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. 1995 Oct;52(10):654–660. doi: 10.1136/oem.52.10.654

Lung function and chronic respiratory symptoms of pig farmers: focus on exposure to endotoxins and ammonia and use of disinfectants.

L Preller 1, D Heederik 1, J S Boleij 1, P F Vogelzang 1, M J Tielen 1
PMCID: PMC1128330  PMID: 7489055

Abstract

OBJECTIVES--The prevalence of chronic respiratory symptoms among pig farmers is known to be high, but the aetiology of these symptoms is not yet unravelled. Long term average exposure to dust was evaluated, endotoxins and ammonia and use of disinfectants were compared with chronic respiratory symptoms and depressed base line lung function. METHODS--A cross sectional study was performed among 194 Dutch pig farmers, of whom 100 had not and 94 had chronic respiratory symptoms. Exposure-response relations were evaluated with multiple logistic and linear regression analysis. Estimates of long term average exposure were based on two personal exposure measurements, taken on one day in summer and one day in winter. Information on use of disinfectants and disinfection procedures was assessed by a walk through survey and interview by telephone. RESULTS--Exposure to dust, endotoxins, and ammonia were not related to chronic respiratory symptoms. Duration of the disinfection procedure and pressure used at disinfection were strongly and positively related to chronic respiratory symptoms. A significant inverse association between base line lung function and endotoxin exposure was found only among asymptomatic farmers. Ammonia exposure and duration of the disinfection procedure were significantly associated with base line lung function in the entire population. CONCLUSION--Results suggest that use of disinfectants is an important aetiological factor in chronic respiratory health effects of pig farmers. This factor has not been studied before. Results also suggest an aetiological role for exposure to endotoxins and ammonia in development of chronic respiratory health effects, but longitudinal studies with detailed exposure assessment strategies are required to assess their roles.

