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. 1995 Oct;52(10):625–633. doi: 10.1136/oem.52.10.625

Exposure assessment in industry specific retrospective occupational epidemiology studies.

N S Seixas 1, H Checkoway 1
PMCID: PMC1128326  PMID: 7489051

Abstract

Quantitative estimation of exposure for occupational epidemiology studies has received increasing attention in recent years and, as a result, a body of methodological literature has begun to take form. This paper reviews the generic issues in the methodology of exposure assessment, particularly methods for quantitative retrospective assessment studies. A simple framework, termed an exposure data matrix (EDM), for defining and analysing exposure data is proposed and discussed in terms of the definition of matrix dimensions and scales. Several methods for estimation, interpolation, and extrapolation, ranging from subjective ratings to quantitative statistical modelling are presented and discussed. The various approaches to exposure assessment based on the EDM concept are illustrated with studies of lung disease among coal miners and other dust and chemically induced chronic occupational diseases. The advantages of validated statistical models are emphasised. The importance of analysis and control of errors in exposure assessments, and integration of the exposure assessment and exposure-response processes, especially for emerging occupational health issues, is emphasised.

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Selected References

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  1. Armstrong B. G., Tremblay C. G., Cyr D., Thériault G. P. Estimating the relationship between exposure to tar volatiles and the incidence of bladder cancer in aluminum smelter workers. Scand J Work Environ Health. 1986 Oct;12(5):486–493. doi: 10.5271/sjweh.2109. [DOI] [PubMed] [Google Scholar]
  2. Attfield M. D., Morring K. The derivation of estimated dust exposures for U.S. coal miners working before 1970. Am Ind Hyg Assoc J. 1992 Apr;53(4):248–255. doi: 10.1080/15298669291359609. [DOI] [PubMed] [Google Scholar]
  3. Ayer H. E., Dement J. M., Busch K. A., Ashe H. B., Levadie B. T., Burgess W. A., DiBerardinis L. A monumental study--reconstruction of a 1920 granite shed. Am Ind Hyg Assoc J. 1973 May;34(5):206–211. doi: 10.1080/0002889738506835. [DOI] [PubMed] [Google Scholar]
  4. Ballew M. A., Kriebel D., Smith T. J. Epidemiologic application of a dosimetric model of dust overload. Am J Epidemiol. 1995 Apr 1;141(7):690–696. doi: 10.1093/oxfordjournals.aje.a117486. [DOI] [PubMed] [Google Scholar]
  5. Checkoway H., Heyer N. J., Demers P. A., Breslow N. E. Mortality among workers in the diatomaceous earth industry. Br J Ind Med. 1993 Jul;50(7):586–597. doi: 10.1136/oem.50.7.586. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cherrie J., Krantz S., Schneider T., Ohberg I., Kamstrup O., Linander W. An experimental simulation of an early rock wool/slag wool production process. Ann Occup Hyg. 1987;31(4B):583–593. doi: 10.1093/annhyg/31.4b.583. [DOI] [PubMed] [Google Scholar]
  7. Corn M., Esmen N. A. Workplace exposure zones for classification of employee exposures to physical and chemical agents. Am Ind Hyg Assoc J. 1979 Jan;40(1):47–57. doi: 10.1080/15298667991429318. [DOI] [PubMed] [Google Scholar]
  8. Dement J. M., Harris R. L., Jr, Symons M. J., Shy C. M. Exposures and mortality among chrysotile asbestos workers. Part I: exposure estimates. Am J Ind Med. 1983;4(3):399–419. doi: 10.1002/ajim.4700040303. [DOI] [PubMed] [Google Scholar]
  9. Dodgson J., Cherrie J., Groat S. Estimates of past exposure to respirable man-made mineral fibres in the European insulation wool industry. Ann Occup Hyg. 1987;31(4B):567–582. doi: 10.1093/annhyg/31.4b.567. [DOI] [PubMed] [Google Scholar]
