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PLOS One logoLink to PLOS One
. 2024 Jul 31;19(7):e0308239. doi: 10.1371/journal.pone.0308239

Sources of stress, coping strategies and associated factors among Vietnamese first-year medical students

Tan Nguyen 1, Christy Pu 1, Alexander Waits 1, Tuan D Tran 2, Yatan Pal Singh Balhara 3, Quynh Thi Vu Huynh 2, Song-Lih Huang 1,*
Editor: Diego A Forero4
PMCID: PMC11290621  PMID: 39089322

Abstract

Objectives

This study aims to examine the sources of stress among first-year medical students; the frequency of their coping strategies; the factors associated with specific stressors and specific coping strategies adopted by the participants.

Methods

We conducted a cross-sectional study with 409 first-year students at the University of Medicine and Pharmacy, Vietnam. The Vietnamese versions of the Higher Education Stress Inventory (V_HESI) and Brief Coping Orientation to Problems Experienced (V_Brief COPE) were validated and were used as measurement instruments for participants’ sources of stress and coping strategies frequencies. The survey comprised questions of socioeconomic status, stress-related issues, the six sources of stress (using the V_HESI), and the nine coping strategies (using the V_Brief COPE).

Results

Among the six sources of stress, “Worries about future competence/endurance” had the highest mean score (3.02±0.64), while “Mismatch in professional role expectations” had the lowest score (1.60±0.53). “Financial concerns” and “Academic workloads” were also significant sources of stress. Regarding coping strategies, Self-distraction was most frequently adopted by the participants (2.80 ± 0.68). Problem-solving (2.72±0.53) and seeking Social support (2.62±0.70) were also common adaptive strategies. Avoidance (1.87±0.55) and substance-use (1.27±0.55) were the least frequent strategies. Students who experienced acute stress event were more likely to have financial concerns compared to others. Substance use was positively associated with stressors from “Mismatch in professional role expectations”, “Non-supportive educational environment”, “Having physical issues” and “Having part-time job”. Self-blame was more frequent among students with “Worries about future competence/endurance”, “Financial concerns”, and “Academic workload”. Male student tended to adopt humor strategy (β = 0.19, p = 0.02), while less likely to utilize religious practices (β = -0.21, p = 0.01).

Conclusions

Two-thirds of the participants reported moderate to high levels of stress. “Worries about future competence/endurance” was the most concerned stressor, followed by “Academic workload”, and “Financial concerns”. The first-year medical students reported high frequency of utilization “Self-distraction”, “Problem-solving” and “Social support” when confronting stress. The findings may help inform the school management to better support students’ well-being.

Introduction

Stress and coping strategies have increasingly been studied, particularly in the population of medical students [15]. Studies in Vietnam show that the prevalence of experiencing stress among medical students are high, with more than 30% of the students perceived moderate to high level of stress [6, 7]. Being exposed to prolonged and high levels of stress may lead to negative consequences: cognitive and emotional burden, psychological distress, dropping out of school, low quality of life and decreased empathy with patients, which all may result in medical errors. These may influence the quality of health care service in the wide aspect [810]. Research has suggested that medical students experience stress from different sources, which could be from academic factors, psychosocial factors with emphasis on financial issues, teacher-student relationships, and high expectations from significant others and themselves [11, 12]. In addition, physical issues could also be an important stressor for medical students, which affects their academic performance and quality of life [13, 14]. Furthermore, in medical education settings, previous studies revealed that academic-related stressors may cause more distress than interpersonal, intrapersonal, or environmental stressors [15]. Early identification of these stressors could help tailor appropriate prevention and intervention programs to tackle the problematic psychological issues among this high-risk population [16, 17].

Coping strategies are specific efforts, cognitively and behaviorally, that help a person to tolerate, to minimize or to handle stressors. When confronting stressors, a person may end up with different types of coping strategies depending on the primary appraisal of the stressor as challenging or threatening, then the second appraisal of their available resources to cope with stressors [18]. There’re different ways to categorize coping strategies, consisting of problem-focused or emotion-focused, adaptive or maladaptive, approaching or avoiding [19, 20]. Adopting appropriate strategies would help students cope better and healthier with stressors, minimizing the negative consequences from stressors [2123]. Hence, it is essential to first understand what sources of stress that medical students are facing, then how they are coping with a variety of stressors. Furthermore, the link between potential associated factors with specific coping strategies would contribute to the understanding of coping model, which is important to figure out appropriate approaches to enhance the ability of students to deal effectively with stressors.

To date, few studies have directly examined the associations between specific sources of stress and types of coping strategies, particularly in the early phase of medical training. Our aims are to examine the sources of stress among first-year medical students, the frequencies of their coping strategies, and to explore the relationships between other factors with specific sources of stress and coping strategies employed by these students.

Methods

Study design

We conducted a cross-sectional study among the undergraduate students at the Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.

Participants

In this study, we invited all first-year students. Participants provided written informed consents before participating in the study. Students with informed consents and completed data were included in the study with no explicit exclusion criteria were employed. Amongst 420 students, 409 students participated in this study and completed the questionnaire.

Procedures

Participants filled in a self-administered survey two months after school admission. The survey was anonymous with no information to identify the participants. Data were collected from 12th November 2020 to 22nd December 2020, and have been accessed for data analysis since 24th December 2020. The principal investigator introduced the purpose of the study to all first-year students in an orientation at the beginning of the academic year. At the end of the orientation, the students sent back the consent forms to members of the research team. We sent a link of the survey to all students with written informed consent. The online survey was designed so all questions need to be completed before submission. The instructions were also given on how to fill in the online questionnaires, which consisted of four sections as mentioned below.

The survey included: (i) Demographic information (Age, Sex, Parental education status, Part-time job); (ii) Self-rated stress level, acute stress event, physical issues, psychological issues, Covid-19-related stress; (iii) Higher Education Stress Inventory (HESI) to assess the sources of stress; (iv) Brief Coping Orientation to Problems Experienced (Brief COPE) to assess the coping strategies. Level of stress was scored from 1 to 3 for low to high level, respectively. Mother and father educational levels were categorized into three levels (Elementary or lower, High school, and College or higher). Part-time job, acute stress event, physical stress, psychological stress, and Covid-19-related stress were binary variables with responses of yes or no.

Measurement tools

The HESI and Brief COPE went through five steps of validation including: (i) Forward translation, (ii) Backward translation, (iii) Assessment of content validity, (iv) Assessment of factor structure, and (v) Assessment of internal consistency. During the first step, the English instruments were translated from English to Vietnamese separately by two translators (the principal investigator and another team member who has the bachelors in both psychology and English. The second step was conducted by two Vietnamese who has lived in the United state for than 10 years and used English in their daily work. Any ambiguities or discrepancies in terms of context meaning or colloquialism were discussed and resolved through consensus among research team members. The results of the fourth and fifth steps are elaborated as following:

HESI

The original HESI was developed by Dahlin et al. in Sweden among medical students [24]. The strength of this scale is its ability to assess various sources of stress in different higher education settings. From 33 items from the original version, the Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) to get the revised scale with 20 items, categorized into six sources of stress. Cronbach’s alpha was 0.73 for the whole scale. CMIN/DF was 1.97, CFI was 0.901, and RMSEA < 0.06, which indicates adequate degree of model fitting. It can be considered that the above extracted results are feasible and acceptable for this study population. Respondents rate each statement of these 20 items on a 4-point Likert-type scale: 1 (Totally disagree) to 4 (Totally agree).

