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. 1996 Dec;53(12):836–840. doi: 10.1136/oem.53.12.836

Blood lead in pregnant women in the urban slums of Lucknow, India.

S Awasthi 1, R Awasthi 1, V K Pande 1, R C Srivastav 1, H Frumkin 1
PMCID: PMC1128618  PMID: 9004930

Abstract

OBJECTIVES: To determine the concentrations of blood lead (PbB) in pregnant women in the slums of Lucknow, north India. METHODS: Of the 203 designated municipal slums in Lucknow, 70 were randomly selected for study and a cohort of 500 pregnant women was enrolled. Each participant was interviewed with questions on possible sources of exposure to lead, surrogates of nutritional status were measured, and PbB was measured. RESULTS: The mean PbB was 14.3 micrograms/dl and 19.2% of women had PbB > or = 20 micrograms/dl. PbB was not associated with age, height, weight, gestation, or history of abortions, although higher PbB was associated with higher parity. Women living inner city neighbourhoods near heavy vehicular traffic had PbB 2.2 micrograms/dl higher (95% confidence interval (95% CI) 0.8 to 3.6) than those living in other neighbourhoods. The PbB was not associated with reported use of piped water or the presence of paint in homes, and increasing PbB was unexpectedly associated with decreasing use of eye cosmetic "surma" and the duration of gestation. CONCLUSIONS: The high PbB found in this population raises concern about fetal development and points to the urgent need to reduce exposure to lead.