  10. Dosemeci M., McLaughlin J. K., Chen J. Q., Hearl F., McCawley M., Wu Z., Chen R. G., Peng K. L., Chen A. L., Rexing S. H. Indirect validation of a retrospective method of exposure assessment used in a nested case-control study of lung cancer and silica exposure. Occup Environ Med. 1994 Feb;51(2):136–138. doi: 10.1136/oem.51.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Eisen E. A., Smith T. J., Wegman D. H., Louis T. A., Froines J. Estimation of long term dust exposures in the Vermont granite sheds. Am Ind Hyg Assoc J. 1984 Feb;45(2):89–94. doi: 10.1080/15298668491399424. [DOI] [PubMed] [Google Scholar]
  12. Esmen N. Retrospective industrial hygiene surveys. Am Ind Hyg Assoc J. 1979 Jan;40(1):58–65. doi: 10.1080/15298667991429327. [DOI] [PubMed] [Google Scholar]
  13. Greife A. L., Hornung R. W., Stayner L. G., Steenland K. N. Development of a model for use in estimating exposure to ethylene oxide in a retrospective cohort mortality study. Scand J Work Environ Health. 1988;14 (Suppl 1):29–30. [PubMed] [Google Scholar]
  14. Hallock M. F., Smith T. J., Woskie S. R., Hammond S. K. Estimation of historical exposures to machining fluids in the automotive industry. Am J Ind Med. 1994 Nov;26(5):621–634. doi: 10.1002/ajim.4700260505. [DOI] [PubMed] [Google Scholar]
  15. Hornung R. W., Greife A. L., Stayner L. T., Steenland N. K., Herrick R. F., Elliott L. J., Ringenburg V. L., Morawetz J. Statistical model for prediction of retrospective exposure to ethylene oxide in an occupational mortality study. Am J Ind Med. 1994 Jun;25(6):825–836. doi: 10.1002/ajim.4700250607. [DOI] [PubMed] [Google Scholar]
  16. Kauppinen T., Partanen T. Use of plant- and period-specific job-exposure matrices in studies on occupational cancer. Scand J Work Environ Health. 1988 Jun;14(3):161–167. doi: 10.5271/sjweh.1936. [DOI] [PubMed] [Google Scholar]
  17. Kromhout H., Oostendorp Y., Heederik D., Boleij J. S. Agreement between qualitative exposure estimates and quantitative exposure measurements. Am J Ind Med. 1987;12(5):551–562. doi: 10.1002/ajim.4700120509. [DOI] [PubMed] [Google Scholar]
  18. Rappaport S. M., Kromhout H., Symanski E. Variation of exposure between workers in homogeneous exposure groups. Am Ind Hyg Assoc J. 1993 Nov;54(11):654–662. doi: 10.1080/15298669391355198. [DOI] [PubMed] [Google Scholar]
  19. Rinsky R. A., Smith A. B., Hornung R., Filloon T. G., Young R. J., Okun A. H., Landrigan P. J. Benzene and leukemia. An epidemiologic risk assessment. N Engl J Med. 1987 Apr 23;316(17):1044–1050. doi: 10.1056/NEJM198704233161702. [DOI] [PubMed] [Google Scholar]
  20. Salvan A., Stayner L., Steenland K., Smith R. Selecting an exposure lag period. Epidemiology. 1995 Jul;6(4):387–390. doi: 10.1097/00001648-199507000-00010. [DOI] [PubMed] [Google Scholar]
  21. Seixas N. S., Robins T. G., Becker M. A novel approach to the characterization of cumulative exposure for the study of chronic occupational disease. Am J Epidemiol. 1993 Feb 15;137(4):463–471. doi: 10.1093/oxfordjournals.aje.a116695. [DOI] [PubMed] [Google Scholar]
  22. Seixas N. S., Robins T. G., Rice C. H., Moulton L. H. Assessment of potential biases in the application of MSHA respirable coal mine dust data to an epidemiologic study. Am Ind Hyg Assoc J. 1990 Oct;51(10):534–540. doi: 10.1080/15298669091370059. [DOI] [PubMed] [Google Scholar]
  23. Smith T. J. Exposure assessment for occupational epidemiology. Am J Ind Med. 1987;12(3):249–268. doi: 10.1002/ajim.4700120303. [DOI] [PubMed] [Google Scholar]
  24. Stewart W. F., Stewart P. A. Occupational case-control studies: I. Collecting information on work histories and work-related exposures. Am J Ind Med. 1994 Sep;26(3):297–312. doi: 10.1002/ajim.4700260304. [DOI] [PubMed] [Google Scholar]
  25. Teschke K., Hertzman C., Dimich-Ward H., Ostry A., Blair J., Hershler R. A comparison of exposure estimates by worker raters and industrial hygienists. Scand J Work Environ Health. 1989 Dec;15(6):424–429. doi: 10.5271/sjweh.1831. [DOI] [PubMed] [Google Scholar]
  26. Thomas D., Stram D., Dwyer J. Exposure measurement error: influence on exposure-disease. Relationships and methods of correction. Annu Rev Public Health. 1993;14:69–93. doi: 10.1146/annurev.pu.14.050193.000441. [DOI] [PubMed] [Google Scholar]

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