The six sources of stress included:

  1. Mismatch in professional role expectations (from four items “The training demands that I join in situations that I find unethical”; “The professional role presented in the training conflicts with my personal view”; “I feel that I am less well treated because of my ethnic background”; and “I feel that I am less well treated because of my sex”).

  2. Worries about future competence/endurance (from three items “I worry about long working hours and responsibilities in my future career”; “The insight I have had into my future profession has made me worries about the stressful workload”; “I am worried that I will not acquire all the knowledge needed for my future profession”).

  3. Financial concerns (from three items “As a student, my financial situation is a worry”, “I am worried about my future economy and my ability to repay students loans”; “I am worried about accommodation”).

  4. Academic workload (from three items “The literature is too difficult and extensive”; “The space of studies is too high”; “Studies control my life and I have little time for other activities”).

  5. Low identity of medical profession (from three items “I am satisfied with my choice of career”–reversed score; “I am proud of my future profession”–reversed score; “I am able to influence my studies”–reversed score).

  6. Non-supportive educational environment (from four items “Student union activities promote a sense of community and contribute to a better working environment for students”–reversed score; “The teachers often give feedback on students’ knowledge and skills”–reversed score; “I feel that the training is preparing me well for my future profession”–reversed score; “My fellow students support me”–reversed score)

The score of each source of stress was the average score of their related items, ranging from 1.0 to 4.0.

BRIEF COPE

Brief COPE was developed as a short version of the original 60-item COPE scale, by Carver et al (1989) [25], (Carver, 1997) [26]. Brief COPE is a 28-item measure, which is designed to assess the frequency of utilization of various coping strategies on a scale of 1 (I haven’t been doing this at all) to 4 (I’ve been doing this a lot). Our findings from EFA and CFA of the original Brief COPE revealed the revised 27-item scale with 9 categories of coping strategies. Cronbach’s alpha was 0.78. CMIN/DF is 1.99, CFI is greater than 0.9, RMSEA < 0.06, and SRMR < 0.08 which indicates a good degree of model fitting, and the above extracted results are feasible and acceptable for this study population.

The nine coping strategies included:

  1. Problem solving (from seven items “I’ve been taking action to try to make the situation better”; “I’ve been concentrating my efforts on doing something about the situation I’m in”; “I’ve been trying to come up with a strategy about what to do”; “I’ve been thinking hard about what steps to take”; “I’ve looking for something good in what is happening”; “I’ve been learning to live with it”; “I’ve been trying to see it in a different light, to make it seem more positive”).

  2. Social support (from four items “I’ve been getting help and advice from other people”; “I’ve been getting emotional support from others”; “I’ve been getting comfort and understanding from someone”; “I’ve been trying to get advice or help from other people about what to do”).

  3. Avoidance (from four items “I’ve been giving up the attempt to cope”; “I’ve been refusing to believe that it has happened”; “I’ve been giving up trying to deal with it”; “I’ve been saying to myself ‘this isn’t real’”).

  4. Substance use (from two items “I’ve been using alcohol or other drugs to make myself feel better”; “I’ve been using alcohol or other drugs to help me get through it”).

  5. Self-blame (from two items “I’ve been criticizing myself”; “I’ve been blaming myself for things that happened”).

  6. Religion (from two items “I’ve been praying or meditating”; “I’ve been trying to find comfort in my religion or spiritual beliefs”)

  7. Humor (from two items “I’ve been making fun of the situation”; “I’ve been making jokes about it”).

  8. Venting (from two items “I’ve been saying things to let my unpleasant feeling escape”; “I’ve been expressing my negative feelings”).

  9. Self-distraction (from two items “I’ve been doing something to think about it less, such as going to movies, watching TV, reading, daydreaming, sleeping or shopping”; “I’ve been turning to work or other activities to take my mind off things”).

The score of each coping strategy was the average score of their related items, ranging from 1.0 to 4.0.

Analytical approach

We used RStudio [27] and SPSS 26 for data analyses. Descriptive statistics (mean, standard deviation, and percentage) were used for calculating the frequencies and proportions of demographic variables, sources of stress, and coping strategies. To assess the factors associated with sources of stress and coping strategies, multiple linear regressions, with forced entry regressions, were estimated. For each source of stress as dependent variable, the independent variables included all sociodemographic factors: sex, age, parental educational levels, part-time job, level of perceived stress, and other stress-related variables (acute stress event, physical stress, psychological stress, Covid-19-related stress). Similarly for each coping strategy as dependent variable, we run different regression models that included different sources of stress and all the above sociodemographic and stress-related factors as independent variables.

This study was approved by the IRB of National Yang Ming Chiao Tung University and University of Medicine and Pharmacy, and guidelines for research with human subjects were followed.

Results

Sociodemographic of participants

Table 1 shows the characteristics of the study population. Among the 409 participants, the mean age was 18±0.38 years. Approximately 40% of participants were female. Most of the participants’ parents finished their high school or higher education. More than 20% of students reported experiencing either physical issues or psychological issues, while less than 10% had stress due to Covid-19. Among the participants, there were 231 students (57%) reported a moderate level of stress, and 36 students (8.9%) had a high level of stress (Table 1).

Table 1. Characteristics of the study participants.

N = 409 students
Age
Mean (SD) 18.1 (0.38)
Sex
Female (N, %) 151 (36.9%)
Male (N,%) 258 (63.1%)
Father education
Primary school or lower (N, %) 11 (2.7%)
High school (N, %) 108 (26.4%)
College or higher (N, %) 290 (70.9%)
Mother education
Primary school or lower (N, %) 21 (5.1%)
High school (N, %) 161 (39.4%)
College or higher (N, %) 227 (55.5%)
Part-time job
Yes (N, %) 32 (7.8%)
No (N, %) 377 (92.2%)
Acute stress
Yes (N, %) 119 (29.1%)
No (N%) 290 (70.9%)
Physical stress
Yes (N, %) 98 (24.0%)
No (N, %) 311 (76.0%)
Psychosocial stress
Yes (N, %) 93 (22.7%)
No (N, %) 316 (77.3%)
Covid-19—related stress
Yes (N, %) 39 (9.5%)
No (N, %) 370 (90.5%)
Stress level
Low (N, %) 142 (34.7%)
Moderate (N, %) 231 (56.5%)
High (N, %) 36 (8.8%)

The sources of stress and the coping strategies adopted by the participants

Fig 1 illustrates the sources of stress among the study participants, using the Vietnamese version of HESI scale. The HESI subscale scores are listed in descending order from the participants. “Worries about future competence/endurance” had the highest mean score among 409 participants (3.02±0.64), while “Mismatch in professional role expectations” had the lowest score (1.60±0.53). “Financial concerns” and “Academic workloads” were also significant sources of stress among first-year students in this study, with the mean scores of 2.65 and 1.86, respectively. The other stressors with less concerns were “Low identity of medical profession” (mean score: 1.87) and “Non-supportive educational environment” (mean score: 1.80) (Fig 1).

Fig 1. Sources of stress among 409 students, using the revised 20-item HESI scale.

Fig 1

The coping strategies scores of the participants are shown in Fig 2. Regarding coping strategies employed by the study population, Self-distraction was the most frequently reported among these 409 students (2.80 ± 0.68). However, Problem-solving and seeking Social support were predominant the other less adaptive strategies, with the scores were 2.72 (0.53) and 2.62 (0.70), respectively. Self-blame also had a high score (2.52±0.74), i.e., it appears quite frequently among the participants. Avoidance (1.87±0.55) and substance-use (1.27±0.55) were the least frequent strategies adopted to cope with stress (Fig 2).

