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. 1974 Sep;121(3):173–178.

Superinfections of the Lung

An Evaluation for Serial Transtracheal Aspirations

E Jack Benner 1,2, Jurg P Munzinger 1,2, Richard Chan 1,2
PMCID: PMC1129562  PMID: 4153490

Abstract

A prospective evaluation of cephaloridine, cephalothin, and lincomycin was conducted in 85 patients with pneumonia. None of the 50 with previous history of allergic sensitivity to penicillin had an allergic reaction. All cases of pure “pneumococcal pneumonia” were cured, regardless of the drug. Eight patients with polymicrobial pneumonia were cured by the cephalosporins, while lincomycin was ineffective in four patients who had polymicrobial pneumonia.

Although expectorated sputum and exudates from the nasopharyngeal and oropharyngeal areas contained large concentrations of Staphylococcus aureus and various Gram-negative bacillary species during and at the end of therapy, serial cultures of transtracheal aspirate and the clinical course failed to confirm “superinfection” of the lung.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartlett J. G., Rosenblatt J. E., Finegold S. M. Percutaneous transtracheal aspiration in the diagnosis of anaerobic pulmonary infection. Ann Intern Med. 1973 Oct;79(4):535–540. doi: 10.7326/0003-4819-79-4-535. [DOI] [PubMed] [Google Scholar]
  2. GREEN G. M., KASS E. H. FACTORS INFLUENCING THE CLEARANCE OF BACTERIA BY THE LUNG. J Clin Invest. 1964 Apr;43:769–776. doi: 10.1172/JCI104961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HILDING A. C. TIME-LAPSE RELATION TO CHANGES IN THE RESPIRATORY EPITHELIUM AFTER MINIMAL TRAUMA. Acta Otolaryngol. 1964 Mar-Apr;57:352–367. doi: 10.3109/00016486409137095. [DOI] [PubMed] [Google Scholar]
  4. Hoeprich P. D. Etiologic diagnosis of lower respiratory tract infections. Calif Med. 1970 Feb;112(2):1–8. [PMC free article] [PubMed] [Google Scholar]
  5. Johanson W. G., Pierce A. K., Sanford J. P. Changing pharyngeal bacterial flora of hospitalized patients. Emergence of gram-negative bacilli. N Engl J Med. 1969 Nov 20;281(21):1137–1140. doi: 10.1056/NEJM196911202812101. [DOI] [PubMed] [Google Scholar]
  6. Kalinske R. W., Parker R. H., Brandt D., Hoeprich P. D. Diagnostic usefulness and safety of transtracheal aspiration. N Engl J Med. 1967 Mar 16;276(11):604–608. doi: 10.1056/NEJM196703162761103. [DOI] [PubMed] [Google Scholar]
  7. Kunin C. M., Tupasi T., Craig W. A. Use of antibiotics. A brief exposition of the problem and some tentative solutions. Ann Intern Med. 1973 Oct;79(4):555–560. doi: 10.7326/0003-4819-79-4-555. [DOI] [PubMed] [Google Scholar]
  8. LOURIA D. B., KAMINSKI T. The effects of four antimicrobial drug regimens on sputum superinfection in hospitalized patients. Am Rev Respir Dis. 1962 May;85:649–665. doi: 10.1164/arrd.1962.85.5.649. [DOI] [PubMed] [Google Scholar]
  9. Monroe P. W., Muchmore H. G., Felton F. G., Pirtle J. K. Quantitation of microorganisms in sputum. Appl Microbiol. 1969 Aug;18(2):214–220. doi: 10.1128/am.18.2.214-220.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SHULMAN J. A., PHILLIPS L. A., PETERSDORF R. G. ERRORS AND HAZARDS IN THE DIAGNOSIS AND TREATMENT OF BACTERIAL PNEUMONIAS. Ann Intern Med. 1965 Jan;62:41–58. doi: 10.7326/0003-4819-62-1-41. [DOI] [PubMed] [Google Scholar]
  11. SMITH J. R., HOWLAND W. S. Endotracheal tube as a source of infection. J Am Med Assoc. 1959 Jan 24;169(4):343–345. doi: 10.1001/jama.1959.73000210001009. [DOI] [PubMed] [Google Scholar]
  12. Spencer C. D., Beaty H. N. Complications of transtracheal aspiration. N Engl J Med. 1972 Feb 10;286(6):304–306. doi: 10.1056/NEJM197202102860607. [DOI] [PubMed] [Google Scholar]

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