In the Original Research article entitled Hemodiafiltration versus Hemodialysis in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis that appeared in the June 2024 issue of Kidney Medicine (Guimarães et al, volume 6, issue 6, 100829), 2 tables were omitted from the final publication. The tables are included below.
In the Results section, under Study Selection and Baseline Characteristics, Table 1 should have been cited as follows: A total of 4,134 patients with end-stage kidney disease were included in this meta-analysis, with 2,078 (50.1%) undergoing HDF and 2,065 (49.8%) treated with HD. The study characteristics are presented in Table 1.
Table 1.
Characteristics of Included Studies
| Study | Design | Convection Volume, L/Sessiona | Blood Flow, HDF/HD, mL/mina | Control Group | Follow-up, moa | Patient, HDF/HD | Age (y)a, HDF/HD | Female, (%), HDF/HD | AV fistula, (%), HDF/HD | DM, (%), HDF/HD | CVD, (%), HDF/HD |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Grooteman 2012 (CONTRAST)15 | RCT | 20.7 | 332/312 | Low-flux HD | 36 | 358/356 | 64.2/64.0 | 40/35 | 78/81 | 26/22 | 42/46 |
| Ok 2013 (TURKISH OL-HDF)16 | RCT | 17.2 | 294/294 | High-flux HD | 22.7 | 391/391 | 56.4/56.5 | 40.4/41.9 | 95.7/95.4 | 36.3/33.2 | 27.2/25.7 |
| Maduell 2013 (ESHOL)8 | RCT | 22.9-23.9 | 389/380 | High-flux HD | 22.9 | 456/450 | 64.5/66.3 | 30.5/35.8 | 89.3/82.7 | 22.8/27.1 | NA |
| Morena 2017 (FRENCHIE)17 | RCT | 21 | 349.5/334.9 | High-flux HD | 19.6 | 190/191 | 76.3/76.1 | 40/39.7 | 68.9/68 | 39.3/38.4 | 52.6/51 |
| Blankestijn 2023 (CONVINCE)9 | RCT | 23 | 369/367 | High-flux HD | 30 | 683/677 | 62.5/62.3 | 36.2/38 | 81.7/82.3 | 33.7/37.1 | 43.3/46.7 |
Abbreviations: AV, arteriovenous; CVD, cardiovascular disease; DM, diabetes; HD, hemodialysis; HDF, hemodiafiltration; HTN, hypertension; L, liters; RCT, randomized controlled trial.
Mean or median.
In the Results section, under Quality Assessment, Table 2 should have been cited as follows: The individual appraisal of each randomized controlled trial included in the meta-analysis is summarized in the Supplementary Material. The studies included were found to have a risk of bias classified as either some concerns or high. A summary of the findings and certainty of evidence is shown in Table 2.
Table 2.
Summary of Findings and Certainty of Evidence for Selected Outcomes (GRADE)
| Certainty Assessment |
Summary of Findings |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Participants (Studies) Follow-up | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Overall Certainty of Evidence | Study Event Rates (%) |
Relative Effect (95% CI) | Anticipated Absolute Effects |
|||
| With Hemodialyisis | With Hemodifiltration | Risk With Hemodialyisis | Risk Difference With Hemodifiltration | |||||||||
| All-cause mortality | 4,143 (5 RCTs) | Serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁◯ Moderate | 516/2,065 (25.0%) | 422/2,078 (20.3%) | RR 0.81 (0.73-0.91) | 250 per 1.000 | 47 fewer per 1.000 (from 67 fewer to 22 fewer) |
| CV mortality | 3,762 (4 RCTs) | Serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁◯ Moderate | 182/1,874 (9.7%) | 137/1,888 (7.3%) | RR 0.75 (0.61-0.92) | 97 per 1.000 | 24 fewer per 1.000 (from 38 fewer to 8 fewer) |
| Infection-related mortality | 3,048 (3 RCTs) | Serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁◯ Moderate | 89/1,518 (5.9%) | 62/1,530 (4.1%) | RR 0.69 (0.50-0.95) | 59 per 1.000 | 18 fewer per 1.000 (from 29 fewer to 3 fewer) |
| Kidney transplant | 4,143 (5 RCTs) | Serious | Not serious | Not serious | Serious | None | ⨁⨁◯◯ Low | 233/2,064 (11.3%) | 268/2,079 (12.9%) | RR 1.14 (0.97-1.34) | 113 per 1.000 | 16 more per 1.000 (from 3 fewer to 38 more) |
Abbreviation: +, degree of certainty; RR, risk ratio.
Footnotes
Address for Correspondence: Maria Gabriela Guimarães, Nephrology, Hospital Ana Nery, Salvador, Brazil. (e-mail: gabrielaguimar@hotmail.com)