Fig 2. Coping strategies scores of 409 students, using the revised 27-item brief COPE scale.

Fig 2

Factors associated with sources of stress and coping strategies adopted by the participants

Table 2 shows the factors that are associated with specific source of stress among the participants. Students who reported high perceived stress level are more likely to get stressed due to “Mismatch in professional role expectations”, “Worries about future competence/endurance”, and “Non-supportive educational environment”. Students experiencing acute stress event were more likely to have financial concerns compared to other students (β = 0.20). On the other hand, “Low identity of medical profession” was found associated with female students and students who had part-time jobs. Female students are also more likely to have “Worries about future competence/endurance”.

Table 2. Factors associated with the six sources of stress.

Factors Estimates p-value
Mismatch in professional role expectations
Low perceived stress level -0.32 0.003
Worries about future competence/endurance
Being male student -0.23 <0.001
Low perceived stress level -0.28 0.033
Financial concerns
Experiencing acute stress event 0.20 0.027
Low identity of medical profession
Being male student -0.14 0.007
Having part-time job 0.28 0.005
Non-supportive educational environment
Low perceived stress level -0.28 0.004
Moderate perceived stress level -0.19 0.030

For each source of stress, we ran a separate regression. The regression models were adjusted for: sex, age, parental educational levels, part-time job, level of perceived stress, acute stress event, physical stress, psychological stress, Covid-19-related stress.

Only factors with statistical significance were listed in Table 2.

Table 3 illustrates a variety of associated factors with coping strategies utilized by the participants. Students with “Low identity of medical profession” were less likely to have orientations to solve the problem (β = -0.11) or to seek social support (β = -0.25). Meanwhile, students with stressors due to “Mismatch in professional role expectations” tend to have both adaptive and maladaptive strategies: Humor (β = 0.25), Religion (β = 0.3), Avoidance (β = 0.22), and Substance use (β = 0.25). Substance use was also found positively associated with stressors from “Non-supportive educational environment”, “Having physical issues” and “Having part-time jobs”. On the other hand, Self-blame was reported higher frequency among students with “Worries about future competence/endurance” (β = 0.14), “Financial concerns” (β = 0.17), “Academic workload” (β = 0.18). Male student tent to adopt humor strategy (β = 0.19, p = 0.020), while less likely to utilize religious practices (β = -0.21, p = 0.013). Meanwhile, students experiencing psychological issues tend to not use “Self-distraction” as a coping orientation to their problems (β = -0.23, p = 0.013).

Table 3. Factors associated with the nine coping strategies.

Factors Estimates p-value
Problem solving
Low identity of medical profession -0.11 0.029
Social support
Low identity of medical profession -0.25 <0.001
Avoidance
Mismatch in professional role expectations 0.22 <0.001
Substance use
Mismatch in professional role expectations 0.25 <0.001
Non-supportive educational environment 0.15 0.011
Having physical issues 0.15 0.033
Having part-time job 0.20 0.048
Self-blame
Worries about future competence/ endurance 0.14 0.013
Financial concerns 0.17 <0.001
Academic workload 0.18 0.003
Religion
Mismatch in professional role expectations 0.30 <0.001
Being male student -0.21 0.013
Humor
Mismatch in professional role expectations 0.25 <0.001
Being male student 0.19 0.020
Self-distraction
Having psychological issues -0.23 0.013

For each coping strategy, we ran a separate regression. The regression models were adjusted for: sources of stress, sex, age, parental educational levels, part-time job, level of perceived stress, acute stress event, physical stress, psychological stress, Covid-19-related stress.

Only factors with statistical significance were listed in Table 3.

Discussions

This study examined the sources of stress and the coping strategies adopted by first-year medical students at University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. Analyses were conducted to investigate whether there are associations between specific sources of stress and specific coping strategies. We found that specific sources of stressors were linked to specific strategies when students confront stress. Either “Worries about future competence/endurance”, “Financial concerns” or “Academic workload” was found positively associated with Self-blame. On the other hand, when students had “Low identity of medical profession”, they were less likely to solve the problem or to seek social support (emotional or instrumental support). While “Mismatch in professional role expectations” was positively associated with the likelihood of adoption different coping strategies, namely Humor, Religion (Religious practice), Avoidance, and Substance use strategies; the source of stress named “Non-supportive educational environment” was only significantly associated with Substance use among the participants. Moreover, students with physical issues were more likely to use substances to deal with stress compared to those reported no stress due to physical issues. These associations were found independent of demographic factors, psychosocial factors and stress-related factors.

The results reveal that two-thirds of the participants rated their stress levels were moderate to high level after admission two months. This is comparable to other studies from Vietnam and other medical school in other countries [28, 29]. A cross-sectional study conducted among 411 first-year students at the University of Medicine of Pharmacy of Ho Chi Minh City and Can Tho in 2020 showed almost 50% of students have problems with stress [28]. Another cross-sectional study in 2003 among 686 students at the Faculty of Medicine, at Ramathibodi Hospital in Thailand found that 61.4% of the medical students reported different perceived levels of stress. However, only 2.4% of students rated their stress level as high in that study, whereas our finding showed 8.9% of the participants had high level of stress. Also in the above study, when rating the sources of stress from a questionnaire, the most prevalent sources of stress of these 686 medical students were from academic performance, including Test/exam (99% of the students), Falling behind in reading schedule (~97% of the students), Getting poor marks (~93% of the students), or Heavy workload (85.2% of the students). “Feeling of incompetence” was reported from 78.4%, while poor motivation to learn met in 48% of the students [29]. The sources of stress reported in our studies were measured by the revised 20-items HESI scale, which showed that Worries about future incompetence/endurance was the highest ranked stressor of the participants. “Academic workload” came as the second significant source of stress, followed by “Financial concerns”. One remarkable observation was that the scores of the remaining three sources of stress were much lower than the first ranked three stressors above. Previous studies also suggested that psychosomatic discomfort, e.g., menstrual disturbance or polycystic ovary syndrome in female medical students, had negative effects on students’ academic performance and their quality of life [13, 14]. This suggests that medical undergraduate students face a variety of stressors, which are not just limited to academic burden, but encompass their self-expectations and motivations to practice medical profession in the future. However, in this study we utilized the HESI instrument that could not examine the physiological stressors of medical students and the associations of these stressors with coping strategies adopted by medical students.

Mismatch in professional role expectations with their inner conflicts to educational activities, served as other sources of stress. Pursuing medical practice requires students to understand patients’ suffering and be willing to provide necessary treatment with professionalism and empathy. Accordingly, training activities would build up professional roles with specific expectations, including but not limited to being authentic, ethical, and respectful. Without the necessary supportive system, students would feel frustrated and stressed, particularly in their first year entering medical education. In our study, “Non-supportive educational environment” includes both the school environment and teacher-student relationships. Previous studies focus on students’ experiences of homesick, difficulties in adapting new environments, as well as lacks of contact with family [30]; or competitive, cold and impersonal attitudes [31]. Since HESI was not designed specifically for medical education settings, we do not measure other sources of stress from medical training: facing illness or death of patients, parental wish for you to study medicine [15].

