Abstract
OBJECTIVES: To examine an association between specific IgE to methyltetrahydrophthalic anhydride (MTHPA) and exposure time, atopic history, smoking habits, and total IgE concentrations. METHODS: A cross sectional survey was carried out on a population of 148 workers from two condenser plants using epoxy resin with MTHPA, an acid anhydride curing agent known to cause allergy. RESULTS: Using a Pharmacia CAP system with a MTHPA human serum albumin conjugate, specific IgE antibody was detected in serum from 97 (66%) out of the 148 workers exposed to MTHPA. Stepwise multiple linear regression analysis showed a striking relation between log concentrations of specific and total IgE (P < 0.0001). Furthermore, when the workers were divided into two groups according to a cut-off point (100 IU/ml) between low and high total IgE, current smoking was significantly (P = 0.025) associated with specific IgE production only in the group with low total IgE (< 100 IU/ml). CONCLUSIONS: Smoking is the most significant risk factor for raising specific IgE to MTHPA in the group with low total IgE concentrations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Botham P. A., Davies G. E., Teasdale E. L. Allergy to laboratory animals: a prospective study of its incidence and of the influence of atopy on its development. Br J Ind Med. 1987 Sep;44(9):627–632. doi: 10.1136/oem.44.9.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grammer L. C., Harris K. E., Sonenthal K. R., Ley C., Roach D. E. A cross-sectional survey of 46 employees exposed to trimellitic anhydride. Allergy Proc. 1992 May-Jun;13(3):139–142. doi: 10.2500/108854192778878755. [DOI] [PubMed] [Google Scholar]
- Liss G. M., Bernstein D., Genesove L., Roos J. O., Lim J. Assessment of risk factors for IgE-mediated sensitization to tetrachlorophthalic anhydride. J Allergy Clin Immunol. 1993 Aug;92(2):237–247. doi: 10.1016/0091-6749(93)90167-e. [DOI] [PubMed] [Google Scholar]
- Moller D. R., Gallagher J. S., Bernstein D. I., Wilcox T. G., Burroughs H. E., Bernstein I. L. Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride. J Allergy Clin Immunol. 1985 Jun;75(6):663–672. doi: 10.1016/0091-6749(85)90091-0. [DOI] [PubMed] [Google Scholar]
- Nielsen J., Welinder H., Horstmann V., Skerfving S. Allergy to methyltetrahydrophthalic anhydride in epoxy resin workers. Br J Ind Med. 1992 Nov;49(11):769–775. doi: 10.1136/oem.49.11.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nielsen J., Welinder H., Schütz A., Skerfving S. Specific serum antibodies against phthalic anhydride in occupationally exposed subjects. J Allergy Clin Immunol. 1988 Jul;82(1):126–133. doi: 10.1016/0091-6749(88)90062-0. [DOI] [PubMed] [Google Scholar]
- Venables K. M. Low molecular weight chemicals, hypersensitivity, and direct toxicity: the acid anhydrides. Br J Ind Med. 1989 Apr;46(4):222–232. doi: 10.1136/oem.46.4.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Venables K. M., Topping M. D., Howe W., Luczynska C. M., Hawkins R., Taylor A. J. Interaction of smoking and atopy in producing specific IgE antibody against a hapten protein conjugate. Br Med J (Clin Res Ed) 1985 Jan 19;290(6463):201–204. doi: 10.1136/bmj.290.6463.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Welinder H., Nielsen J., Gustavsson C., Bensryd I., Skerfving S. Specific antibodies to methyltetrahydrophthalic anhydride in exposed workers. Clin Exp Allergy. 1990 Nov;20(6):639–645. doi: 10.1111/j.1365-2222.1990.tb02702.x. [DOI] [PubMed] [Google Scholar]
- Zetterström O., Osterman K., Machado L., Johansson S. G. Another smoking hazard: raised serum IgE concentration and increased risk of occupational allergy. Br Med J (Clin Res Ed) 1981 Nov 7;283(6301):1215–1217. doi: 10.1136/bmj.283.6301.1215. [DOI] [PMC free article] [PubMed] [Google Scholar]