Table-3.
The checkerboard results of the effect of combinations of the peptide KW-23 with the antibiotics used in the study against the both bacterial strains used.
| Bacteria strains | Antibiotics | MIC | FICI* | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Antibiotics | Antibiotics/KW-23 | KW-23 | KW-23/antibiotics | |||
| Control P. aeruginosa | Levofloxacin | 9 | 2 | 4.5 | 1.5 | 0.6 |
| Chloramphenicol | 80 | 15 | 4.5 | 2 | 0.63 | |
| Rifampicin | 15 | 3 | 4.5 | 0.5 | 0.3 | |
| Amoxicillin | 25 | 10 | 4.5 | 0.25 | 0.45 | |
| Clarithromycin | 125 | 65 | 4.5 | 2 | 0.96 | |
| Doxycycline | 6 | 2 | 4.5 | 0.125 | 0.36 | |
| Vancomycin | 200 | 175 | 4.5 | 3.5 | 1.65 | |
| Cefixime | 6 | 0.5 | 4.5 | 1 | 0.3 | |
| Gentamicin | 2 | 0.125 | 4.5 | 0.025 | 0.07 | |
| MDR P. aeruginosa | Levofloxacin | 30 | 15 | 20 | 10 | 1 |
| Chloramphenicol | 150 | 60 | 20 | 15 | 1.15 | |
| Rifampicin | 50 | 20 | 20 | 5 | 0.65 | |
| Amoxicillin | 200 | 120 | 20 | 18 | 1.5 | |
| Clarithromycin | 125 | 80 | 20 | 5 | 0.9 | |
| Doxycycline | 34 | 10 | 20 | 2 | 0.4 | |
| Vancomycin | 260 | 150 | 20 | 15 | 1.3 | |
| Cefixime | 82 | 40 | 20 | 12 | 1.08 | |
| Gentamicin | 20 | 5 | 20 | 0.5 | 0.27 | |
Synergistic (FIC ≤ 0.5), additive (FIC 0.5 < FIC ≤ 1), indifferent (1 < FIC ≤ 4), or antagonist (FIC > 4). FICI=Fractional inhibitory concentration index, P. aeruginosa=Pseudomonas aeruginosa, MIC=Minimum inhibitory concentration, MDR=Multidrug resistant