The role of gender when investigating stressors in medical students has long been studied, with inconsistent findings. In our study, female students were more likely to get stress due to their worries of future competence/endurance and their low identity of medical profession, but not other sources of stress. This finding was aligned with other studies as non-male gender has been identify as risk factor of medical students’ distress [32], particular stressor due to academic workload [33, 34]. On the other hand, study of Yogesh et al of 100 first-year medical students showed that stress levels due to academic and interpersonal issues were lower in female compared to their male counterpart [11]. Another study of Sadiq et al revealed higher levels of all stressors among female students, but no significant correlations between gender and sources of stress was found [15]. Furthermore, our findings showed that students experiencing acute stress event tend to be stressed due to financial concerns, while students with part-time jobs were more likely to report stress of “Low identity of medical profession”. We have not found any evidence of demographic and social factors associated with stressors among medical students in the available research. Understanding the association of these socioeconomic factors and different sources of stress would help school administrators analyze and figure out appropriate approaches to support these students. Further studies may need to explore more these relationships.

Regarding coping strategies, Self-distraction was the most frequently used among 409 participants. However, active coping strategies (Problem-solving, seeking for Social support, Venting) were also popular in this study population. This was aligned with findings of other studies on coping strategies of medical students [3537]. On the other hand, Humor and Religion (Religious practice) were reported with lower frequency. Religious practicing was one of the most adopted coping strategies in some countries [38, 39], but not in our study population. Positive religious practice has been proved to have positive effect on students’ resilience and their mental health [40, 41]. Among the maladaptive coping strategies, Self-blame had a relatively high score, whereas Substance-use and Avoidance were found not frequently adopted by the participants. These are positive findings among the first-year students since previous studies conducted in the United Kingdom and in Nepal found “Substance use” as a very common coping strategies among medical students [4244]. However, under-reporting cannot be ruled out. Since substance-use was regarded as moral issue in Vietnam society, students might not be open about it despite the anonymity and confidentiality nature of our surveys.

Associations between different factors and coping strategies were observed. Overall, the strength of associations was low to moderate, yet in the expected directions. This study found that the levels of perceived stress was not linked to any specific coping strategies, which was discrepant with the previous findings that high level of stress would increase the use of maladaptive coping strategies including self-blame, substance use, denial, wishful thinking, behavioral disengagement [45, 46]. Male students were more likely to adopt humor strategy than their female counterpart, while less likely to have religious practice. This was similar to the results of a study conducted in a sample of 94 medical students in their third year about the use of humor strategy [47]. This also added new insights into the previous studies about coping strategies’ differences among male and female medical students. Though the common findings were that female students tent to adopt emotional and instrumental support, venting and self-distraction [47, 48], we did not find the significant associations between students’ gender with these coping strategies. Provided that these associations between stressors and coping strategies have not been studied in the field of medical training, our findings were novel and would shed the light on approaches to enhance students’ coping strategies to deal with different sources of stress.

The study has some limitations, including the nature of cross-sectional study could not draw any causal relationship between the sources of stressors and coping strategies adopted by the participants. Also, when using the Brief COPE to measure the frequency of coping strategies adopted by medical students, the items did not specify the sources of stress that result in such coping strategies. Hence, we could not imply the high frequency of any coping strategy due to any specific source of stressors. However, the strength of this study was the participation of 97% of first-year students in a school, enhancing the representative of the first-year medical students at Faculty of Medicine, at University of Medicine and Pharmacy. Furthermore, the instruments used went through the five-step validation among first-year medical students, ensuring the validity and reliability of the scales.

Conclusions

Medical students were exposed to a variety of stressors since their first year of training, and the results showed that two-thirds of students reporting moderate to high level of stress. “Worries about future competence/endurance” was the most concerned stressor, followed by “Academic workload”, and “Financial concerns”. The participants reported high frequency of utilization “Self-distraction”, “Problem-solving” and seeking “Social support” when dealing with stress. The findings revealed significant associated factors of sources of stress and coping strategies adopted by first-year medical students. These observations may help inform the school administrators and leaders of the status of stressors and coping as well as suggest appropriate approaches to support their students’ well-being.

Supporting information

S1 Checklist. STROBE statement—checklist of items that should be included in reports of observational studies.

(DOCX)

pone.0308239.s001.docx (47.1KB, docx)

Acknowledgments

We would like to thank our participants for their willingness to complete the surveys. We also would like to express our gratitude to the school leaders for being supportive for us to accomplish this study.

Data Availability

The datasets generated and/or analyzed during the current study are not publicly available due to the data protection policy of University of Medicine and Pharmacy, but are available from the corresponding author on reasonable request. Data requests may be sent to the Medical Ethics Board of the University of Medicine and Pharmacy (hoidongdaoducdhyd@ump.edu.vn).

Funding Statement

The author(s) received no specific funding for this work.

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Decision Letter 0

Diego A Forero

24 Jul 2023

PONE-D-23-15195Sources of stress, coping strategies and associated factors among Vietnamese first-year medical studentsPLOS ONE

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Reviewer #1: The authors provided an extensive characterization of stressors and the coping strategies among medical students. The manuscript is well written however, please find my suggestions below. I will appreciate if the authors could address these issues.

1. I understand the sources of external stressors which cause difficulty of quality of life index for medical students. However, it's equally important to indicate the physiological stressors as well. Two recent articles demonstrated how a physiological abnormality like PMS/PMDD may lead to low academic and social life of medical students leading to additional amount of internal stressors. It will be beneficial for our reader and the policy makers at least to be aware of this too. Here are the two links:

DOI: 10.7759/cureus.40141

DOI: 10.3389/fmed.2022.821908

2. Results: Overall comments: The results are expressed in table format which is fine for me however, please use graphical format for better presentation and use the table as supplemental as required. My intention is not to make you work more but to make your manuscript more readable.

Table 1:Characteristics of the study participants. This table can be easily shown with a bar diagram/scatter plot or by any visual graphical way. Therefore, represent the data of table 1 with a graph and attach the table as supplemental if necessary.

Table 2: Sources of stress among 409 students, using the revised 20-item HESI scale. This table has the mean and SD values. Therefore, please use a graph rather than the table to represent the data.

Table 3: Coping strategies scores of 409 students, using the revised 27-item Brief COPE scale. Please do the same for this table as well.

Table 4: Factors associated with the six sources of stress. This table may stay as it is.

Table 5: Factors associated with the nine coping strategies. As per this table some of the factors such as social support has p value of <0.001 whereas the other has >0.001. Therefore, use the data of this table to convert to a graphical chart(may be a bar diagram) and then indicate which bars are significant by adding * on top that bar. I hope this makes sense. This is the traditional way of representing data. Off course, you can add the table as supplemental if required.

Discussion: The discussion is well written however please find my suggestions below.

Generally, the discussion starts with a paragraph stating the problem, hypothesis. However, the authors directly started discussion the result. This disrupts the flow and readability. Please modify.

The discussion section should include references of systematic review and meta-analysis of medical student and stressor. You may consider using these recent references

DOI: 10.7759/cureus.40141

DOI: 10.3389/fmed.2022.821908

Reviewer #2: I could not agree less that the study is germane and would benefit Vietnamese readers. However, several incorrect claims were made in the manuscript. This manuscript needs to be worked on since the journal does not offer copyediting services. Please refer to the PDF file for comments and recommendations.

