Table 1.

Studies using iPSC lines from patients with LOAD and healthy control subjects.

Abnormal factor	NPCs	Neurons	Astrocytes	Microglia	Organoid/multicell	Total studies per factor	Total cell lines per factor
Lipid metabolism			TCW 202234 [8]	TCW 202234 [8]		1	8
Energy metabolism	Ryu 2021, 20227,8,35 [9]	Birnbaum 201836 [5] Chen 201837 [5]	Ryu 2021, 20227,8,35 [9]	Konttinen 201938 [3]		4	22
Oxidative stress response		Kondo 201339 [2] Hossini 201540 [1] Ochalek 201741 [4] Zhang 202042 [1] Birnbaum 201836 [5] Balez 201643 [1]	Kondo 201339 [2]	Konttinen 201938 [3] Zhang 202042 [1]	Rouleau 202044 [1]	8	18
Glutamatergic stress response		Duan 201445 [1] Balez 201643 [1] Balez 202446 [3]				3	5
Calcium flux		Duan 201445 [1] Balez 201643 [1] Balez 202446 [3]				3	5
Endo-/Phagocytosis Auto-/Mitophagy		Israel 201247 [2] Hossini 201540 [1] Fang 201948 [1] Mei 202349 [3] Verheijen 202250 [3]		Konttinen38 2019 [3] Xu 201938 [2]	Zhao 202051 [10]	8	25
Inflammatory pathway activity		Chen 201837 [5]	Jones 201752 [1] Arnaud 202217 [4]	Konttinen38 2019 [3] Xu 201953 [2] TCW 202234 [8]		6	23
Total studies	1	15	5	4	2
Total LOAD cell lines	9	32	24	14	11

Reports are organised by cell type or multicell culture (columns) and the abnormal factor observed (rows). In the boxes, studies are identified by first author and superscript citation, followed by the number of LOAD iPSC lines used in each study, in brackets. Totals of studies of each cell/culture type and LOAD lines used are provided at the bottom of each column. Total of studies of each factor and total of LOAD lines used in those studies are provided at the end of each row.