barrier. METHODS--Electron microscopy and an x ray microanalyser with lanthanum chloride as a tracer were used, and blood tin concentrations were determined with an atomic absorption spectrophotometer. Adult male wistar rats received 0.05 ml/kg body weight of TBTO orally. RESULTS--A transient increase in paracellular permeability at the blood-brain barrier was found 2 h after the dose of TBTO. Electron dense lanthanum deposits penetrated tight junctions of the endothelia and permeated the subendothelial space. The x ray microprobe data showed an accumulation of TBTO at the tight junctions at 2 h. Leakage of tracer did not occur at 4 h, but oedematous changes in the surrounding glial cells were prominent between 4 and 8 h and had almost returned to normal by 24 h. By atomic absorption analysis, it was seen that blood tin concentrations rapidly increased at 1 h and rose to a maximum peak at 8 h, then gradually decreased to reach zero at 24 h. CONCLUSIONS--Accumulated TBTO at tight junctions could have caused the temporary replacement of calcium ion by tin, which induces a transient increase in paracellular permeability throughout the blood-brain barrier.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALAJOUANINE T., DEROBERT L., THIEFFRY S. Etude clinique d'ensemble de 210 cas d'intoxication par les sels organiques d'étain. Rev Neurol (Paris) 1958 Feb;98(2):85–96. [PubMed] [Google Scholar]
  2. Boyer I. J. Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. Toxicology. 1989 May 15;55(3):253–298. doi: 10.1016/0300-483x(89)90018-8. [DOI] [PubMed] [Google Scholar]
  3. Claude P., Goodenough D. A. Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia. J Cell Biol. 1973 Aug;58(2):390–400. doi: 10.1083/jcb.58.2.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heimark R. L., Degner M., Schwartz S. M. Identification of a Ca2(+)-dependent cell-cell adhesion molecule in endothelial cells. J Cell Biol. 1990 May;110(5):1745–1756. doi: 10.1083/jcb.110.5.1745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hirano A., Zimmerman H. M., Levine S. Intramyelinic and extracellular spaces in triethyltin intoxication. J Neuropathol Exp Neurol. 1968 Oct;27(4):571–580. [PubMed] [Google Scholar]
  6. Hultström D., Forssén M., Pettersson A., Tengvar C., Jarild M., Olsson Y. Vascular permeability in acute triethyltin-induced brain edema studied with FITC-dextrans, sodium fluorescein and horseradish peroxidase as tracers. Acta Neurol Scand. 1984 May;69(5):255–263. doi: 10.1111/j.1600-0404.1984.tb07810.x. [DOI] [PubMed] [Google Scholar]
  7. Inoue T., Nagara H., Kondo A., Fukui M., Tateishi J. Effects of intracarotid hyperosmolar mannitol in triethyl tin (TET)-induced rat brain edema--preservation of blood-brain barrier (BBB) in TET edema. Brain Res. 1987 Jun 30;414(2):309–313. doi: 10.1016/0006-8993(87)90011-4. [DOI] [PubMed] [Google Scholar]
  8. Kodavanti P. R., Cameron J. A., Yallapragada P. R., Vig P. J., Desaiah D. Inhibition of Ca2+ transport associated with cAMP-dependent protein phosphorylation in rat cardiac sarcoplasmic reticulum by triorganotins. Arch Toxicol. 1991;65(4):311–317. doi: 10.1007/BF01968965. [DOI] [PubMed] [Google Scholar]
  9. Machen T. E., Erlij D., Wooding F. B. Permeable junctional complexes. The movement of lanthanum across rabbit gallbladder and intestine. J Cell Biol. 1972 Aug;54(2):302–312. doi: 10.1083/jcb.54.2.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ross W. D., Emmett E. A., Steiner J., Tureen R. Neurotoxic effects of occupational exposure to organotins. Am J Psychiatry. 1981 Aug;138(8):1092–1095. doi: 10.1176/ajp.138.8.1092. [DOI] [PubMed] [Google Scholar]
  11. Yoshizuka M., Hara K., Doi Y., Mori N., Yokoyama M., Ono E., Fujimoto S. The toxic effects of bis (tributyltin) oxide on the rat thoracic aorta. Histol Histopathol. 1992 Jul;7(3):445–449. [PubMed] [Google Scholar]

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