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. 1975 May;122(5):371–376.

Isoniazid-Associated Hepatitis

Serum Enzyme Determinations and Histologic Features

James E Lewis 1, Paul Mello 1, C Michael Knauer 1
PMCID: PMC1129751  PMID: 1130028

Abstract

A prospective study of 208 patients treated for up to 12 months with isoniazid (INH®) for tuberculosis prophylaxis was made. Levels of serum glutamic oxaloacetic acid transaminase (SGOT) became elevated in 20 percent of the adults followed and in 30 percent predominantly nonspecific symptoms developed, in 11 percent simultaneously with SGOT elevation; SGOT levels became elevated in two of 33 children and 1 was symptomatic. Mild SGOT elevations in asymptomatic adults were self-limited; however, a small percentage of symptomatic adults showed prolonged SGOT elevation for months after INH was completed. Results of liver biopsy studies in the early stages of SGOT elevation generally showed portal and periportal lymphocytic infiltrations with lesser numbers of plasma cells, neutrophils and eosinophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERTE S. J., DIMASE J. D., CHRISTIANSON C. S. ISONIAZID, PARA-AMINOSALICYLIC ACID, AND STREPTOMYCIN INTOLERANCE IN 1,744 PATIENTS. AN ANALYSIS OF REACTIONS TO SINGLE DRUGS AND DRUG GROUPS PLUS DATA ON MULTIPLE REACTIONS, TYPE AND TIME OF REACTIONS, AND DESENSITIZATION. Am Rev Respir Dis. 1964 Oct;90:598–606. doi: 10.1164/arrd.1964.90.4.598. [DOI] [PubMed] [Google Scholar]
  2. Bailey W. C., Taylor S. L., Dascomb H. E., Greenberg H. B., Ziskind M. M. Disturbed hepatic function during isoniazid chemoprophylaxis. Monitoring the hepatic function of 427 hospital employees receiving isoniazid chemoprophylaxis for tuberculosis. Am Rev Respir Dis. 1973 Apr;107(4):523–529. doi: 10.1164/arrd.1973.107.4.523. [DOI] [PubMed] [Google Scholar]
  3. Byrd C. B., Nelson R., Elliott R. C. Isoniazid toxicity. A prospective study in secondary chemoprophylaxis. JAMA. 1972 Jun 12;220(11):1471–1473. doi: 10.1001/jama.220.11.1471. [DOI] [PubMed] [Google Scholar]
  4. COHEN R., KALSER M. H., THOMSON R. V. Fatal hepatic necrosis secondary to isoniazid therapy. JAMA. 1961 Jun 10;176:877–879. doi: 10.1001/jama.1961.63040230013013b. [DOI] [PubMed] [Google Scholar]
  5. Goldman A. L., Braman S. S. Isoniazid: a review with emphasis on adverse effects. Chest. 1972 Jul;62(1):71–77. doi: 10.1378/chest.62.1.71. [DOI] [PubMed] [Google Scholar]
  6. Grossman L. A., Kaplan H. J., Brittingham T. E. Jaundice and death from isoniazid. J Tenn Med Assoc. 1970 Jan;63(1):23–28. [PubMed] [Google Scholar]
  7. Maddrey W. C., Boitnott J. K. Isoniazid hepatitis. Ann Intern Med. 1973 Jul;79(1):1–12. doi: 10.7326/0003-4819-79-1-1. [DOI] [PubMed] [Google Scholar]
  8. Martin C. E., Arthaud J. B. Hepatitis after isoniazid administration. N Engl J Med. 1970 Feb 19;282(8):433–434. doi: 10.1056/NEJM197002192820808. [DOI] [PubMed] [Google Scholar]
  9. Moss J. D., Lewis J. E., Knauer C. M. Isoniazid-associated hepatitis. A study of five cases. Am Rev Respir Dis. 1972 Dec;106(6):849–856. doi: 10.1164/arrd.1972.106.6.849. [DOI] [PubMed] [Google Scholar]
  10. POPPER H., SCHAFFNER F. Drug-induced hepatic injury. Ann Intern Med. 1959 Dec;51:1230–1252. doi: 10.7326/0003-4819-51-6-1230. [DOI] [PubMed] [Google Scholar]
  11. REITMAN S., FRANKEL S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957 Jul;28(1):56–63. doi: 10.1093/ajcp/28.1.56. [DOI] [PubMed] [Google Scholar]
  12. RUBIN B., HASSERT G. L., Jr, THOMAS B. G. H., BURKE J. C. Pharmacology of isonicotinic acid hydrazide (nydrazid). Am Rev Tuberc. 1952 Apr;65(4):392–401. doi: 10.1164/art.1952.65.4.392. [DOI] [PubMed] [Google Scholar]
  13. Scharer L., Smith J. P. Serum transaminase elevations and other hepatic abnormalities in patients receiving isoniazid. Ann Intern Med. 1969 Dec;71(6):1113–1120. doi: 10.7326/0003-4819-71-6-1113. [DOI] [PubMed] [Google Scholar]
  14. Stead W. W., Texter E. C., Jr Isoniazid hepatitis: backlash of progress. Ann Intern Med. 1973 Jul;79(1):125–127. doi: 10.7326/0003-4819-79-1-125. [DOI] [PubMed] [Google Scholar]

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