**********

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Reviewer #2: No

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Attachment

Submitted filename: PONE-D-23-15195_reviewed.pdf

pone.0308239.s002.pdf (914.5KB, pdf)
PLoS One. 2024 Jul 31;19(7):e0308239. doi: 10.1371/journal.pone.0308239.r002

Author response to Decision Letter 0


19 Feb 2024

Reviewers’ comments

Dear Reviewers,

We are grateful for your time and effort reviewing our manuscript. Your comments and suggestions directed us to improve our analysis and writing. Kindly refer to the point-by-point revisions we conducted in response to your comments.

Reviewer 1

Dear reviewer, we are very grateful for your time dedicated to reading our manuscript. Your comments provided multiple insights and helped us to improve our writing. We tried our best to carefully address your comments. Kindly refer to the details below.

1. I understand the sources of external stressors which cause difficulty of quality of life index for medical students. However, it's equally important to indicate the physiological stressors as well. Two recent articles demonstrated how a physiological abnormality like PMS/PMDD may lead to low academic and social life of medical students leading to additional amount of internal stressors. It will be beneficial for our reader and the policy makers at least to be aware of this too. Here are the two links:

DOI: 10.7759/cureus.40141

DOI: 10.3389/fmed.2022.821908

We added the statement and the discussion of the effects of physical issues or physiological stressors on medical students’ academic performance and quality of life, using the references from your recommendation (Line 55-57, Line 300-302, and Line 305-307 in the revised manuscript) in the Introduction section and in the Discussion section, as following:

- In Introduction section:

“In addition, physical issues could also be an important stressor for medical students, which affects their academic performance and quality of life.”

- In Discussion section:

“Previous studies also suggested that psychosomatic discomfort, e.g., menstrual disturbance or polycystic ovary syndrome in female medical students, had negative effects on students’ academic performance and their quality of life.”

“However, in this study we utilized the HESI instrument that could not examine the physiological stressors of medical students and the associations of these stressors with coping strategies adopted by medical students.”

2. Results: Overall comments: The results are expressed in table format which is fine for me however, please use graphical format for better presentation and use the table as supplemental as required. My intention is not to make you work more but to make your manuscript more readable.

Table 1: Characteristics of the study participants. This table can be easily shown with a bar diagram/scatter plot or by any visual graphical way. Therefore, represent the data of table 1 with a graph and attach the table as supplemental if necessary.

Table 2: Sources of stress among 409 students, using the revised 20-item HESI scale. This table has the mean and SD values. Therefore, please use a graph rather than the table to represent the data.

Table 3: Coping strategies scores of 409 students, using the revised 27-item Brief COPE scale. Please do the same for this table as well.

Table 4: Factors associated with the six sources of stress. This table may stay as it is.

Table 5: Factors associated with the nine coping strategies. As per this table some of the factors such as social support has p value of <0.001 whereas the other has >0.001. Therefore, use the data of this table to convert to a graphical chart(may be a bar diagram) and then indicate which bars are significant by adding * on top that bar. I hope this makes sense. This is the traditional way of representing data. Off course, you can add the table as supplemental if required.

Thank you for your thorough suggestions and instructions on the use of figures in our manuscript. We have added Figure 1 and Figure 2 to replace Table 2 and Table 3 in the old manuscript. For Table 1, however, we’d like to keep the table format to show detailed information about demographic factors of the participants. Similarly, for Table 5, we’d like to keep as it is to have the consistency of data presentation from the factors associated with stressors and with coping strategies.

3. Discussion: The discussion is well written however please find my suggestions below.

Generally, the discussion starts with a paragraph stating the problem, hypothesis. However, the authors directly started discussion the result. This disrupts the flow and readability. Please modify.

We added a paragraph in the Discussion section to state the objectives and our approaches (Line 264-279 in the revised manuscript), as following:

“This study examined the sources of stress and the coping strategies adopted by first-year medical students at University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. Analyses were conducted to investigate whether there are associations between specific sources of stress and specific coping strategies. We found that specific sources of stressors were linked to specific strategies when students confront stress. Either “Worries about future competence/endurance”, “Financial concerns” or “Academic workload” was found positively associated with Self-blame. On the other hand, when students had “Low identity of medical profession”, they were less likely to seek social support (emotional or instrumental support). While “Mismatch in professional role expectations” was positively associated with the likelihood of adoption different coping strategies, namely Humor, Religion (Religious practice), Avoidance, and Substance use strategies; the source of stress named “Non-supportive educational environment” was only significantly associated with Substance use among the participants. Moreover, students with physical issues were more likely to use substances to deal with stress compared to those reported no stress due to physical issues. These associations were found independent of demographic factors, psychosocial factors and stress-related factors.”

The discussion section should include references of systematic review and meta-analysis of medical student and stressor. You may consider using these recent references

DOI: 10.7759/cureus.40141

DOI: 10.3389/fmed.2022.821908

We added two sentences in the Discussion section to mention the effects of physiological issues on medical students’ academic performance and quality of life as you suggested, and why we did not measure the physiological stressors of medical students (Line 300-302, and Line 305-307 in the revised manuscript), as following:

“Previous studies also suggested that psychosomatic discomfort, e.g., menstrual disturbance or polycystic ovary syndrome in female medical students, had negative effects on students’ academic performance and their quality of life.”

“However, in this study we utilized the HESI instrument that could not examine the physiological stressors of medical students and the associations of these stressors with coping strategies adopted by medical students.”

Reviewer 2

Dear reviewer, we are very grateful for your time dedicated to reading our manuscript. Your comments provided multiple insights and helped us to improve our writing. We tried our best to carefully address your comments. Kindly refer to the details that we’ve revised based on your comments and suggestions from the PDF file.

In summary, there’re some points that we’ve revised to elaborate more details:

- The objectives of this study include examining the associations between specific sources of stress and specific coping strategies. Although there have been multiple studies on the associations between demographic factors and psychosocial factors with sources of stress or with coping strategies. To the best of our knowledge, the associations between these two main outcomes have not been investigated. We revised the statement to be clearer (Line 79-81 and Line 226-229 in the revised manuscript), as following:

“To date, few studies have directly examined the associations between specific sources of stress and types of coping strategies.”

- We added a brief description of the university and the medical program as you suggested (Line 76-79 in the revised manuscript), as following:

“The University of Medicine and Pharmacy (UMP) in Ho Chi Minh City has adopted a reformed medical program, which is outcome-based medical education. This reformed program was considered with higher demands and more stressful than the old program, particularly for first-year students who have just entered medical training.”

- We elaborated our approaches to collect data (Line 93 and Line 99-105 in the revised manuscript), as following:

“Amongst 420 students, 409 students participated in this study and completed the questionnaire.”

“The principal investigator introduced the purpose of the study to all first-year students in an orientation at the beginning of the academic year. At the end of the orientation, the students sent back the consent forms to members of the research team. We sent a link of the survey to all students with written informed consent. The online survey was designed so all questions need to be completed before submission. The instructions were also given on how to fill in the online questionnaires,”

- We moved the variable definitions from the Analytical approach section to Procedure section as you suggested, (Line 110-114 in the revised manuscript), as following:

“Level of stress was scored from 1 to 3 for low to high level, respectively. Mother and father educational levels were categorized into three levels (Elementary or lower, High school, and College or higher). Part-time job, acute stress event, physical stress, psychological stress, and Covid-19-related stress were binary variables with responses of yes or no.”