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Selected References

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  1. Benson W. G. Exposure to glutaraldehyde. J Soc Occup Med. 1984 May;34(2):63–64. doi: 10.1093/occmed/34.3.63. [DOI] [PubMed] [Google Scholar]
  2. Bernstein J. A., Stauder T., Bernstein D. I., Bernstein I. L. A combined respiratory and cutaneous hypersensitivity syndrome induced by work exposure to quaternary amines. J Allergy Clin Immunol. 1994 Aug;94(2 Pt 1):257–259. doi: 10.1016/0091-6749(94)90048-5. [DOI] [PubMed] [Google Scholar]
  3. Blomqvist A. M., Axelsson I. G., Danielsson D., Kiviloog J., Ulander A., Zetterström O. Atopic allergy to chloramine-T and the demonstration of specific IgE antibodies by the radioallergosorbent test. Int Arch Occup Environ Health. 1991;63(5):363–365. doi: 10.1007/BF00381589. [DOI] [PubMed] [Google Scholar]
  4. Bongers P., Houthuijs D., Remijn B., Brouwer R., Biersteker K. Lung function and respiratory symptoms in pig farmers. Br J Ind Med. 1987 Dec;44(12):819–823. doi: 10.1136/oem.44.12.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bourne M. S., Flindt M. L., Walker J. M. Asthma due to industrial use of chloramine. Br Med J. 1979 Jul 7;2(6181):10–12. doi: 10.1136/bmj.2.6181.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Burge P. S., Harries M. G., Lam W. K., O'Brien I. M., Patchett P. A. Occupational asthma due to formaldehyde. Thorax. 1985 Apr;40(4):255–260. doi: 10.1136/thx.40.4.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Burge P. S., Richardson M. N. Occupational asthma due to indirect exposure to lauryl dimethyl benzyl ammonium chloride used in a floor cleaner. Thorax. 1994 Aug;49(8):842–843. doi: 10.1136/thx.49.8.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chan-Yeung M., McMurren T., Catonio-Begley F., Lam S. Occupational asthma in a technologist exposed to glutaraldehyde. J Allergy Clin Immunol. 1993 May;91(5):974–978. doi: 10.1016/0091-6749(93)90209-x. [DOI] [PubMed] [Google Scholar]
  9. Choudat D., Goehen M., Korobaeff M., Boulet A., Dewitte J. D., Martin M. H. Respiratory symptoms and bronchial reactivity among pig and dairy farmers. Scand J Work Environ Health. 1994 Feb;20(1):48–54. doi: 10.5271/sjweh.1429. [DOI] [PubMed] [Google Scholar]
  10. Cinkotai F. F., Gibbs A. C., Sharpe T. C. A comparison of exposure to airborne dust in cotton processing plants estimated from personal and workzone samples. Ann Occup Hyg. 1984;28(3):347–352. doi: 10.1093/annhyg/28.3.347. [DOI] [PubMed] [Google Scholar]
  11. Dijkman J. H., Vooren P. H., Kramps J. A. Occupational asthma due to inhalation of chloramine-T. I. Clinical observations and inhalation-provocation studies. Int Arch Allergy Appl Immunol. 1981;64(4):422–427. doi: 10.1159/000232722. [DOI] [PubMed] [Google Scholar]
  12. Donham K. J., Scallon L. J., Popendorf W., Treuhaft M. W., Roberts R. C. Characterization of dusts collected from swine confinement buildings. Am Ind Hyg Assoc J. 1986 Jul;47(7):404–410. doi: 10.1080/15298668691389955. [DOI] [PubMed] [Google Scholar]
  13. Donham K., Haglind P., Peterson Y., Rylander R., Belin L. Environmental and health studies of farm workers in Swedish swine confinement buildings. Br J Ind Med. 1989 Jan;46(1):31–37. doi: 10.1136/oem.46.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Dosman J. A., Graham B. L., Hall D., Pahwa P., McDuffie H. H., Lucewicz M., To T. Respiratory symptoms and alterations in pulmonary function tests in swine producers in Saskatchewan: results of a survey of farmers. J Occup Med. 1988 Sep;30(9):715–720. [PubMed] [Google Scholar]
  15. Heederik D., Brouwer R., Biersteker K., Boleij J. S. Relationship of airborne endotoxin and bacteria levels in pig farms with the lung function and respiratory symptoms of farmers. Int Arch Occup Environ Health. 1991;62(8):595–601. doi: 10.1007/BF00381114. [DOI] [PubMed] [Google Scholar]
  16. Hollander A., Heederik D., Versloot P., Douwes J. Inhibition and enhancement in the analysis of airborne endotoxin levels in various occupational environments. Am Ind Hyg Assoc J. 1993 Nov;54(11):647–653. doi: 10.1080/15298669391355189. [DOI] [PubMed] [Google Scholar]
  17. Holness D. L., O'Blenis E. L., Sass-Kortsak A., Pilger C., Nethercott J. R. Respiratory effects and dust exposures in hog confinement farming. Am J Ind Med. 1987;11(5):571–580. doi: 10.1002/ajim.4700110509. [DOI] [PubMed] [Google Scholar]
  18. Holness D. L., Purdham J. T., Nethercott J. R. Acute and chronic respiratory effects of occupational exposure to ammonia. Am Ind Hyg Assoc J. 1989 Dec;50(12):646–650. doi: 10.1080/15298668991375308. [DOI] [PubMed] [Google Scholar]
  19. Horvath E. P., Jr, Anderson H., Jr, Pierce W. E., Hanrahan L., Wendlick J. D. Effects of formaldehyde on the mucous membranes and lungs. A study of an industrial population. JAMA. 1988 Feb 5;259(5):701–707. [PubMed] [Google Scholar]
  20. Malaka T., Kodama A. M. Respiratory health of plywood workers occupationally exposed to formaldehyde. Arch Environ Health. 1990 Sep-Oct;45(5):288–294. doi: 10.1080/00039896.1990.10118748. [DOI] [PubMed] [Google Scholar]
  21. Norbäck D. Skin and respiratory symptoms from exposure to alkaline glutaraldehyde in medical services. Scand J Work Environ Health. 1988 Dec;14(6):366–371. [PubMed] [Google Scholar]
  22. Schwartz D. A., Landas S. K., Lassise D. L., Burmeister L. F., Hunninghake G. W., Merchant J. A. Airway injury in swine confinement workers. Ann Intern Med. 1992 Apr 15;116(8):630–635. doi: 10.7326/0003-4819-116-8-630. [DOI] [PubMed] [Google Scholar]
  23. Smid T., Heederik D., Mensink G., Houba R., Boleij J. S. Exposure to dust, endotoxins, and fungi in the animal feed industry. Am Ind Hyg Assoc J. 1992 Jun;53(6):362–368. doi: 10.1080/15298669291359780. [DOI] [PubMed] [Google Scholar]
  24. Standardized lung function testing. Report working party. Bull Eur Physiopathol Respir. 1983 Jul;19 (Suppl 5):1–95. [PubMed] [Google Scholar]
  25. Wass U., Belin L., Eriksson N. E. Immunological specificity of chloramine-T-induced IgE antibodies in serum from a sensitized worker. Clin Exp Allergy. 1989 Jul;19(4):463–471. doi: 10.1111/j.1365-2222.1989.tb02415.x. [DOI] [PubMed] [Google Scholar]
  26. Zejda J. E., Barber E., Dosman J. A., Olenchock S. A., McDuffie H. H., Rhodes C., Hurst T. Respiratory health status in swine producers relates to endotoxin exposure in the presence of low dust levels. J Occup Med. 1994 Jan;36(1):49–56. [PubMed] [Google Scholar]
  27. Zejda J. E., Hurst T. S., Rhodes C. S., Barber E. M., McDuffie H. H., Dosman J. A. Respiratory health of swine producers. Focus on young workers. Chest. 1993 Mar;103(3):702–709. doi: 10.1378/chest.103.3.702. [DOI] [PubMed] [Google Scholar]
  28. Zhou C., Hurst T. S., Cockcroft D. W., Dosman J. A. Increased airways responsiveness in swine farmers. Chest. 1991 Apr;99(4):941–944. doi: 10.1378/chest.99.4.941. [DOI] [PubMed] [Google Scholar]

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