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Selected References

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  1. Abdullah M. A. Lead poisoning among children in Saudi Arabia. J Trop Med Hyg. 1984 Apr;87(2):67–70. [PubMed] [Google Scholar]
  2. Ali A. R., Smales O. R., Aslam M. Surma and lead poisoning. Br Med J. 1978 Sep 30;2(6142):915–916. doi: 10.1136/bmj.2.6142.915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Alkhawajah A. M. Alkohl use in Saudi Arabia. Extent of use and possible lead toxicity. Trop Geogr Med. 1992 Oct;44(4):373–377. [PubMed] [Google Scholar]
  4. Andrews K. W., Savitz D. A., Hertz-Picciotto I. Prenatal lead exposure in relation to gestational age and birth weight: a review of epidemiologic studies. Am J Ind Med. 1994 Jul;26(1):13–32. doi: 10.1002/ajim.4700260103. [DOI] [PubMed] [Google Scholar]
  5. Aslam M., Davis S. S., Healy M. A. Heavy metals in some Asian medicines and cosmetics. Public Health. 1979 Sep;93(5):274–284. doi: 10.1016/s0033-3506(79)80078-5. [DOI] [PubMed] [Google Scholar]
  6. Aslam M., Healy M. A., Davis S. S., Ali A. R. Surma and blood lead in children. Lancet. 1980 Mar 22;1(8169):658–659. doi: 10.1016/s0140-6736(80)91156-3. [DOI] [PubMed] [Google Scholar]
  7. Bellinger D., Leviton A., Allred E., Rabinowitz M. Pre- and postnatal lead exposure and behavior problems in school-aged children. Environ Res. 1994 Jul;66(1):12–30. doi: 10.1006/enrs.1994.1041. [DOI] [PubMed] [Google Scholar]
  8. Bellinger D., Leviton A., Waternaux C., Needleman H., Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med. 1987 Apr 23;316(17):1037–1043. doi: 10.1056/NEJM198704233161701. [DOI] [PubMed] [Google Scholar]
  9. Bogden J. D., Kemp F. W., Han S., Murphy M., Fraiman M., Czerniach D., Flynn C. J., Banua M. L., Scimone A., Castrovilly L. Dietary calcium and lead interact to modify maternal blood pressure, erythropoiesis, and fetal and neonatal growth in rats during pregnancy and lactation. J Nutr. 1995 Apr;125(4):990–1002. doi: 10.1093/jn/125.4.990. [DOI] [PubMed] [Google Scholar]
  10. Buchet J. P., Roels H., Hubermont G., Lauwerys R. Placental transfer of lead, mercury, cadmium, and carbon monoxide in women. II. influence of some epidemiological factors on the frequency distributions of the biological indices in maternal and umbilical cord blood. Environ Res. 1978 Jun;15(3):494–503. doi: 10.1016/0013-9351(78)90128-7. [DOI] [PubMed] [Google Scholar]
  11. Buchheim K., Noack S., Stoltenburg G., Lilienthal H., Winneke G. Developmental delay of astrocytes in hippocampus of rhesus monkeys reflects the effect of pre- and postnatal chronic low level lead exposure. Neurotoxicology. 1994 Fall;15(3):665–669. [PubMed] [Google Scholar]
  12. Chetty N., Jinabhai C. C., Green-Thompson R. W. Lead levels in maternal and umbilical cord blood at King Edward Hospital, Durban. S Afr Med J. 1993 Mar;83(3):227–227. [PubMed] [Google Scholar]
  13. Coffigny H., Thoreux-Manlay A., Pinon-Lataillade G., Monchaux G., Masse R., Soufir J. C. Effects of lead poisoning of rats during pregnancy on the reproductive system and fertility of their offspring. Hum Exp Toxicol. 1994 Apr;13(4):241–246. doi: 10.1177/096032719401300403. [DOI] [PubMed] [Google Scholar]
  14. Corpas I., Gaspar I., Martínez S., Codesal J., Candelas S., Antonio M. T. Testicular alterations in rats due to gestational and early lactational administration of lead. Reprod Toxicol. 1995 May-Jun;9(3):307–313. doi: 10.1016/0890-6238(95)97355-g. [DOI] [PubMed] [Google Scholar]
  15. Dietrich K. N., Krafft K. M., Bornschein R. L., Hammond P. B., Berger O., Succop P. A., Bier M. Low-level fetal lead exposure effect on neurobehavioral development in early infancy. Pediatrics. 1987 Nov;80(5):721–730. [PubMed] [Google Scholar]
  16. Fernando N. P., Healy M. A., Aslam M., Davis S. S., Hussein A. Lead poisoning and traditional practices: the consequences for world health. A study in Kuwait. Public Health. 1981 Sep;95(5):250–260. doi: 10.1016/s0033-3506(81)80015-7. [DOI] [PubMed] [Google Scholar]
  17. Foster W. G. Reproductive toxicity of chronic lead exposure in the female cynomolgus monkey. Reprod Toxicol. 1992;6(2):123–131. doi: 10.1016/0890-6238(92)90113-8. [DOI] [PubMed] [Google Scholar]
  18. Fuentes-Aguilar L., Soto-Mora C. Influence of lead on pregnant women in metropolitan Mexico City. Bull Environ Contam Toxicol. 1993 Apr;50(4):533–539. doi: 10.1007/BF00191242. [DOI] [PubMed] [Google Scholar]
  19. Fullmer C. S. Intestinal interactions of lead and calcium. Neurotoxicology. 1992 Winter;13(4):799–807. [PubMed] [Google Scholar]
  20. Gogte S. T., Basu N., Sinclair S., Ghai O. P., Bhide N. K. Blood lead levels of children with pica and surma use. Indian J Pediatr. 1991 Jul-Aug;58(4):513–519. doi: 10.1007/BF02750933. [DOI] [PubMed] [Google Scholar]
  21. Huel G., Tubert P., Frery N., Moreau T., Dreyfus J. Joint effect of gestational age and maternal lead exposure on psychomotor development of the child at six years. Neurotoxicology. 1992 Spring;13(1):249–254. [PubMed] [Google Scholar]
  22. Kristensen P., Eilertsen E., Einarsdóttir E., Haugen A., Skaug V., Ovrebø S. Fertility in mice after prenatal exposure to benzo[a]pyrene and inorganic lead. Environ Health Perspect. 1995 Jun;103(6):588–590. doi: 10.1289/ehp.95103588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Lagerkvist B. J., Söderberg H. A., Nordberg G. F., Ekesrydh S., Englyst V. Biological monitoring of arsenic, lead and cadmium in occupationally and environmentally exposed pregnant women. Scand J Work Environ Health. 1993;19 (Suppl 1):50–53. [PubMed] [Google Scholar]
