Abstract
An epidemic of cytomegalovirus disease (CMV) occurred in 38 percent of 34 renal transplant recipients during an 18-month period. A characteristic clinical pattern was noted: 40 days following transplantation, daily fevers recurred for periods of four to six weeks. This fever in conjunction with a diffuse interstitial pneumonitis and impaired hepatic and renal function constituted a diagnostic tetrad. Of all the laboratory techniques, throat and urine cultures were the most consistent in confirming the diagnosis.
Analysis of the epidemic implicated the communal hemodialysis unit as the source of exposure to the virus. CMV was not seen in the first 86 patients who received transplants in the program, but with increasing use of hemodialysis, the percentage of patients with positive serologic reaction for CMV increased dramatically.
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- Dorfman L. J. Cytomegalovirus encephalitis in adults. Neurology. 1973 Feb;23(2):136–144. doi: 10.1212/wnl.23.2.136. [DOI] [PubMed] [Google Scholar]
- Fine R. N., Grushkin C. M., Anand S., Lieberman E., Wright H. T., Jr Cytomegalovirus in children. Am J Dis Child. 1970 Sep;120(3):197–202. doi: 10.1001/archpedi.1970.02100080081004. [DOI] [PubMed] [Google Scholar]
- HILL R. B., Jr, ROWLANDS D. T., Jr, RIFKIND D. INFECTIOUS PULMONARY DISEASE IN PATIENTS RECEIVING IMMUNOSUPPRESSIVE THERAPY FOR ORGAN TRANSPLANTATION. N Engl J Med. 1964 Nov 12;271:1021–1027. doi: 10.1056/NEJM196411122712001. [DOI] [PubMed] [Google Scholar]
- Kanich R. E., Craighead J. E. Cytomegalovirus infection and cytomegalic inclusion disease in renal homotransplant recipients. Am J Med. 1966 Jun;40(6):874–882. doi: 10.1016/0002-9343(66)90202-6. [DOI] [PubMed] [Google Scholar]
- MEDEARIS D. N., Jr OBSERVATIONS CONCERNING HUMAN CYTOMEGALOVIRUS INFECTION AND DISEASE. Bull Johns Hopkins Hosp. 1964 Mar;114:181–211. [PubMed] [Google Scholar]
- Reed W., Lucas Z. J., Kempson R., Cohn R. Renal transplantation in patients with Australia antigenemia. Transplant Proc. 1971 Mar;3(1):343–346. [PubMed] [Google Scholar]
- Sobel J. D., Fanaroff A. A. Cytomegalovirus infection with raised alkaline phosphatase. Lancet. 1968 Sep 21;2(7569):689–689. doi: 10.1016/s0140-6736(68)92551-8. [DOI] [PubMed] [Google Scholar]
- Wolf P. L., Williams D., Coplon N., Coulson A. S. Low aspartate transaminase activity in serum of patients undergoing chronic hemodialysis. Clin Chem. 1972 Jun;18(6):567–568. [PubMed] [Google Scholar]