- We moved the description of instruments’ validation steps from the Analytical approach section to Measurement tools section as you suggested. We also add elaboration on how the items of the questionnaires were modified throughout five-step validation process (Line 116-125 in the revised manuscript), as following:

“The HESI and Brief COPE went through five steps of validation including: (i) Forward translation, (ii) Backward translation, (iii) Assessment of content validity, (iv) Assessment of factor structure, and (v) Assessment of internal consistency. During the first step, the English instruments were translated from English to Vietnamese separately by two translators (the principal investigator and another team member who has the bachelors in both psychology and English. The second step was conducted by two Vietnamese who has lived in the United state for than 10 years and used English in their daily work. Any ambiguities or discrepancies in terms of context meaning or colloquialism were discussed and resolved through consensus among research team members. The results of the fourth and fifth steps are elaborated as following:”

- We added the statement that the survey was designed to have all the items completed before submission, so we did not have missing data from our dataset (Line 103-104 in the revised manuscript), as following:

“The online survey was designed so all questions need to be completed before submission.”

- We revised Table 1 for the wrong numbers in the table. This was because we mistakenly keyed in from the outputs of statistical software. Thank you very much for your revisions.

- We added references, elaborated the references, and revised the writing in the Discussion part regarding the prevalence of stress among medical students (Line 282-294 in the revised manuscript), as following:

“A cross-sectional study conducted among 411 first-year students at the University of Medicine of Pharmacy of Ho Chi Minh City and Can Tho in 2020 showed almost 50% of students have problems with stress. Another cross-sectional study in 2003 among 686 students at the Faculty of Medicine, at Ramathibodi Hospital in Thailand found that 61.4% of the medical students reported different perceived levels of stress. However, only 2.4% of students rated their stress level as high in that study, whereas our finding showed 8.9% of the participants had high level of stress. Also in the above study, when rating the sources of stress from a questionnaire, the most prevalent sources of stress of these 686 medical students were from academic performance, including Test/exam (99% of the students), Falling behind in reading schedule (~97% of the students), Getting poor marks (~93% of the students), or Heavy workload (85.2% of the students). “Feeling of incompetence” was reported from 78.4%, while poor motivation to learn met in 48% of the students”

- We added references, and revised the writing in the Discussion part regarding then religious practice of medical students (Line 343-345 in the revised manuscript), as following:

“Religious practicing was one of the most adopted coping strategies in some countries (32,33), but not in our study population. Positive religious practice has been proved to have positive effect on students’ resilience and their mental health.”

- Besides the above, we’ve revised the typo, rewrote the manuscript, added details in the revised manuscript, along with your comments and suggestions, as you may find:

o Line 272-276 in the revised manuscript, as following:

“While “Mismatch in professional role expectations” was positively associated with the likelihood of adoption different coping strategies, namely Humor, Religion (Religious practice), Avoidance, and Substance use strategies; the source of stress named “Non-supportive educational environment” was only significantly associated with Substance use among the participants.”

o Line 372-374 in the revised manuscript, as following:

“Also, when using the Brief COPE to measure the frequency of coping strategies adopted by medical students, the items did not specify the sources of stress that result in such coping strategies.”

o Line 375-380 in the revised manuscript, as following:

“However, the strength of this study was the participation of 97% of first-year students in a school, enhancing the representative of the first-year medical students at Faculty of Medicine, at University of Medicine and Pharmacy. Furthermore, the instruments used went through the five-step validation among first-year medical students, ensuring the validity and reliability of the scales.”

o Line 382-384 in the revised manuscript), as following:

“Medical students were exposed to a variety of stressors since their first year of training, and the results showed that two-thirds of students reporting moderate to high level of stress.”

- We’ve checked the Reference to make sure it follows the format of the journal, which is Vancouver style.

Attachment

Submitted filename: PlosOne_Response to Reviewers and Editor_11.09.docx

pone.0308239.s003.docx (365.1KB, docx)

Decision Letter 1

Diego A Forero

19 Mar 2024

PONE-D-23-15195R1Sources of stress, coping strategies and associated factors among Vietnamese first-year medical studentsPLOS ONE

Dear Dr. Huang,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

I agree with the reviewer about the need for a minor revision.

Please submit your revised manuscript by May 03 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

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If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Diego A. Forero, MD; PhD

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #3: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #3: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #3: No

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #3: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Thank you for your work. I really enjoyed reading the updated version of the manuscript. I have one very minor request. Please improve the quality of the figure 1 and 2. I think there are ways to improve the image quality. The written part of the figures are not clearly visible.

Reviewer #3: Thank you, for to opportunity to review this paper about the source of stress and coping modalities amongst first year Medical Students in Vietnam. Utilizing validated measurement instruments, the study identifies key stressors and coping mechanisms prevalent among this demographic. he findings underscore the significance of addressing stress management strategies to support the well-being of medical students.

The authors mentioned that the university has adopted a new reform medical program and that is a more stressful for the students.

P 14

‘’76 The University of Medicine and Pharmacy (UMP) in Ho Chi Minh City has adopted a

77 reformed medical program, which is outcome-based medical education. This reformed

78 program was considered with higher demands and more stressful than the old program,

79 particularly for first-year students who have just entered medical training.’’

Please describe the characteristics of the program, why do you consider it more stressful, what is the difference with the previous program? Do you have any evidence for this? And why the first-year students are affected, did the change was in the middle of university year? Otherwise the current program is the only thing they no directly.

The study was carried in 2020, the students were online or onsite? As it was during the pandemic.

The references are not in Vancouver style as required by the Journal.

Reference 15 missing the Journal and reference 19 either is missing the Journal or it is not a paper and should be quoted differently.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #3: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2024 Jul 31;19(7):e0308239. doi: 10.1371/journal.pone.0308239.r004

Author response to Decision Letter 1


25 Mar 2024

Reviewer 1

1. I have one very minor request. Please improve the quality of the figure 1 and 2. I think there are ways to improve the image quality. The written part of the figures are not clearly visible.

We have already uploaded the new versions of Figure 1 and Figure 2, using the tool provided in the instruction.

Reviewer 2

1. The authors mentioned that the university has adopted a new reform medical program and that is a more stressful for the students.

P 14

‘’The University of Medicine and Pharmacy (UMP) in Ho Chi Minh City has adopted a reformed medical program, which is outcome-based medical education. This reformed program was considered with higher demands and more stressful than the old program, particularly for first-year students who have just entered medical training.’’

Please describe the characteristics of the program, why do you consider it more stressful, what is the difference with the previous program? Do you have any evidence for this? And why the first-year students are affected, did the change was in the middle of university year? Otherwise the current program is the only thing they no directly.

We have elaborated more details of the reformed program and explain why we perceived it more stressful for medical students, particularly for first-year students. Please refer to Line 77 – Line 86 of the revised manuscript: (We also added the reference of the reformed program of the university from 2016 – reference 18)

This reformed program was considered with higher demands than the old program. Students were introduced to family- and community-based medicine in the early phase of education. New components were integrated in the curriculum, namely Professionalism, Interprofessional education, Scholarly project, and Practice of medicine with the purpose of training students on basic clinical skills in the first two years. A student-centered approach was adopted in all teaching and learning settings 1. The self-directed learning requires students to be more proactive, which is stressful for students who are not familiar with this new education method, particularly the first-year students who have just entered medical training.

2. The study was carried out in 2020, the students were online or onsite? As it was during the pandemic.

During the time we collected these surveys, the students still studied at the university (onsite). The study was conducted before the surge in 2021, when we had a strict quarantine policy.

