Skip to main content
PMC home page
The Western Journal of Medicine logoLink to The Western Journal of Medicine
. 1975 Mar;122(3):194–198.

Erythroblastemia

Mehdi Tavassoli 1
PMCID: PMC1129678  PMID: 1096474

Abstract

The significance of erythroblastemia must be considered in the context of the clinical setting in which it is found. Interpretation should take into account the number and spectrum of maturity of the nucleated red cells; the presence or absence of reticulocytosis and other red cell abnormalities (for example, poikilocytosis); the presence or absence of anemia; the presence or absence of circulating immature granulocytes or bizarre platelets and the presence or absence of the spleen. Circulating nucleated red cells indicate intravascular hemopoiesis or disruption of marrow structure or the inability of the bone marrow's screen mechanism to prevent their passage into circulation. In the latter situations, it usually indicates an unfavorable prognosis.

Full text

PDF
194

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbrecht P. H., Greene J. A., Jr Serum erythropoietin after renal homotransplantation. Ann Intern Med. 1966 Nov;65(5):908–921. doi: 10.7326/0003-4819-65-5-908. [DOI] [PubMed] [Google Scholar]
  2. BESSIS M., BRICKA M. Aspect dynamique des cellules du sang; son étude par la microcinématographie en contraste de phase. Rev Hematol. 1952;7(3):407–435. [PubMed] [Google Scholar]
  3. Clifford G. O. The clinical significance of leukoerythroblastic anemia. Med Clin North Am. 1966 May;50(3):779–790. doi: 10.1016/s0025-7125(16)33177-7. [DOI] [PubMed] [Google Scholar]
  4. DESAUSSURE C. NORMOBLASTEMIA. J S C Med Assoc. 1964 Oct;60:316–319. [PubMed] [Google Scholar]
  5. Denny W. F., Flanigan W. J., Zukoski C. F., 3rd Serial erythropoietin studies in patients undergoing renal homotransplantation. J Lab Clin Med. 1966 Mar;67(3):386–397. [PubMed] [Google Scholar]
  6. FRUMIN A. M., MENDELL T. H., MINTZ S. S., NOVACK P., FAULK A. T. Nucleated red blood cells in congestive heart failure. Circulation. 1959 Sep;20:367–370. doi: 10.1161/01.cir.20.3.367. [DOI] [PubMed] [Google Scholar]
  7. GARDNER F. H., PRINGLE J. C., Jr Androgens and erythropoiesis. II. Treatment of myeloid metaplasia. N Engl J Med. 1961 Jan 19;264:103–111. doi: 10.1056/NEJM196101192640301. [DOI] [PubMed] [Google Scholar]
  8. GROSS S., MARYMONT J. H., Jr EXTRAMEDULLARY HEMATOPOIESIS AND METASTATIC CANCER IN THE SPLEEN. Am J Clin Pathol. 1963 Aug;40:194–196. doi: 10.1093/ajcp/40.2.194. [DOI] [PubMed] [Google Scholar]
  9. Gardner F. H., Nathan D. G. Androgens and erythropoiesis. 3. Further evaluation of testosterone treatment of myelofibrosis. N Engl J Med. 1966 Feb 24;274(8):420–426. doi: 10.1056/NEJM196602242740802. [DOI] [PubMed] [Google Scholar]
  10. HILTS S. V., SHAW C. C. Leukemoid blood reactions. N Engl J Med. 1953 Sep 10;249(11):434–438. doi: 10.1056/NEJM195309102491102. [DOI] [PubMed] [Google Scholar]
  11. Hudson G., Yoffey J. M. The passage of lymphocytes through the sinusoidal endothelium of guinea-pig bone arrow. Proc R Soc Lond B Biol Sci. 1966 Oct 11;165(1001):486–496. doi: 10.1098/rspb.1966.0079. [DOI] [PubMed] [Google Scholar]
  12. KASPER C. K., WHISSELL D. Y., WALLERSTEIN R. O. CLINICAL ASPECTS OF IRON DEFICIENCY. JAMA. 1965 Feb 1;191:359–363. doi: 10.1001/jama.1965.03080050005001. [DOI] [PubMed] [Google Scholar]
  13. Merenstein G. B., Blackmon L. R., Kushner J. Nucleated red-cells in the newborn. Lancet. 1970 Jun 13;1(7659):1293–1294. doi: 10.1016/s0140-6736(70)91773-3. [DOI] [PubMed] [Google Scholar]
