Skip to main content
. 2024 Jun 15;21(4):e00384. doi: 10.1016/j.neurot.2024.e00384

Fig. 3.

Fig. 3

Acute treatment with the M1PAM VU846 at 3 ​mg/kg increased ITPC in RTT mice. A. Heat maps showing average ITPC in WT (top row) and MUT mice (bottom row) after vehicle injection (left panels), VU846 injection (middle panels), and difference in ITPC between treatment (right panels, significant differences outlined in black-dotted area, permutation testing). B. Heat maps as in A, with frequency range displayed (y-axis) restricted to the 0–10Hz range to highlight low frequency ITPC changes observed in MUT animals after VU846 injection. C. Mean ITPC (0–250 ​ms) in defined frequency bands in WT and MUT animals after vehicle injection (#p ​< ​0.05 and ##p ​< ​0.01, t-test comparing between genotypes). Mean frequency band ITPC in WT (D) and MUT (E) after vehicle or VU846 injection (∗p ​< ​0.05, paired-t-test between vehicle and VU846 injection within genotype).