3. The references are not in Vancouver style as required by the Journal.

Reference 15 missing the Journal and reference 19 either is missing the Journal or it is not a paper and should be quoted differently.

We have revised the references following the Vancouver style and added the Journal of reference 15 and reference 19, which has become reference 20.

Attachment

Submitted filename: PlosOne_Response to Reviewers and Editor_25.03.docx

pone.0308239.s004.docx (22.6KB, docx)

Decision Letter 2

Diego A Forero

16 May 2024

PONE-D-23-15195R2Sources of stress, coping strategies and associated factors among Vietnamese first-year medical studentsPLOS ONE

Dear Dr. Huang,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

I agree with the reviewer about the need for a further revision of the manuscript.

Please submit your revised manuscript by Jun 30 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Diego A. Forero, MD; PhD

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #4: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #4: No

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #4: No

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #4: No

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #4: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #4: Thank you for the opportunity to review this paper on stress and coping strategies among medical students in Vietnam. The authors hypothesize that the newly introduced medical education program may contribute to increased stress among medical students compared to the previous program and conducted a survey to investigate the psychosocial backgrounds of medical students. While the results provide some evidence for the need for psychological support for medical students, there are significant concerns that remain for publication as a research paper. In particular, there are serious methodological errors that require substantial revisions before resubmission. Below are the points of concern:

The authors discuss the analysis results of this study, suggesting that the newly introduced outcome-based medical education program may be a contributing factor to stress among medical students. However, as there is no comparison with data from before the new program was introduced, the discussion appears speculative. Please remove statements that may lead to misinterpretation. Additionally, please consider citing studies on stress levels among medical students in other countries and discuss whether stress levels among medical students in Vietnam are particularly high.

In this study, multivariate analysis was conducted using multiple regression analysis. However, the authors' description does not ensure reproducibility. Moreover, only partial results are presented in the tables. Please clearly specify the dependent variables and the independent variables included for each test. It is also not mentioned whether forced entry or stepwise methods were used for independent variable selection.

As per my understanding, it seems that the authors conducted 15 repeated multiple regression analyses, with sociodemographic characteristics (age, sex, father education, mother education, part-time-job, physical stress, psychosocial stress, COVID-19 related stress, stress level) as independent variables, and a total of 15 items from HESI and Brief COPE as dependent variables. This testing method appears to have significant flaws. Since each item of HESI and Brief COPE uses a Likert-type scoring method, they are categorical variables rather than continuous variables, making their use as dependent variables in multiple regression analysis methodologically incorrect. It would be more appropriate to conduct multinomial logistic regression analyses for each item of HESI and Brief COPE to calculate odds ratios. Additionally, correction for multiple testing should be applied. Please conduct a fundamental review of the methodology.

The authors mention the high participation rate of the study participants (97%) as a strength of the study. However, we are concerned that this high participation rate may reflect a distortion of participants' voluntary consent. Please clarify the relationship between the authors and the students. Would you say there is any possibility at all that vulnerable students were coerced into participating in the study? Explain the ethical concerns.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #4: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2024 Jul 31;19(7):e0308239. doi: 10.1371/journal.pone.0308239.r006

Author response to Decision Letter 2


30 Jun 2024

Dear Reviewers,

We are grateful for your time and effort reviewing our manuscript. Your comments and suggestions directed us to improve our analysis and writing. Kindly refer to the point-by-point revisions we conducted in response to your comments.

Reviewer 4:

The authors discuss the analysis results of this study, suggesting that the newly introduced outcome-based medical education program may be a contributing factor to stress among medical students. However, as there is no comparison with data from before the new program was introduced, the discussion appears speculative. Please remove statements that may lead to misinterpretation. Additionally, please consider citing studies on stress levels among medical students in other countries and discuss whether stress levels among medical students in Vietnam are particularly high.

- Thank you for your opinion and recommendations. We have removed the description of the transformed outcome-based medical education program of the university. We also added the statement and references of the situation of stress among medical students in Vietnam (Line 48 – 50 in the revised manuscript) in the Introduction section as following:

“Studies in Vietnam show that the prevalence of experiencing stress among medical students are high, with more than 30% of the students perceived moderate to high level of stress.”

- We added a statement to elaborate the rationale to conduct this study among first year students (Line 80 in the revised manuscript) in the Introduction section as following:

“To date, few studies have directly examined the associations between specific sources of stress and types of coping strategies, particularly in the early phase of medical training.”

In this study, multivariate analysis was conducted using multiple regression analysis. However, the authors' description does not ensure reproducibility. Moreover, only partial results are presented in the tables. Please clearly specify the dependent variables and the independent variables included for each test. It is also not mentioned whether forced entry or stepwise methods were used for independent variable selection.

Thank you for your question to clarify this part. We provided more details about data analysis approaches as your recommendations (Line 203 – 209 in the revised manuscript) in the Analytical approach as following:

“To assess the factors associated with sources of stress and coping strategies, multiple linear regressions, with forced entry regressions, were estimated. For each source of stress as dependent variable, the independent variables included all sociodemographic factors: sex, age, parental educational levels, part-time job, level of perceived stress, and other stress-related variables (acute stress event, physical stress, psychological stress, Covid-19-related stress). Similarly for each coping strategy as dependent variable, we run different regression models that included different sources of stress and all the above sociodemographic and stress-related factors as independent variables.”

As per my understanding, it seems that the authors conducted 15 repeated multiple regression analyses, with sociodemographic characteristics (age, sex, father education, mother education, part-time-job, physical stress, psychosocial stress, COVID-19 related stress, stress level) as independent variables, and a total of 15 items from HESI and Brief COPE as dependent variables. This testing method appears to have significant flaws. Since each item of HESI and Brief COPE uses a Likert-type scoring method, they are categorical variables rather than continuous variables, making their use as dependent variables in multiple regression analysis methodologically incorrect. It would be more appropriate to conduct multinomial logistic regression analyses for each item of HESI and Brief COPE to calculate odds ratios. Additionally, correction for multiple testing should be applied. Please conduct a fundamental review of the methodology.

- Thank you for your recommendation. We have reviewed the analysis and revised the analysis, basically on the types of the independent variables (changed the type of Father educational level, Mother educational level, and Perceived stress levels into Categorical variables instead of Continuous variables as in the previous analysis). We have revised the results in Table 2 and Table 3 in the revised manuscripts, as following:

Table 2: Factors associated with the six sources of stress

Factors Estimates p-value

Mismatch in professional role expectations

Low perceived stress level -0.32 0.003

Worries about future competence/endurance

Being male student -0.23 <0.001

Low perceived stress level -0.28 0.033

Financial concerns

Experiencing acute stress event 0.20 0.027

Low identity of medical profession

Being male student -0.14 0.007

Having part-time job 0.28 0.005

Non-supportive educational environment

Low perceived stress level -0.28 0.004

Moderate perceived stress level -0.19 0.030

For each source of stress, we ran a separate regression. The regression models were adjusted for: sex, age, parental educational levels, part-time job, level of perceived stress, acute stress event, physical stress, psychological stress, Covid-19-related stress.

Only factors with statistical significance were listed in Table 2.