  14. Nies B. A., Cohn R., Schrier S. L. Erythremia after renal transplantation. N Engl J Med. 1965 Oct 7;273(15):785–788. doi: 10.1056/NEJM196510072731503. [DOI] [PubMed] [Google Scholar]
  15. RETIEF F. P. LEUCO-ERYTHROBLASTOSIS IN THE ADULT. Lancet. 1964 Mar 21;1(7334):639–642. doi: 10.1016/s0140-6736(64)91456-4. [DOI] [PubMed] [Google Scholar]
  16. SCHWARTZ S. O., STANSBURY F. Significance of nucleated red blood cells in peripheral blood; analysis of 1,496 cases. J Am Med Assoc. 1954 Apr 17;154(16):1339–1340. doi: 10.1001/jama.1954.02940500019007. [DOI] [PubMed] [Google Scholar]
  17. STARZL T. E., MARCHIORO T. L., RIFKIND D., HOLMES J. H., ROWLANDS D. T., Jr, WADDELL W. R. FACTORS IN SUCCESSFUL RENAL TRANSPLANTATION. Surgery. 1964 Jul;56:296–318. [PMC free article] [PubMed] [Google Scholar]
  18. Song S. H., Groom A. C. Immature and abnormal erythrocytes present in the normal, healthy spleen. Scand J Haematol. 1971;8(6):487–493. doi: 10.1111/j.1600-0609.1971.tb00903.x. [DOI] [PubMed] [Google Scholar]
  19. TWOMEY J. J., LEAVELL B. S. LEUKEMOID REACTIONS TO TUBERCULOSIS. Arch Intern Med. 1965 Jul;116:21–28. doi: 10.1001/archinte.1965.03870010023005. [DOI] [PubMed] [Google Scholar]
  20. Tavassoli M. Arterial structure of bone marrow in the rabbit with special reference to the thin-walled arteries. Acta Anat (Basel) 1974;90(4):608–616. doi: 10.1159/000144366. [DOI] [PubMed] [Google Scholar]
  21. Tavassoli M. Bone marrow erythroclasia: the function of perisinal macrophages relative to the uptake of erythroid cells. J Reticuloendothel Soc. 1974 Feb;15(2):163–169. [PubMed] [Google Scholar]
  22. Tavassoli M., Crosby W. H. Fate of the nucleus of the marrow erythroblast. Science. 1973 Mar 2;179(4076):912–913. doi: 10.1126/science.179.4076.912. [DOI] [PubMed] [Google Scholar]
  23. Tavassoli M., Weiss L. An electron microscopic study of spleen in myelofibrosis with myeloid metaplasia. Blood. 1973 Aug;42(2):267–279. [PubMed] [Google Scholar]
  24. WEST C. D., LEY A. B., PEARSON O. H. Myelophthisic anemia in cancer of the breast. Am J Med. 1955 Jun;18(6):923–931. doi: 10.1016/0002-9343(55)90173-x. [DOI] [PubMed] [Google Scholar]
  25. Ward H. P., Holman J. The association of nucleated red cells in the peripheral smear with hypoxemia. Ann Intern Med. 1967 Dec;67(6):1190–1194. doi: 10.7326/0003-4819-67-6-1190. [DOI] [PubMed] [Google Scholar]
  26. Weiss L., Tavassoli M. Anatomical hazards to the passage of erythrocytes through the spleen. Semin Hematol. 1970 Oct;7(4):372–380. [PubMed] [Google Scholar]
  27. Weiss L. The structure of bone marrow. Functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia: an electron microscopic study. J Morphol. 1965 Nov;117(3):467–537. doi: 10.1002/jmor.1051170308. [DOI] [PubMed] [Google Scholar]
  28. Weiss L. Transmural cellular passage in vascular sinuses of rat bone marrow. Blood. 1970 Aug;36(2):189–208. [PubMed] [Google Scholar]
  29. Westerman M. P., Jenkins J. L., Dekker A., Kreutner A., Jr, Fisher B. Significance of erythrocytosis and increased erythropoietin secretion after renal transplantation. Lancet. 1967 Oct 7;2(7519):755–757. doi: 10.1016/s0140-6736(67)91951-4. [DOI] [PubMed] [Google Scholar]
  30. YOFFEY J. M. A note on the thick-walled and thin-walled arteries of bone marrow. J Anat. 1962 Oct;96:425–425. [PMC free article] [PubMed] [Google Scholar]
  31. ZAMBONI L., PEASE D. C. The vascular bed of red bone marrow. J Ultrastruct Res. 1961 Mar;5:65–85. doi: 10.1016/s0022-5320(61)80006-3. [DOI] [PubMed] [Google Scholar]

Articles from Western Journal of Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES