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. 1974 Jun;120(6):448–451.

Skeletal Scintigraphy

The Use of Technetium 99M-Labeled Complexes in the Detection of Early Osseous Involvement by Metastatic Tumors

G Bruce Hopkins 1,2, Kai A B Kristensen 1,2, Charles G Campbell 1,2
PMCID: PMC1130175  PMID: 4845922

Abstract

Skeletal scintigraphy using Technetium-99m (99mTc) complexes was carried out in a series of 332 cancer patients. The results of scintigraphy were compared with the results of roentgenography and with the diagnostic usefulness of serum alkaline and acid phosphatase levels and the presence or absence of bone pain. In 25 percent of cases, lesions were first identified with scintigraphs. When metastastic lesions were present on both scintigraphs and roentgenograms, the number was greater on scintigraphs in 72 percent of cases. Six false negative studies were recorded (1 percent). Sixty percent of patients with early metastasis—that is, those with abnormal scintigraphs and negative roentgenograms—were asymptomatic. Serum alkaline and acid phosphatase levels were normal in 40 percent and 42 percent respectively of those with early skeletal involvement. Skeletal scintigraphy with 99mTc complexes is superior to other commonly employed techniques used to assess bone metastasis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell E. G., McAfee J. G., Constable W. C. Local radiation damage to bone and marrow demonstrated by radioisotopic imaging. Radiology. 1969 Apr;92(5):1083–1088. doi: 10.1148/92.5.1083. [DOI] [PubMed] [Google Scholar]
  2. Blau M., Ganatra R., Bender M. A. 18 F-fluoride for bone imaging. Semin Nucl Med. 1972 Jan;2(1):31–37. doi: 10.1016/s0001-2998(72)80005-9. [DOI] [PubMed] [Google Scholar]
  3. Charkes N. D., Young I., Sklaroff D. M. The pathologic basis of the strontium bone scan. Studies following administration of strontium chloride Sr 85 and strontium nitrate Sr 85. JAMA. 1968 Dec 9;206(11):2482–2488. [PubMed] [Google Scholar]
  4. DeNardo G. L., Jacobson S. J., Raventos A. 85 Sr bone scan in neoplastic disease. Semin Nucl Med. 1972 Jan;2(1):18–30. doi: 10.1016/s0001-2998(72)80004-7. [DOI] [PubMed] [Google Scholar]
  5. Galasko C. S. The detection of skeletal metastases from carcinoma of the breast. Surg Gynecol Obstet. 1971 Jun;132(6):1019–1024. [PubMed] [Google Scholar]
  6. Gnekow W. C., DeNardo G. L., Poole G. J., Kriss J. P. Review of a 5-year experience with the radiostrontium bone scintiscan. Calif Med. 1972 Jul;117(1):1–7. [PMC free article] [PubMed] [Google Scholar]
  7. Harbert J. C., Ashburn W. L. Radiostrontium bone scanning in Hodgkin's disease. Cancer. 1968 Jul;22(1):58–63. doi: 10.1002/1097-0142(196807)22:1<58::aid-cncr2820220109>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  8. Hopkins G. B., Kristensen K. A., Blickenstaff D. E. Fluorine 18 bone scans in the detection of early metastatic bone tumors. JAMA. 1972 Nov 13;222(7):813–814. [PubMed] [Google Scholar]
  9. Rubin P., Ciccio S. Status of bone scanning for bone metastases in breast cancer. Cancer. 1969 Dec;24(6):1338–1344. doi: 10.1002/1097-0142(196912)24:6<1338::aid-cncr2820240649>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  10. Subramanian G., McAfee J. G., Bell E. G., Blair R. J., O'Mara R. E., Ralston P. H. 99m Tc-labeled polyphosphate as a skeletal imaging agent. Radiology. 1972 Mar;102(3):701–704. doi: 10.1148/102.3.701. [DOI] [PubMed] [Google Scholar]
  11. Weber W. G., DeNardo G. L., Bergin J. J. Scintiscanning in malignant lymphomatous involvement of bone. Arch Intern Med. 1968 May;121(5):433–437. [PubMed] [Google Scholar]
  12. Yano Y., McRae J., Van Dyke D. C., Anger H. O. Technetium-99m-labeled stannous ethane-1-hydroxy-1 1-diphosphonate: a new bone scanning agent. J Nucl Med. 1973 Feb;14(2):73–78. [PubMed] [Google Scholar]

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