Table 3: Factors associated with the nine coping strategies

Factors Estimates p-value

Problem solving

Low identity of medical profession -0.11 0.029

Social support

Low identity of medical profession -0.25 <0.001

Avoidance

Mismatch in professional role expectations 0.22 <0.001

Substance use

Mismatch in professional role expectations 0.25 <0.001

Non-supportive educational environment 0.15 0.011

Having physical issues 0.15 0.033

Having part-time job 0.20 0.048

Self-blame

Worries about future competence/ endurance 0.14 0.013

Financial concerns 0.17 <0.001

Academic workload 0.18 0.003

Religion

Mismatch in professional role expectations 0.30 <0.001

Being male student -0.21 0.013

Humor

Mismatch in professional role expectations 0.25 <0.001

Being male student 0.19 0.020

Self-distraction

Having psychological issues -0.23 0.013

For each coping strategy, we ran a separate regression. The regression models were adjusted for: sources of stress, sex, age, parental educational levels, part-time job, level of perceived stress, acute stress event, physical stress, psychological stress, Covid-19-related stress.

Only factors with statistical significance were listed in Table 3.

- We added the elaboration of the findings in Table 2 and Table 3 (Line 245 – 251, Line 258 – 259 and Line 267 – 270 in the revised manuscript) in the Results section as following:

“Students who reported high perceived stress level are more likely to get stressed due to “Mismatch in professional role expectations”, “Worries about future competence/endurance”, and “Non-supportive educational environment”. Students experiencing acute stress event were more likely to have financial concerns compared to other students (β=0.20). On the other hand, “Low identity of medical profession” was found associated with female students and students who had part-time jobs. Female students are also more likely to have “Worries about future competence/endurance”.”

“Table 3 illustrates a variety of associated factors with coping strategies utilized by the participants. Students with “Low identity of medical profession” were less likely to have orientations to solve the problem (β=-0.11) or to seek social support (β=-0.25).”

“Male student tent to adopt humor strategy (β=0.19, p=0.020), while less likely to utilize religious practices (β=-0.21, p=0.013). Meanwhile, students experiencing psychological issues tend to not use “Self-distraction” as a coping orientation to their problems (β= -0.23, p=0.013).”

- Regarding the statistical characteristics of the dependent variables (six sources of stress and nine coping strategies), please refer to the following elaboration:

Although items in the two tools Higher Education Stress Inventory (HESI) and Brief Coping Orientation to Problems Experienced (Brief COPE), were scored using the Likert-type scales, they are typically treated as scores rather than categories, and analyzed based on the summation of scores from clusters of items rather than on the score of an individual item. For HESI, the higher scores indicate higher levels of perceived stressor (1-3). Similarly, for Brief COPE, the higher scores indicate the more frequently the coping orientations were adopted (4-6). In this study, we analyzed the data as previous studies. We conducted analysis to examine the level of perceived stressors, the frequency of adopting coping orientations, and the association (if any) between the perceived stressors and the coping orientations.

Following your recommendations, we’ve performed the binominal logistic regression, in which each factor of HESI and each factor of Brief COPE were treated as binary variable. To be more specific, for HESI, each factor has two categories as Yes (I agree I have this stressor) and No (I disagree I have this stressor). For Brief COPE, each factor has two categories as Yes (I usually adopt this coping orientation to experienced problems) and No (I do not usually adopt this coping orientation to experienced problems).

We have run the Binominal Logistic Regressions and please refer to the findings in Appendix enclosed to this Response, but we have opted to present the data in the same manner as previous studies (1-6).

The authors mention the high participation rate of the study participants (97%) as a strength of the study. However, we are concerned that this high participation rate may reflect a distortion of participants' voluntary consent. Please clarify the relationship between the authors and the students. Would you say there is any possibility at all that vulnerable students were coerced into participating in the study? Explain the ethical concerns.

This study is among the three studies of a project to provide the Transforming Stress Program to all first-year students. This Transforming Stress Program was introduced to all first-year students in their orientation session at the beginning of the school year. It was introduced as an extra-curricular activity, and there was no other measure taken to enhance participation. The fact that it was endorsed by the school administration may help explain the high participation rate. Before they took the training, we invited them to fill out the survey to have the baseline information about their current stress mindset, stressors, and coping strategies on a voluntary basis. The process involves nothing of a coercive nature.

The Principal Investigator was an alumnus of the University and has no relationship with the first-year students. This study had been approved by the IRB of the University. We introduced the study to all students and got their agreement to join in this study by the written Informed Consent Forms.

1. Saxena SK, Mani RN, Dwivedi AK, Ryali V, Timothy A. Association of educational stress with depression, anxiety, and substance use among medical and engineering undergraduates in India. Industrial psychiatry journal. 2019;28(2):160-9.

2. Pacheco JPG, Hoffmann MS, Braun LE, Medeiros IP, Casarotto D, Hauck S, et al. Translation, cultural adaptation, and validation of the Brazilian Portuguese version of the Higher Education Stress Inventory (HESI-Br). Trends in psychiatry and psychotherapy. 2023;45:e20210300.

3. Shim E-J, Jeon HJ, Kim H, Lee K-M, Jung D, Noh H-L, et al. Measuring stress in medical education: validation of the Korean version of the higher education stress inventory with medical students. BMC Medical Education. 2016;16.

4. Matsumoto S, Yamaoka K, Nguyen HDT, Nguyen DT, Nagai M, Tanuma J, et al. Validation of the Brief Coping Orientation to Problem Experienced (Brief COPE) inventory in people living with HIV/AIDS in Vietnam. Global health & medicine. 2020;2(6):374-83.

5. García FE, Barraza-Peña CG, Wlodarczyk A, Alvear-Carrasco M, Reyes-Reyes A. Psychometric properties of the Brief-COPE for the evaluation of coping strategies in the Chilean population. Psicologia: Reflexão e Crítica. 2018;31(1):22.

6. Babakhani M, Aghabarary M, Norouzinia R. Perceived stress and coping strategies after unsuccessful cardiopulmonary resuscitation among pre-hospital emergency technicians: A multicenter cross-sectional study. Heliyon. 2024;10(10):e31418.

Attachment

Submitted filename: Ressponses to Reviewers_27.06.docx

pone.0308239.s005.docx (32.3KB, docx)

Decision Letter 3

Diego A Forero

11 Jul 2024

Sources of stress, coping strategies and associated factors among Vietnamese first-year medical students

PONE-D-23-15195R3

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Acceptance letter

Diego A Forero

22 Jul 2024

PONE-D-23-15195R3

PLOS ONE

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Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Checklist. STROBE statement—checklist of items that should be included in reports of observational studies.

    (DOCX)

    pone.0308239.s001.docx (47.1KB, docx)
    Attachment

    Submitted filename: PONE-D-23-15195_reviewed.pdf

    pone.0308239.s002.pdf (914.5KB, pdf)
    Attachment

    Submitted filename: PlosOne_Response to Reviewers and Editor_11.09.docx

    pone.0308239.s003.docx (365.1KB, docx)
    Attachment

    Submitted filename: PlosOne_Response to Reviewers and Editor_25.03.docx

    pone.0308239.s004.docx (22.6KB, docx)
    Attachment

    Submitted filename: Ressponses to Reviewers_27.06.docx

    pone.0308239.s005.docx (32.3KB, docx)

    Data Availability Statement

    The datasets generated and/or analyzed during the current study are not publicly available due to the data protection policy of University of Medicine and Pharmacy, but are available from the corresponding author on reasonable request. Data requests may be sent to the Medical Ethics Board of the University of Medicine and Pharmacy (hoidongdaoducdhyd@ump.edu.vn).


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