  24. Legare M. E., Castiglioni A. J., Jr, Rowles T. K., Calvin J. A., Snyder-Armstead C., Tiffany-Castiglioni E. Morphological alterations of neurons and astrocytes in guinea pigs exposed to low levels of inorganic lead. Neurotoxicology. 1993 Spring;14(1):77–80. [PubMed] [Google Scholar]
  25. Leviton A., Bellinger D., Allred E. N., Rabinowitz M., Needleman H., Schoenbaum S. Pre- and postnatal low-level lead exposure and children's dysfunction in school. Environ Res. 1993 Jan;60(1):30–43. doi: 10.1006/enrs.1993.1003. [DOI] [PubMed] [Google Scholar]
  26. Mahaffey K. R. Biokinetics of lead during pregnancy. Fundam Appl Toxicol. 1991 Jan;16(1):15–16. doi: 10.1016/0272-0590(91)90127-p. [DOI] [PubMed] [Google Scholar]
  27. Moghraby S. A., Abdullah M. A., Karrar O., Akiel A. S., Shawaf T. A., Majid Y. A. Lead concentrations in maternal and cord blood in women users of surma eye cosmetics. Ann Trop Paediatr. 1989 Mar;9(1):49–53. doi: 10.1080/02724936.1989.11748596. [DOI] [PubMed] [Google Scholar]
  28. Moser R., Oberley T. D., Daggett D. A., Friedman A. L., Johnson J. A., Siegel F. L. Effects of lead administration on developing rat kidney. I. Glutathione S-transferase isoenzymes. Toxicol Appl Pharmacol. 1995 Mar;131(1):85–93. doi: 10.1006/taap.1995.1050. [DOI] [PubMed] [Google Scholar]
  29. Oberley T. D., Friedman A. L., Moser R., Siegel F. L. Effects of lead administration on developing rat kidney. II. Functional, morphologic, and immunohistochemical studies. Toxicol Appl Pharmacol. 1995 Mar;131(1):94–107. doi: 10.1006/taap.1995.1051. [DOI] [PubMed] [Google Scholar]
  30. Ong C. N., Phoon W. O., Law H. Y., Tye C. Y., Lim H. H. Concentrations of lead in maternal blood, cord blood, and breast milk. Arch Dis Child. 1985 Aug;60(8):756–759. doi: 10.1136/adc.60.8.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Phuapradit W., Jetsawangsri T., Chaturachinda K., Noinongyao N. Maternal and umbilical cord blood lead levels in Ramathibodi Hospital, 1993. J Med Assoc Thai. 1994 Jul;77(7):368–372. [PubMed] [Google Scholar]
  32. Pirkle J. L., Brody D. J., Gunter E. W., Kramer R. A., Paschal D. C., Flegal K. M., Matte T. D. The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES) JAMA. 1994 Jul 27;272(4):284–291. [PubMed] [Google Scholar]
  33. Roels H., Hubermont G., Buchet J. P., Lauwerys R. Placental transfer of lead, mercury, cadmium, and carbon monoxide in women. III. Factors influencing the accumulation of heavy metals in the placenta and the relationship between metal concentration in the placenta and in maternal and cord blood. Environ Res. 1978 Jul;16(1-3):236–247. doi: 10.1016/0013-9351(78)90159-7. [DOI] [PubMed] [Google Scholar]
  34. Rothenberg S. J., Karchmer S., Schnaas L., Perroni E., Zea F., Fernández Alba J. Changes in serial blood lead levels during pregnancy. Environ Health Perspect. 1994 Oct;102(10):876–880. doi: 10.1289/ehp.94102876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Rothenberg S. J., Poblano A., Garza-Morales S. Prenatal and perinatal low level lead exposure alters brainstem auditory evoked responses in infants. Neurotoxicology. 1994 Fall;15(3):695–699. [PubMed] [Google Scholar]
  36. Saxena D. K., Singh C., Murthy R. C., Mathur N., Chandra S. V. Blood and placental lead levels in an Indian city: a preliminary report. Arch Environ Health. 1994 Mar-Apr;49(2):106–110. doi: 10.1080/00039896.1994.9937462. [DOI] [PubMed] [Google Scholar]
  37. Sierra E. M., Tiffany-Castiglioni E. Effects of low-level lead exposure on hypothalamic hormones and serum progesterone levels in pregnant guinea pigs. Toxicology. 1992;72(1):89–97. doi: 10.1016/0300-483x(92)90088-v. [DOI] [PubMed] [Google Scholar]
  38. Silbergeld E. K. Lead in bone: implications for toxicology during pregnancy and lactation. Environ Health Perspect. 1991 Feb;91:63–70. doi: 10.1289/ehp.919163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Snodgrass G. J., Ziderman D. A., Gulati V., Richards J. Letter: Cosmetic plumbism. Br Med J. 1973 Oct 27;4(5886):230–230. doi: 10.1136/bmj.4.5886.230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Soong Y. K., Tseng R., Liu C., Lin P. W. Lead, cadmium, arsenic, and mercury levels in maternal and fetal cord blood. J Formos Med Assoc. 1991 Jan;90(1):59–65. [PubMed] [Google Scholar]
  41. Sprinkle R. V. Leaded eye cosmetics: a cultural cause of elevated lead levels in children. J Fam Pract. 1995 Apr;40(4):358–362. [PubMed] [Google Scholar]
  42. Tabacova S., Balabaeva L. Environmental pollutants in relation to complications of pregnancy. Environ Health Perspect. 1993 Jul;101 (Suppl 2):27–31. doi: 10.1289/ehp.93101s227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Tang H. W., Liang Y. X., Hu X. H. Effects of low level lead exposure on behavior of young rats. Zhongguo Yao Li Xue Bao. 1994 Jul;15(4):316–319. [PubMed] [Google Scholar]
  44. Vyskocil A., Cizkova M., Tejnorova I. Effect of prenatal and postnatal exposure to lead on kidney function in male and female rats. J Appl Toxicol. 1995 Jul-Aug;15(4):327–328. doi: 10.1002/jat.2550150416. [DOI] [PubMed] [Google Scholar]
  45. al-Saleh I., Khalil M. A., Taylor A. Lead, erythrocyte protoporphyrin, and hematological parameters in normal maternal and umbilical cord blood from subjects of the Riyadh region, Saudi Arabia. Arch Environ Health. 1995 Jan-Feb;50(1):66–73. doi: 10.1080/00039896.1995.9955014. [DOI] [PubMed] [Google Scholar]

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